HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Madison, D V Articles by Nicoll, R A Search for Related Content PubMed PubMed Citation Articles by Madison, D V Articles by Nicoll, R A

Experiments using intracellular recording techniques were performed on rat hippocampal neurones in vitro, to study the discharge properties of these cells. When CA 1 pyramidal cells were excited by injecting long depolarizing current pulses (approximately 600-800 ms), they responded with an initial rapid action potential discharge which slowed, or accommodated, and then stopped after 200-300 ms. The train of action potentials was followed by a hyperpolarization which was due primarily to calcium-activated potassium conductance (GK(Ca]. The amplitude of this hyperpolarization increased with an increasing number of action potentials in the initial discharge. Blocking the calcium-activated potassium conductance, by injecting EGTA into the cell, by bathing the cell in cadmium, a calcium channel blocker, or by bathing the cell in calcium-free medium, reduced the after-hyperpolarization (a.h.p.) and accommodation such that the frequency of action potential discharge increased and the duration of this discharge was prolonged. Blocking the calcium-activated potassium conductance had a greater effect on discharge frequency later in the action potential train, as late interspike intervals were shortened more than early ones by the application of cadmium or of calcium-free medium. This was presumably because the calcium-activated potassium conductance was more developed later in the train. Accommodation was not completely abolished in the absence of calcium and presence of cadmium, suggesting that other factors, in addition to calcium-activated potassium conductance, contributed to this process. This remaining accommodation was reduced by low doses of carbachol, suggesting that the M-current also plays a role in accommodation. We conclude that accommodation of the action potential discharge of hippocampal pyramidal cells may be regulated by at least two potassium currents: the calcium-activated potassium current and the M-current. Both of these currents are turned on during excitation of the neurone and act in an inhibitory manner on that neurone to limit further action potential discharge.

This article has been cited by other articles:

				G. C. Lowe, G. N. Luheshi, and S. Williams Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1563 - R1571. [Abstract] [Full Text] [PDF]

				T. A. Engel, L. Schimansky-Geier, A.V.M. Herz, S. Schreiber, and I. Erchova Subthreshold Membrane-Potential Resonances Shape Spike-Train Patterns in the Entorhinal Cortex J Neurophysiol, September 1, 2008; 100(3): 1576 - 1589. [Abstract] [Full Text] [PDF]

				J. Ambros-Ingerson, L. M. Grover, and W. R. Holmes A Classification Method to Distinguish Cell-Specific Responses Elicited by Current Pulses in Hippocampal CA1 Pyramidal Cells Neural Comput., June 1, 2008; 20(6): 1512 - 1536. [Abstract] [Full Text] [PDF]

				Z. Jia, J. Bei, L. Rodat-Despoix, B. Liu, Q. Jia, P. Delmas, and H. Zhang NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background J. Gen. Physiol., June 1, 2008; 131(6): 575 - 587. [Abstract] [Full Text] [PDF]

				S. Curti, L. Gomez, R. Budelli, and A. E. Pereda Subthreshold Sodium Current Underlies Essential Functional Specializations at Primary Auditory Afferents J Neurophysiol, April 1, 2008; 99(4): 1683 - 1699. [Abstract] [Full Text] [PDF]

				M. Diaz-Quesada and M. Maravall Intrinsic Mechanisms for Adaptive Gain Rescaling in Barrel Cortex J. Neurosci., January 16, 2008; 28(3): 696 - 710. [Abstract] [Full Text] [PDF]

				P. Wallen, B. Robertson, L. Cangiano, P. Low, A. Bhattacharjee, L. K. Kaczmarek, and S. Grillner Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons J. Physiol., November 15, 2007; 585(1): 75 - 90. [Abstract] [Full Text] [PDF]

				S. I. Cohen-Matsliah, I. Brosh, K. Rosenblum, and E. Barkai A Novel Role for Extracellular Signal-Regulated Kinase in Maintaining Long-Term Memory-Relevant Excitability Changes J. Neurosci., November 14, 2007; 27(46): 12584 - 12589. [Abstract] [Full Text] [PDF]

