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The changes in the pattern of innervation of extensor digitorum longus (e.d.l.) during post-natal development was studied in normal and dystrophic mice. As in other mammals, individual muscle fibres of new-born mice are supplied by more than one axon. Up to 10 days after birth there was no difference in the extent of this polyneuronal innervation between normal and dystrophic muscle fibres. During post-natal development the polyneuronal innervation gradually disappeared. In normal e.d.l. muscles the rate of the elimination of polyneuronal innervation was faster during the first 10 post-natal days and then slowed down. By 16 days the final value of less than 10% of muscle fibres receiving more than one input was reached. In the dystrophic muscles the rate of elimination was similar to normal up to 10 days of age, but continued to decrease rapidly so that already by 11 days of age polyneuronal innervation was reduced to its final level of less than 10%. Thus the elimination of polyneuronal innervation was completed at least 3 days earlier in the dystrophic animals. It is suggested that the increased nerve activity said to be present in dystrophic mice could account for this finding.