J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 355 pp 237-249
Copyright © 1984 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Day, T A
Right arrow Articles by Renaud, L P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Day, T A
Right arrow Articles by Renaud, L P

Facilitatory influence of noradrenergic afferents on the excitability of rat paraventricular nucleus neurosecretory cells.

 T A Day, A V Ferguson and L P Renaud

The role of the A1 and A2 noradrenergic cell groups of the caudal medulla in regulating the activity of paraventricular nucleus neurosecretory cells was examined with electrophysiological methods in anaesthetized male Sprague-Dawley rats. Antidromically identified neurosecretory cells were classified as vasopressin or oxytocin secreting on the basis of spontaneous firing patterns and responsivity to baroreceptor activation. The effect on cell firing of single pulses (25-200 microA) delivered to either the A1 or A2 cell group areas was then examined using peri-stimulus histograms. Stimulation of the A1 region enhanced the activity of 78% of putative vasopressin-secreting neurones tested (n = 18), but failed to affect the activity of the majority (73%) of putative oxytocin-secreting units (n = 15). A2 stimulation enhanced the firing rate of both putative vasopressin- (60%, total n = 14) and putative oxytocin-secreting (70%, total n = 27) neurones. Destruction of the paraventricular nucleus catecholamine terminal plexus by pre-treatment with the neurotoxin 6-hydroxydopamine abolished the facilitatory effects of both A1 and A2 stimulation. These findings suggest that noradrenergic afferents of medullary origin facilitate the activity of paraventricular nucleus neurosecretory cells. The role of the projection from the A1 cell group appears to differ from that of the A2 group, however, in that its effects are specific to putative vasopressin-secreting units.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
H. Duale, H. Waki, P. Howorth, S. Kasparov, A. G. Teschemacher, and J. F.R. Paton
Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive rats
Cardiovasc Res, October 1, 2007; 76(1): 184 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. E. Haley and F. W. Flynn
Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R931 - R937.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. R. J. Gordon and J. S. Bains
Can homeostatic circuits learn and remember?
J. Physiol., October 15, 2006; 576(2): 341 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. T. Theodosis, A. Trailin, and D. A. Poulain
Remodeling of astrocytes, a prerequisite for synapse turnover in the adult brain? Insights from the oxytocin system of the hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1175 - R1182.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. R. J. Gordon and J. S. Bains
Noradrenaline Triggers Multivesicular Release at Glutamatergic Synapses in the Hypothalamus
J. Neurosci., December 7, 2005; 25(49): 11385 - 11395.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D.-P. Li, L. M. Atnip, S.-R. Chen, and H.-L. Pan
Regulation of Synaptic Inputs to Paraventricular-Spinal Output Neurons by {alpha}2 Adrenergic Receptors
J Neurophysiol, January 1, 2005; 93(1): 393 - 402.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. R. J. Gordon and J. S. Bains
Priming of Excitatory Synapses by {alpha}1 Adrenoceptor-Mediated Inhibition of Group III Metabotropic Glutamate Receptors
J. Neurosci., July 16, 2003; 23(15): 6223 - 6231.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C.-M. Vacher, P. Fretier, C. Creminon, A. Calas, and H. Hardin-Pouzet
Activation by Serotonin and Noradrenaline of Vasopressin and Oxytocin Expression in the Mouse Paraventricular and Supraoptic Nuclei
J. Neurosci., March 1, 2002; 22(5): 1513 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Kapoor and C. D. Sladek
Purinergic and Adrenergic Agonists Synergize in Stimulating Vasopressin and Oxytocin Release
J. Neurosci., December 1, 2000; 20(23): 8868 - 8875.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Daftary, C. Boudaba, K. Szabo, and J. G. Tasker
Noradrenergic Excitation of Magnocellular Neurons in the Rat Hypothalamic Paraventricular Nucleus via Intranuclear Glutamatergic Circuits
J. Neurosci., December 15, 1998; 18(24): 10619 - 10628.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 The Physiological Society.