				M. Yoshida and A. Alonso Cell-Type Specific Modulation of Intrinsic Firing Properties and Subthreshold Membrane Oscillations by the M(Kv7)-Current in Neurons of the Entorhinal Cortex J Neurophysiol, November 1, 2007; 98(5): 2779 - 2794. [Abstract] [Full Text] [PDF]

				M. Fuenzalida, D. Fernandez de Sevilla, and W. Buno Changes of the EPSP Waveform Regulate the Temporal Window for Spike-Timing-Dependent Plasticity J. Neurosci., October 31, 2007; 27(44): 11940 - 11948. [Abstract] [Full Text] [PDF]

				R. Yamamoto, Y. Ueta, and N. Kato Dopamine Induces a Slow Afterdepolarization in Lateral Amygdala Neurons J Neurophysiol, August 1, 2007; 98(2): 984 - 992. [Abstract] [Full Text] [PDF]

				D. Fernandez de Sevilla, M. Fuenzalida, A. B. Porto Pazos, and W. Buno Selective Shunting of the NMDA EPSP Component by the Slow Afterhyperpolarization in Rat CA1 Pyramidal Neurons J Neurophysiol, May 1, 2007; 97(5): 3242 - 3255. [Abstract] [Full Text] [PDF]

				N. Gu, K. Vervaeke, and J. F. Storm BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells J. Physiol., May 1, 2007; 580(3): 859 - 882. [Abstract] [Full Text] [PDF]

				C. C. Kaczorowski, J. Disterhoft, and N. Spruston Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions J. Physiol., February 1, 2007; 578(3): 799 - 818. [Abstract] [Full Text] [PDF]

				X. Cai, D.-S. Wei, S. E. Gallagher, A. Bagal, Y.-A. Mei, J. P. Y. Kao, S. M. Thompson, and C.-M. Tang Hyperexcitability of Distal Dendrites in Hippocampal Pyramidal Cells after Chronic Partial Deafferentation J. Neurosci., January 3, 2007; 27(1): 59 - 68. [Abstract] [Full Text] [PDF]

				G. G. Murphy, V. Shah, J. W. Hell, and A. J. Silva Investigation of Age-Related Cognitive Decline Using Mice as a Model System: Neurophysiological Correlates Am J Geriatr Psychiatry, December 1, 2006; 14(12): 1012 - 1021. [Abstract] [Full Text] [PDF]

				D. Golomb, C. Yue, and Y. Yaari Contribution of Persistent Na+ Current and M-Type K+ Current to Somatic Bursting in CA1 Pyramidal Cells: Combined Experimental and Modeling Study J Neurophysiol, October 1, 2006; 96(4): 1912 - 1926. [Abstract] [Full Text] [PDF]

				I. Brosh, K. Rosenblum, and E. Barkai Learning-Induced Reversal of the Effect of Noradrenalin on the Postburst AHP J Neurophysiol, October 1, 2006; 96(4): 1728 - 1733. [Abstract] [Full Text] [PDF]

				K. Vervaeke, N. Gu, C. Agdestein, H. Hu, and J. F. Storm Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release J. Physiol., October 1, 2006; 576(1): 235 - 256. [Abstract] [Full Text] [PDF]

				S. A. Prescott, S. Ratte, Y. De Koninck, and T. J. Sejnowski Nonlinear Interaction between Shunting and Adaptation Controls a Switch between Integration and Coincidence Detection in Pyramidal Neurons J. Neurosci., September 6, 2006; 26(36): 9084 - 9097. [Abstract] [Full Text] [PDF]

				A. K. Filippov, R. C. Y. Choi, J. Simon, E. A. Barnard, and D. A. Brown Activation of P2Y1 Nucleotide Receptors Induces Inhibition of the M-Type K+ Current in Rat Hippocampal Pyramidal Neurons J. Neurosci., September 6, 2006; 26(36): 9340 - 9348. [Abstract] [Full Text] [PDF]

