| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The electroresponsive properties of guinea-pig thalamic neurones were studied using an in vitro slice preparation. A total of 650 cells were recorded intracellularly comprising all regions of the thalamus; of these 229 fulfilled our criterion for recording stability and were used as the data base for this report. The resting membrane potential for thirty-four representative neurones which were analysed in detail was -64 +/- 5 mV (mean +/- S.D.), input resistance 42 +/- 18 M omega, and action potential amplitude 80 +/- 7 mV. Intracellular staining with horseradish peroxidase and Lucifer Yellow revealed that the recorded cells had different morphology. In some their axonal trajectory characterized them as thalamo-cortical relay cells. Two main types of neuronal firing were observed. From a membrane potential negative to -60 mV, anti- or orthodromic and direct activation generated a single burst of spikes, consisting of a low-threshold spike (l.t.s.) of low amplitude and a set of fast superimposed spikes. Tonic repetitive firing was observed if the neurones were activated from a more positive membrane potential; this was a constant finding in all but two of the cells which fulfilled the stability criteria. The l.t.s. response was totally inactivated at membrane potentials positive to -55 mV. As the membrane was hyperpolarized from this level the amplitude of the l.t.s. increased and became fully developed at potentials negative to -70 mV. This increase is due to a de-inactivation of the ionic conductance generating this response. After activation the l.t.s. showed refractoriness for approximately 170 ms. Deinactivation of l.t.s. is a voltage- and time-dependent process; full de-inactivation after a step hyperpolarization to maximal l.t.s. amplitude (-75 to -80 mV) requires 150-180 ms. Membrane depolarization positive to -55 mV generated sudden sustained depolarizing 'plateau potentials', capable of supporting repetitive firing (each action potential being followed by a marked after-hyperpolarization, a.h.p.). The a.h.p. and the plateau potential controlled the voltage trajectory during the interspike interval and, with the fast spike, constitute a functional state where the thalamic neurone displayed oscillatory properties. Frequency-current (f-I) plots from different initial levels of membrane potential were obtained by the application of square current pulses of long duration (2s). From resting membrane potential and from hyperpolarized levels a rather stereotyped onset firing rate was observed due to the presence of the l.t.s.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  T. Bessaih, N. Leresche, and R. C. Lambert T current potentiation increases the occurrence and temporal fidelity of synaptically evoked burst firing in sensory thalamic neurons PNAS, August 12, 2008; 105(32): 11376 - 11381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Plailly, J. D. Howard, D. R. Gitelman, and J. A. Gottfried Attention to Odor Modulates Thalamocortical Connectivity in the Human Brain J. Neurosci., May 14, 2008; 28(20): 5257 - 5267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Bodor, K. Giber, Z. Rovo, I. Ulbert, and L. Acsady Structural Correlates of Efficient GABAergic Transmission in the Basal Ganglia-Thalamus Pathway J. Neurosci., March 19, 2008; 28(12): 3090 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Guo, J. E. Rubin, C. C. McIntyre, J. L. Vitek, and D. Terman Thalamocortical Relay Fidelity Varies Across Subthalamic Nucleus Deep Brain Stimulation Protocols in a Data-Driven Computational Model J Neurophysiol, March 1, 2008; 99(3): 1477 - 1492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Jia, M. Yue, D. Chandra, A. Keramidas, P. A. Goldstein, G. E. Homanics, and N. L. Harrison Taurine Is a Potent Activator of Extrasynaptic GABAA Receptors in the Thalamus J. Neurosci., January 2, 2008; 28(1): 106 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Landisman and B. W. Connors VPM and PoM Nuclei of the Rat Somatosensory Thalamus: Intrinsic Neuronal Properties and Corticothalamic Feedback Cereb Cortex, December 1, 2007; 17(12): 2853 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Jones Calcium channels in higher-level brain function PNAS, November 13, 2007; 104(46): 17903 - 17904. [Full Text] [PDF]
