HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Howe, A Articles by Wise, J C Search for Related Content PubMed PubMed Citation Articles by Howe, A Articles by Wise, J C

1. Centripetal activity in fibres in the ventral abdominal vagus nerve of the rat has been studied by recording from fine strands of the divided nerve within the abdomen. 2. In the starved animal, few spontaneously active fibres were located. A proportion of these, however, showed changes in activity in response to changes in F1 oxygen which were typical of arterial chemoreceptor afferent nerves. The resting discharge in these preparations was 0.8-8.0 impulses/sec. In response to extreme hypoxic hypoxia, histotoxic hypoxia or acetylcholine, this discharge increased markedly, with a maximum mean activity of up to 25 impulses/sec. 3. Both the mean/S.D. ratio and statistical comparison with a 'noise' equation were used to assess the apparent random nature of the spike intervals. The former indicated that the spike intervals were random but the latter test was inconclusive. 4. We suggest that this chemoreceptor-like activity originates from the abdominal vagal paraganglia and that these structures may be part of a more generally distributed chemoreceptor system.

This article has been cited by other articles:

				D. D. Kline, Y.-J. Peng, D. J. Manalo, G. L. Semenza, and N. R. Prabhakar Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha PNAS, January 22, 2002; 99(2): 821 - 826. [Abstract] [Full Text] [PDF]