J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 330 pp 111-123
Copyright © 1982 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eckel, L
Right arrow Articles by Satter, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eckel, L
Right arrow Articles by Satter, P

Inotropic and electrophysiological effects of histamine on human ventricular heart muscle.

 L Eckel, R W Gristwood, H Nawrath, D A Owen and P Satter

1. The effects of histamine were investigated on mechanical and electrophysiological parameters in isolated electrically driven human ventricular papillary muscles. The effects of cimetidine and propranolol on histamine responses were also investigated. 2. The effects of histamine were compared with those of noradrenaline, isoprenaline, dimaprit, a selective H2-receptor agonist, and a cyclic AMP derivative, 8-(4-chlorphenylthio) cyclic AMP. 3. The effects of histamine and dimaprit and the effects of cimetidine on histamine responses were also investigated in guinea-pig right ventricular papillary muscles in order to allow a comparison with human papillary muscles. 4. In human papillary muscles, histamine caused concentration-dependent increases in the force of contraction and reductions in both time-to-peak tension and time-to-half-maximal relaxation. Histamine simultaneously caused distinct changes in the action potential configuration with increases in the height and duration of the plateau phase and an increase in the over-all action potential duration. 5. Noradrenaline and isoprenaline produced similar responses to histamine, as did 8-(4-chlorphenylthio) cyclic AMP, consistent with the view that the effects of histamine as well as the beta-adrenoceptor agonists on human ventricle, were associated with cyclic AMP mediated increases in calcium-dependent slow inward current.




This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
G. S. Francis and W.H. W. Tang
Histamine, Mast Cells, and Heart Failure: Is There a Connection?
J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1385 - 1386.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Kim, A. Ogai, S. Nakatani, K. Hashimura, H. Kanzaki, K. Komamura, M. Asakura, H. Asanuma, S. Kitamura, H. Tomoike, et al.
Impact of Blockade of Histamine H2 Receptors on Chronic Heart Failure Revealed by Retrospective and Prospective Randomized Studies
J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1378 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. A. Mulieri, M. D. Tischler, B. J. Martin, B. J. Leavitt, F. P. Ittleman, N. R. Alpert, and M. M. LeWinter
Regional differences in the force-frequency relation of human left ventricular myocardium in mitral regurgitation: implications for ventricular shape
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2185 - H2191.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Matsuda, S. Jesmin, Y. Takahashi, E. Hatta, M. Kobayashi, K. Matsuyama, N. Kawakami, I. Sakuma, S. Gando, H. Fukui, et al.
Histamine H1 and H2 Receptor Gene and Protein Levels Are Differentially Expressed in the Hearts of Rodents and Humans
J. Pharmacol. Exp. Ther., May 1, 2004; 309(2): 786 - 795.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. R. Alpert, L. A. Mulieri, and D. Warshaw
The failing human heart
Cardiovasc Res, April 1, 2002; 54(1): 1 - 10.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 The Physiological Society.