|
|
|
|
|
|
U. Kim and L.-y. Chung Dual GABAergic Synaptic Response of Fast Excitation and Slow Inhibition in the Medial Habenula of Rat Epithalamus J Neurophysiol, September 1, 2007; 98(3): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Weyand Retinogeniculate Transmission in Wakefulness J Neurophysiol, August 1, 2007; 98(2): 769 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Lee, G. Govindaiah, and C. L. Cox Heterogeneity of firing properties among rat thalamic reticular nucleus neurons J. Physiol., July 1, 2007; 582(1): 195 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Augustinaite and P. Heggelund Changes in firing pattern of lateral geniculate neurons caused by membrane potential dependent modulation of retinal input through NMDA receptors J. Physiol., July 1, 2007; 582(1): 297 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Labra, C. Rivadulla, K. Grieve, J. Marino, N. Espinosa, and J. Cudeiro Changes in Visual Responses in the Feline dLGN: Selective Thalamic Suppression Induced by Transcranial Magnetic Stimulation of V1 Cereb Cortex, June 1, 2007; 17(6): 1376 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Margolis and P. B. Detwiler Different Mechanisms Generate Maintained Activity in ON and OFF Retinal Ganglion Cells J. Neurosci., May 30, 2007; 27(22): 5994 - 6005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Balu and B. W. Strowbridge Opposing Inward and Outward Conductances Regulate Rebound Discharges in Olfactory Mitral Cells J Neurophysiol, March 1, 2007; 97(3): 1959 - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Perreault and M. Raastad Contribution of morphology and membrane resistance to integration of fast synaptic signals in two thalamic cell types J. Physiol., November 15, 2006; 577(1): 205 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Iremonger, T. R. Anderson, B. Hu, and Z. H. T. Kiss Cellular Mechanisms Preventing Sustained Activation of Cortex During Subcortical High-Frequency Stimulation J Neurophysiol, August 1, 2006; 96(2): 613 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Lee and C. L. Cox Excitatory Actions of Vasoactive Intestinal Peptide on Mouse Thalamocortical Neurons Are Mediated by VPAC2 Receptors J Neurophysiol, August 1, 2006; 96(2): 858 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Frohlich, M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability. J. Neurosci., June 7, 2006; 26(23): 6153 - 6162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Hains, C. Y. Saab, and S. G. Waxman Alterations in Burst Firing of Thalamic VPL Neurons and Reversal by Nav1.3 Antisense After Spinal Cord Injury J Neurophysiol, June 1, 2006; 95(6): 3343 - 3352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Llinas and M. Steriade Bursting of Thalamic Neurons and States of Vigilance J Neurophysiol, June 1, 2006; 95(6): 3297 - 3308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McAlonan, J. Cavanaugh, and R. H. Wurtz Attentional modulation of thalamic reticular neurons. J. Neurosci., April 19, 2006; 26(16): 4444 - 4450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Molineux, J. E. McRory, B. E. McKay, J. Hamid, W. H. Mehaffey, R. Rehak, T. P. Snutch, G. W. Zamponi, and R. W. Turner Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons PNAS, April 4, 2006; 103(14): 5555 - 5560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Uebachs, C. Schaub, E. Perez-Reyes, and H. Beck T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates J. Physiol., March 15, 2006; 571(3): 519 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Anderson, B. Hu, K. Iremonger, and Z. H. T. Kiss Selective Attenuation of Afferent Synaptic Transmission as a Mechanism of Thalamic Deep Brain Stimulation-Induced Tremor Arrest J. Neurosci., January 18, 2006; 26(3): 841 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Kass and I. M. Mintz Silent plateau potentials, rhythmic bursts, and pacemaker firing: Three patterns of activity that coexist in quadristable subthalamic neurons PNAS, January 3, 2006; 103(1): 183 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Lee, S. Ohara, P. M. Dougherty, and