HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Duval, A Articles by Léoty, C Search for Related Content PubMed PubMed Citation Articles by Duval, A Articles by Léoty, C

1. A comparison of the delayed outward current of isolated fibres from rat soleus and iliacus muscle has been made using a double sucrose-gap voltage-clamp method. 2. The fast and slow components of the outward current were separated using time constants of the tail currents. The results indicate that in both iliacus and soleus fibres there is a shift in reversal potential which depends on the quantity of current that flows during depolarization. 3. The shift is larger in iliacus than in soleus; it is absent in glycerol-treated muscles. 4. The results obtained in normal and in detubulated fibres show that the shift is due to an accumulation process of potassium ions in the lumen of the T-tubules. 5. In detubulated soleus fibres the outward current is composed of a fast and a slow component, each with the same reversal potential; in detubulated iliacus the slow component is absent. 6. In both types of muscles TEA produces a dose-dependent block of the total outward current. 4-aminopyridine has different effects; it inhibits the total outward current in iliacus fibres and only the fast component in soleus fibres. 7. These results show that in soleus fibres a fast and a slow component participate in the potassium outward current, while only a fast component is present in iliacus muscle.

This article has been cited by other articles:

				E. Zebedin, W. Sandtner, S. Galler, J. Szendroedi, H. Just, H. Todt, and K. Hilber Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells Am J Physiol Cell Physiol, August 1, 2004; 287(2): C270 - C280. [Abstract] [Full Text] [PDF]