				M. H. Higgs, S. J. Slee, and W. J. Spain Diversity of gain modulation by noise in neocortical neurons: regulation by the slow afterhyperpolarization conductance. J. Neurosci., August 23, 2006; 26(34): 8787 - 8799. [Abstract] [Full Text] [PDF]

				C. Yue and Y. Yaari Axo-Somatic and Apical Dendritic Kv7/M Channels Differentially Regulate the Intrinsic Excitability of Adult Rat CA1 Pyramidal Cells J Neurophysiol, June 1, 2006; 95(6): 3480 - 3495. [Abstract] [Full Text] [PDF]

				I. Zelcer, H. Cohen, G. Richter-Levin, T. Lebiosn, T. Grossberger, and E. Barkai A Cellular Correlate of Learning-induced Metaplasticity in the Hippocampus Cereb Cortex, April 1, 2006; 16(4): 460 - 468. [Abstract] [Full Text] [PDF]

				N. Shin, H. Soh, S. Chang, D. H. Kim, and C.-S. Park Sodium Permeability of a Cloned Small-Conductance Calcium-Activated Potassium Channel Biophys. J., November 1, 2005; 89(5): 3111 - 3119. [Abstract] [Full Text] [PDF]

				S. Chen, C. Yue, and Y. Yaari A transitional period of Ca2+-dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells J. Physiol., August 15, 2005; 567(1): 79 - 93. [Abstract] [Full Text] [PDF]

				N. Gu, K. Vervaeke, H. Hu, and J. F Storm Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells J. Physiol., August 1, 2005; 566(3): 689 - 715. [Abstract] [Full Text] [PDF]

				G. B Miles, Y Dai, and R. M Brownstone Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones J. Physiol., July 15, 2005; 566(2): 519 - 532. [Abstract] [Full Text] [PDF]

				J. C. F. Lee, J. C. Callaway, and R. C. Foehring Effects of Temperature on Calcium Transients and Ca2+-Dependent Afterhyperpolarizations in Neocortical Pyramidal Neurons J Neurophysiol, April 1, 2005; 93(4): 2012 - 2020. [Abstract] [Full Text] [PDF]

				J. Zeng, R. K. Powers, G. Newkirk, M. Yonkers, and M. D. Binder Contribution of Persistent Sodium Currents to Spike-Frequency Adaptation in Rat Hypoglossal Motoneurons J Neurophysiol, February 1, 2005; 93(2): 1035 - 1041. [Abstract] [Full Text] [PDF]

				V. F. Descalzo, L. G. Nowak, J. C. Brumberg, D. A. McCormick, and M. V. Sanchez-Vives Slow Adaptation in Fast-Spiking Neurons of Visual Cortex J Neurophysiol, February 1, 2005; 93(2): 1111 - 1118. [Abstract] [Full Text] [PDF]

				A. Fisahn Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool J. Physiol., January 1, 2005; 562(1): 65 - 72. [Abstract] [Full Text] [PDF]

				A. Fisahn, S. F. Heinemann, and C. J. McBain The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones J. Physiol., January 1, 2005; 562(1): 199 - 203. [Abstract] [Full Text] [PDF]

				W. W. Wu, C. S. Chan, and J. F. Disterhoft Slow Afterhyperpolarization Governs the Development of NMDA Receptor-Dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation J Neurophysiol, October 1, 2004; 92(4): 2346 - 2356. [Abstract] [Full Text] [PDF]

				T. Gollisch and A. V. M. Herz Input-Driven Components of Spike-Frequency Adaptation Can Be Unmasked In Vivo J. Neurosci., August 25, 2004; 24(34): 7435 - 7444. [Abstract] [Full Text] [PDF]

				Z. Melyan, B. Lancaster, and H. V. Wheal Metabotropic Regulation of Intrinsic Excitability by Synaptic Activation of Kainate Receptors J. Neurosci., May 12, 2004; 24(19): 4530 - 4534. [Abstract] [Full Text] [PDF]