F. A. Lenz Pain and Temperature Encoding in the Human Thalamic Somatic Sensory Nucleus (Ventral caudal): Inhibition-Related Bursting Evoked by Somatic Stimuli J Neurophysiol, September 1, 2005; 94(3): 1676 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Ramcharan, J. W. Gnadt, and S. M. Sherman Higher-order thalamic relays burst more than first-order relays PNAS, August 23, 2005; 102(34): 12236 - 12241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A Rhodes and R. Llinas A model of thalamocortical relay cells J. Physiol., June 15, 2005; 565(3): 765 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Grubb and I. D. Thompson Visual Response Properties of Burst and Tonic Firing in the Mouse Dorsal Lateral Geniculate Nucleus J Neurophysiol, June 1, 2005; 93(6): 3224 - 3247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Broberger and D. A. McCormick Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus J. Neurosci., February 16, 2005; 25(7): 1664 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Alitto, T. G. Weyand, and W. M. Usrey Distinct Properties of Stimulus-Evoked Bursts in the Lateral Geniculate Nucleus J. Neurosci., January 12, 2005; 25(2): 514 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee, D. Kim, and H.-S. Shin Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking {alpha}1G-subunit of T-type calcium channels PNAS, December 28, 2004; 101(52): 18195 - 18199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Saito and T. Isa Laminar Specific Distribution of Lateral Excitatory Connections in the Rat Superior Colliculus J Neurophysiol, December 1, 2004; 92(6): 3500 - 3510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. I. Dzhala and K. J. Staley Mechanisms of Fast Ripples in the Hippocampus J. Neurosci., October 6, 2004; 24(40): 8896 - 8906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Q. Yu, Y. Xiong, Y.-S. Chan, and J. He In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs J. Physiol., October 1, 2004; 560(1): 191 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Grubb and I. D. Thompson Visual Response Properties in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the {beta}2 Subunit of the Nicotinic Acetylcholine Receptor J. Neurosci., September 29, 2004; 24(39): 8459 - 8469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Anderson, B. Hu, Q. Pittman, and Z. H. T. Kiss Mechanisms of deep brain stimulation: an intracellular study in rat thalamus J. Physiol., August 15, 2004; 559(1): 301 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Leresche, J. Hering, and R. C. Lambert Paradoxical Potentiation of Neuronal T-Type Ca2+ Current by ATP at Resting Membrane Potential J. Neurosci., June 16, 2004; 24(24): 5592 - 5602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Massaux, G. Dutrieux, N. Cotillon-Williams, Y. Manunta, and J.-M. Edeline Auditory Thalamus Bursts in Anesthetized and Non-Anesthetized States: Contribution to Functional Properties J Neurophysiol, May 1, 2004; 91(5): 2117 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Womack and K. Khodakhah Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells J. Neurosci., April 7, 2004; 24(14): 3511 - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. McIntyre, W. M. Grill, D. L. Sherman, and N. V. Thakor Cellular Effects of Deep Brain Stimulation: Model-Based Analysis of Activation and Inhibition J Neurophysiol, April 1, 2004; 91(4): 1457 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-y. Chang and U. Kim Ionic Mechanism of Long-Lasting Discharges of Action Potentials Triggered by Membrane Hyperpolarization in the Medial Lateral Habenula J. Neurosci., March 3, 2004; 24(9): 2172 - 2181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Mooney, L. Zhang, C. Basile, V. V. Senatorov, J. Ngsee, A. Omar, and B. Hu Distinct forms of cholinergic modulation in parallel thalamic sensory pathways PNAS, January 6, 2004; 101(1): 320 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Pinato and J. Midtgaard Regulation of Granule Cell Excitability by a Low-Threshold Calcium Spike in Turtle Olfactory Bulb J Neurophysiol, November 1, 2003; 90(5): 3341 - 3351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kim, D. Park, S. Choi, S. Lee, M. Sun, C. Kim, and H.