J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 343 pp 439-446
Copyright © 1983 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lumbers, E R
Right arrow Articles by Stevens, A D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lumbers, E R
Right arrow Articles by Stevens, A D

Changes in fetal renal function in response to infusions of a hyperosmotic solution of mannitol to the ewe.

 E R Lumbers and A D Stevens

In six pregnant ewes a reduction in transplacental water transfer was produced by increasing maternal osmolality (by infusion of 180 g of mannitol in 500 ml of 0.15 M-sodium chloride) and the fetal renal responses to this reduction in water transfer were studied. These responses were compared with the renal responses of five other chronically catheterized fetal lambs whose mothers received I.V. infusions of 500 ml of 0.15 M-sodium chloride. Intravenous infusion of 500 ml of 0.15 M-sodium chloride to the ewe produced no changes in fetal plasma sodium, potassium or plasma renin activity and had no effect on fetal renal function. After I.V. infusion of mannitol to the ewe, fetal urinary flow rate fell from control levels of 0.69 +/- 0.12 ml/min to 0.32 +/- 0.04 ml/min (S.E. of mean, P less than 0.006). This fall in urinary flow rate was due to increased water reabsorption because there was no change in glomerular filtration rate and osmolar clearance. Fetal urinary sodium excretion increased from 16.2 +/- 2.0 mumol/min, to 34.2 +/- 6.9 mumol/min (S.E. of mean, P less than 0.04). This increase in fetal urinary sodium excretion was due to a fall in the fractional reabsorption of sodium which was related to this rise in fetal plasma sodium levels that occurred following infusion of mannitol to the ewe. The increases in fetal plasma sodium levels were also associated with reductions in fetal plasma renin activity.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. J. Turner, R. D. Brown, M. Carlstrom, K. J. Gibson, and A. E. G. Persson
Mechanisms of neonatal increase in glomerular filtration rate
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R916 - R921.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. P. Wang and M. J. Paech
Neuroanesthesia for the Pregnant Woman
Anesth. Analg., July 1, 2008; 107(1): 193 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. C. Boyce, K. J. Gibson, C. L. Thomson, and E. R. Lumbers
Interactions between maternal subtotal nephrectomy and salt: effects on renal function and the composition of plasma in the late gestation sheep fetus
Exp Physiol, February 1, 2008; 93(2): 262 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. J. Gibson, A. C. Boyce, B. M. Karime, and E. R. Lumbers
Maternal renal insufficiency alters plasma composition and renal function in the fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1204 - R1211.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. J. Gibson, C. L. Thomson, A. C. Boyce, B. M. Karime, and E. R. Lumbers
Effects of a reduction in maternal renal mass on pregnancy and cardiovascular and renal function of the pregnant ewe
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1153 - F1162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. R. Lumbers, A. C. Boyce, G. Joulianos, V. Kumarasamy, E. Barner, J. L. Segar, and J. H. Burrell
Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R567 - R574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. R. Lumbers, Z.-Y. Yu, and E. N. Crawford
Effects of fetal behavioral states on renal sympathetic nerve activity and arterial pressure of unanesthetized fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R908 - R916.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Marsh, K. J. Gibson, J. Wu, P. C. Owens, J. A. Owens, and E. R. Lumbers
Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R318 - R326.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. R. Lumbers, C. Bernasconi, and J. H. Burrell
Effects of infusions of ACTH in the chronically catheterized pregnant ewe and her fetus
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R445 - R452.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
D. Chelmow, E. R. Baker, and L. Jones
Maternal Intravenous Hydration and Amniotic Fluid Index in Patients With Preterm Ruptured Membranes
Reproductive Sciences, May 1, 1996; 3(3): 127 - 130.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
A. C. Marsh, E. R. Lumbers, and K. J. Gibson
Renal, cardiovascular and endocrine responses of fetal sheep at 0.8 of gestation to an infusion of amino acids
J. Physiol., April 15, 2002; 540(2): 717 - 728.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 The Physiological Society.