				C. Yue and Y. Yaari KCNQ/M Channels Control Spike Afterdepolarization and Burst Generation in Hippocampal Neurons J. Neurosci., May 12, 2004; 24(19): 4614 - 4624. [Abstract] [Full Text] [PDF]

				E. S. L. Faber and P. Sah Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing a Dendritic Potassium Current J. Neurosci., March 24, 2004; 24(12): 3031 - 3039. [Abstract] [Full Text] [PDF]

				J. Maylie, C. T. Bond, P. S. Herson, W.-S. Lee, and J. P. Adelman Small conductance Ca2+-activated K+ channels and calmodulin J. Physiol., January 15, 2004; 554(2): 255 - 261. [Abstract] [Full Text] [PDF]

				J. Benda and A. V. M. Herz A Universal Model for Spike-Frequency Adaptation Neural Comput., November 1, 2003; 15(11): 2523 - 2564. [Abstract] [Full Text] [PDF]

				W.-S. Lee, T. J. Ngo-Anh, A. Bruening-Wright, J. Maylie, and J. P. Adelman Small Conductance Ca2+-activated K+ Channels and Calmodulin: CELL SURFACE EXPRESSION AND GATING J. Biol. Chem., July 3, 2003; 278(28): 25940 - 25946. [Abstract] [Full Text] [PDF]

				S. P. Schneider Spike Frequency Adaptation and Signaling Properties of Identified Neurons in Rodent Deep Spinal Dorsal Horn J Neurophysiol, July 1, 2003; 90(1): 245 - 258. [Abstract] [Full Text] [PDF]

				S. Franceschetti, T. Lavazza, G. Curia, P. Aracri, F. Panzica, G. Sancini, G. Avanzini, and J. Magistretti Na+-Activated K+ Current Contributes to Postexcitatory Hyperpolarization in Neocortical Intrinsically Bursting Neurons J Neurophysiol, April 1, 2003; 89(4): 2101 - 2111. [Abstract] [Full Text] [PDF]

				M. D. Womack and K. Khodakhah Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons J. Neurosci., April 1, 2003; 23(7): 2600 - 2607. [Abstract] [Full Text] [PDF]

				M. J. Chacron, K. Pakdaman, and A. Longtin Interspike Interval Correlations, Memory, Adaptation, and Refractoriness in a Leaky Integrate-and-Fire Model with Threshold Fatigue Neural Comput., February 1, 2003; 15(2): 253 - 278. [Abstract] [Full Text] [PDF]

				P. A. Goldstein, F. P. Elsen, S.-W. Ying, C. Ferguson, G. E. Homanics, and N. L. Harrison Prolongation of Hippocampal Miniature Inhibitory Postsynaptic Currents in Mice Lacking the GABAA Receptor alpha 1 Subunit J Neurophysiol, December 1, 2002; 88(6): 3208 - 3217. [Abstract] [Full Text] [PDF]

				G. Fuhrmann, H. Markram, and M. Tsodyks Spike Frequency Adaptation and Neocortical Rhythms J Neurophysiol, August 1, 2002; 88(2): 761 - 770. [Abstract] [Full Text] [PDF]

				C. Sekirnjak and S. du Lac Intrinsic Firing Dynamics of Vestibular Nucleus Neurons J. Neurosci., March 15, 2002; 22(6): 2083 - 2095. [Abstract] [Full Text] [PDF]

				O. Thibault, R. Hadley, and P. W. Landfield Elevated Postsynaptic [Ca2+]i and L-Type Calcium Channel Activity in Aged Hippocampal Neurons: Relationship to Impaired Synaptic Plasticity J. Neurosci., December 15, 2001; 21(24): 9744 - 9756. [Abstract] [Full Text] [PDF]

				E. D. Martin, A. Araque, and W. Buno Synaptic Regulation of the Slow Ca2+-Activated K+ Current in Hippocampal CA1 Pyramidal Neurons: Implication in Epileptogenesis J Neurophysiol, December 1, 2001; 86(6): 2878 - 2886. [Abstract] [Full Text] [PDF]