-S. Shin Thalamic Control of Visceral Nociception Mediated by T-Type Ca2+ Channels Science, October 3, 2003; 302(5642): 117 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Blitz and W. G. Regehr Retinogeniculate Synaptic Properties Controlling Spike Number and Timing in Relay Neurons J Neurophysiol, October 1, 2003; 90(4): 2438 - 2450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. DESTEXHE and T. J. SEJNOWSKI Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations Physiol Rev, October 1, 2003; 83(4): 1401 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mu, W. B. Carden, N. C. Kurukulasuriya, G. M. Alexander, and D. W. Godwin Ethanol Influences on Native T-Type Calcium Current in Thalamic Sleep Circuitry J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 197 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Lee and C. L. Cox Vasoactive Intestinal Peptide Selectively Depolarizes Thalamic Relay Neurons and Attenuates Intrathalamic Rhythmic Activity J Neurophysiol, August 1, 2003; 90(2): 1224 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Staba, B. Brett-Green, M. Paulsen, and D. S. Barth Effects of Ventrobasal Lesion and Cortical Cooling on Fast Oscillations (>200 Hz) in Rat Somatosensory Cortex J Neurophysiol, May 1, 2003; 89(5): 2380 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-X. Shi and X.-X. Zhang Dendritic Glutamate-Induced Bursting in the Prefrontal Cortex: Further Characterization and Effects of Phencyclidine J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 680 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Temereanca and D. J. Simons Local Field Potentials and the Encoding of Whisker Deflections by Population Firing Synchrony in Thalamic Barreloids J Neurophysiol, April 1, 2003; 89(4): 2137 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-Q. Sun, D. A. Prince, and J. R. Huguenard Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide Activate Hyperpolarization-Activated Cationic Current and Depolarize Thalamocortical Neurons In Vitro J. Neurosci., April 1, 2003; 23(7): 2751 - 2758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Lee, J. J. Kuo, M. C. Jiang, and C. J. Heckman Influence of Active Dendritic Currents on Input-Output Processing in Spinal Motoneurons In Vivo J Neurophysiol, January 1, 2003; 89(1): 27 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Porcello, S. D. Smith, and J. R. Huguenard Actions of U-92032, a T-Type Ca2+ Channel Antagonist, Support a Functional Linkage Between IT and Slow Intrathalamic Rhythms J Neurophysiol, January 1, 2003; 89(1): 177 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Smith and S. M. Sherman Detectability of Excitatory versus Inhibitory Drive in an Integrate-and-Fire-or-Burst Thalamocortical Relay Neuron Model J. Neurosci., December 1, 2002; 22(23): 10242 - 10250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kepecs, X.-J. Wang, and J. Lisman Bursting Neurons Signal Input Slope J. Neurosci., October 15, 2002; 22(20): 9053 - 9062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borisyuk, M. N. Semple, and J. Rinzel Adaptation and Inhibition Underlie Responses to Time-Varying Interaural Phase Cues in a Model of Inferior Colliculus Neurons J Neurophysiol, October 1, 2002; 88(4): 2134 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Crabtree and J. T. R. Isaac New Intrathalamic Pathways Allowing Modality-Related and Cross-Modality Switching in the Dorsal Thalamus J. Neurosci., October 1, 2002; 22(19): 8754 - 8761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bayer, E. Eggermann, B. Saint-Mleux, D. Machard, B. E. Jones, M. Muhlethaler, and M. Serafin Selective Action of Orexin (Hypocretin) on Nonspecific Thalamocortical Projection Neurons J. Neurosci., September 15, 2002; 22(18): 7835 - 7839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Monckton and D. A. McCormick Neuromodulatory Role of Serotonin in the Ferret Thalamus J Neurophysiol, April 1, 2002; 87(4): 2124 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-S. Lo, J. Ziburkus, and W. Guido Synaptic Mechanisms Regulating the Activation of a Ca2+-Mediated Plateau Potential in Developing Relay Cells of the LGN J Neurophysiol, March 1, 2002; 87(3): 1175 - 1185. |
