J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 349 pp 419-440
Copyright © 1984 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diamond, J M
Right arrow Articles by Yung, R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diamond, J M
Right arrow Articles by Yung, R

Effect of dietary carbohydrate on monosaccharide uptake by mouse small intestine in vitro.

 J M Diamond, W H Karasov, C Cary, D Enders and R Yung

Using intestinal sleeves in vitro, we studied the effect of dietary carbohydrate on active monosaccharide uptake in mice. Dietary carbohydrate did not affect numerous parameters of intestinal structure, such as length, circumference, weight, protein content, villus dimensions and density, and area at the villus level. Mice on a carbohydrate-free diet had active D-glucose uptake relatively independent of position along the small intestine. A carbohydrate-containing diet reversibly and within 1 day stimulated uptake except in the ileum, restoring the proximal-to-distal gradient in glucose uptake normally observed. This stimulation involved a 81-116% increase in the Michaelis- Menton constant Vmax, and also an apparent increase in the Michaelis- Menton constant Km, that may however be an artifact arising from unstirred-layer effects. Active uptake of 3-O-methyl-D-glucose also increased, permeability to glucose remained unchanged, and proline uptake reversibly decreased (probably due to the lower protein content of the carbohydrate-containing diets). The effect of fasting on active monosaccharide uptake seemed largely due to withdrawal of dietary carbohydrate, rather than of calories per se. It is concluded that dietary carbohydrate causes induction of monosaccharide carriers in the intestine, along with its more familiar induction of pancreatic amylase and intestinal disaccharidases. Substrate-dependent carrier induction may be physiologically significant in maintaining the proximal-to-distal gradient of glucose transport. An appendix presents measurements of villus area as a function of position along the intestine.




This article has been cited by other articles:


Home page
 Poult. Sci.Home page
O. T. Foye, P. R. Ferket, and Z. Uni
The Effects of In Ovo Feeding Arginine, {beta}-Hydroxy-{beta}-Methyl-Butyrate, and Protein on Jejunal Digestive and Absorptive Activity in Embryonic and Neonatal Turkey Poults
Poult. Sci., November 1, 2007; 86(11): 2343 - 2349.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
L. A. Drozdowski, M. Suh, E. Park, M. T. Clandinin, and A. B. R. Thomson
Dietary Gangliosides Enhance In Vitro Glucose Uptake in Weanling Rats
JPEN J Parenter Enteral Nutr, September 1, 2007; 31(5): 423 - 429.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. M. Kristan and K. A. Hammond
Morphological plasticity varies with duration of infection: evidence from lactating and virgin wild-derived house mice (Mus musculus) infected with an intestinal parasite (Heligmosomoides polygyrus; Nematoda)
J. Exp. Biol., June 1, 2004; 207(13): 2351 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
Y. Kimura, K. K. Buddington, and R. K. Buddington
The Influence of Estradiol and Diet on Small Intestinal Glucose Transport in Ovariectomized Rats
Experimental Biology and Medicine, March 1, 2004; 229(3): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. M. Kristan
Effects of intestinal nematodes during lactation: consequences for host morphology, physiology and offspring mass
J. Exp. Biol., December 15, 2002; 205(24): 3955 - 3965.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. M. Kristan
Maternal and direct effects of the intestinal nematode Heligmosomoides polygyrus on offspring growth and susceptibility to infection
J. Exp. Biol., December 15, 2002; 205(24): 3967 - 3977.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Barfull, C. Garriga, A. Tauler, and J. M. Planas
Regulation of SGLT1 expression in response to Na+ intake
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R738 - R743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. M. Kristan and K. A. Hammond
Parasite infection and caloric restriction induce physiological and morphological plasticity
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R502 - R510.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. P. Ferraris, Q.-X. Cao, and S. Prabhakaram
Chronic but Not Acute Energy Restriction Increases Intestinal Nutrient Transport in Mice
J. Nutr., March 1, 2001; 131(3): 779 - 786.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. P. O'Connor, M. M. Lam, and J. Diamond
Magnitude of functional adaptation after intestinal resection
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1265 - R1275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
E. Weber and H. J Ehrlein
Composition of enteral diets and meals providing optimal absorption rates of nutrients in mini pigs
Am. J. Clinical Nutrition, March 1, 1999; 69(3): 556 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. P. O'Connor and J. Diamond
Ontogeny of intestinal safety factors: lactase capacities and lactose loads
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R753 - R765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Livesey, P. D. G. Wilson, M. A. Roe, R. M. Faulks, L. M. Oram, J. C. Brown, J. Eagles, R. H. Greenwood, and H. Kennedy
Splanchnic retention of intraduodenal and intrajejunal glucose in healthy adults
Am J Physiol Endocrinol Metab, October 1, 1998; 275(4): E709 - E716.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Weber and H. J. Ehrlein
Reserve capacities of the small intestine for absorption of energy
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R300 - R307.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. A. Lee, S. L. Weiss, M. Lam, R. Torres, and J. Diamond
A method for assaying intestinal brush-border sucrase in an intact intestinal preparation
PNAS, March 3, 1998; 95(5): 2111 - 2116.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. L. Weiss, E. A. Lee, and J. Diamond
Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border
PNAS, March 3, 1998; 95(5): 2117 - 2121.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Torras-Llort, J. F. Soriano-Garcia, R. Ferrer, and M. Moreto
Effect of a lysine-enriched diet on L-lysine transport by the brush-border membrane of the chicken jejunum
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R69 - R75.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 The Physiological Society.