				A. Bibbig, H. J. Faulkner, M. A. Whittington, and R. D. Traub Self-Organized Synaptic Plasticity Contributes to the Shaping of gamma and beta Oscillations In Vitro J. Neurosci., November 15, 2001; 21(22): 9053 - 9067. [Abstract] [Full Text] [PDF]

				M. J. Saganich, E. Machado, and B. Rudy Differential Expression of Genes Encoding Subthreshold-Operating Voltage-Gated K+ Channels in Brain J. Neurosci., July 1, 2001; 21(13): 4609 - 4624. [Abstract] [Full Text] [PDF]

				H. Su, G. Alroy, E. D. Kirson, and Y. Yaari Extracellular Calcium Modulates Persistent Sodium Current-Dependent Burst-Firing in Hippocampal Pyramidal Neurons J. Neurosci., June 15, 2001; 21(12): 4173 - 4182. [Abstract] [Full Text] [PDF]

				D. Saar, Y. Grossman, and E. Barkai Long-Lasting Cholinergic Modulation Underlies Rule Learning in Rats J. Neurosci., February 15, 2001; 21(4): 1385 - 1392. [Abstract] [Full Text] [PDF]

				E.S.L. Faber, R. J. Callister, and P. Sah Morphological and Electrophysiological Properties of Principal Neurons in the Rat Lateral Amygdala In Vitro J Neurophysiol, February 1, 2001; 85(2): 714 - 723. [Abstract] [Full Text] [PDF]

				K. Nishikawa and M. B. MacIver Membrane and Synaptic Actions of Halothane on Rat Hippocampal Pyramidal Neurons and Inhibitory Interneurons J. Neurosci., August 15, 2000; 20(16): 5915 - 5923. [Abstract] [Full Text] [PDF]

				J. R. Moyer Jr, J. M. Power, L. T. Thompson, and J. F. Disterhoft Increased Excitability of Aged Rabbit CA1 Neurons after Trace Eyeblink Conditioning J. Neurosci., July 15, 2000; 20(14): 5476 - 5482. [Abstract] [Full Text] [PDF]

				T. Aoki and S. C. Baraban Properties of a Calcium-Activated K+ Current on Interneurons in the Developing Rat Hippocampus J Neurophysiol, June 1, 2000; 83(6): 3453 - 3461. [Abstract] [Full Text] [PDF]

				M. V. Sanchez-Vives, L. G. Nowak, and D. A. McCormick Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro J. Neurosci., June 1, 2000; 20(11): 4286 - 4299. [Abstract] [Full Text] [PDF]

				T. Haug and J. F. Storm Protein Kinase A Mediates the Modulation of the Slow Ca2+-Dependent K+ Current, IsAHP, by the Neuropeptides CRF, VIP, and CGRP in Hippocampal Pyramidal Neurons J Neurophysiol, April 1, 2000; 83(4): 2071 - 2079. [Abstract] [Full Text] [PDF]

				C. Weiss, A. R. Preston, M. M. Oh, R. D. Schwarz, D. Welty, and J. F. Disterhoft The M1 Muscarinic Agonist CI-1017 Facilitates Trace Eyeblink Conditioning in Aging Rabbits and Increases the Excitability of CA1 Pyramidal Neurons J. Neurosci., January 15, 2000; 20(2): 783 - 790. [Abstract] [Full Text] [PDF]

				J. E. Keen, R. Khawaled, D. L. Farrens, T. Neelands, A. Rivard, C. T. Bond, A. Janowsky, B. Fakler, J. P. Adelman, and J. Maylie Domains Responsible for Constitutive and Ca2+-Dependent Interactions between Calmodulin and Small Conductance Ca2+-Activated Potassium Channels J. Neurosci., October 15, 1999; 19(20): 8830 - 8838. [Abstract] [Full Text] [PDF]

A. Araque and W. Buno Fast BK-