J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 364 pp 69-79
Copyright © 1985 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carey, H V
Right arrow Articles by Zafirova, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carey, H V
Right arrow Articles by Zafirova, M

Mucosal responses evoked by stimulation of ganglion cell somas in the submucosal plexus of the guinea-pig ileum.

 H V Carey, H J Cooke and M Zafirova

The effects of electrical field stimulation and tetrodotoxin on the mucosal secretory response were compared in guinea-pig ileal mucosa with and without the submucosal plexus. Short-circuit currents and transmural electrical potential differences were similar in ganglionated and aganglionated tissues. Total tissue conductance was greater after removal of the submucosal ganglia. Electrical field stimulation evoked a tetrodotoxin-sensitive increase in short-circuit current in ganglionated tissues, and little or no response in aganglionated tissues. Both ganglionated and aganglionated tissues responded similarly to carbachol, vasoactive intestinal polypeptide, scorpion venom and alanine. These results suggest that electrical field stimulation of guinea-pig ileum evokes an increase in short-circuit current that reflects chloride secretion by exciting ganglion cell bodies whose axons project to the transporting cells and/or endocrine cells. Direct electrical activation of enteroendocrine cells is not a factor in the stimulus-evoked secretory response.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. E. Reed and S. Vanner
Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G608 - G614.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. D. Chambers, J. C. Bornstein, H. Sjovall, and E. A. Thomas
Recurrent networks of submucous neurons controlling intestinal secretion: a modeling study
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G887 - G896.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Hosoda, S.-I. Karaki, Y. Shimoda, and A. Kuwahara
Substance P-evoked Cl- secretion in guinea pig distal colonic epithelia: interaction with PGE2
Am J Physiol Gastrointest Liver Physiol, August 1, 2002; 283(2): G347 - G356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. J. S. Miller, W. K. MacNaughton, X.-J. Zhang, J. H. Thompson, R. M. Charbonnet, P. Bobrowski, J. Lao, A. M. Trentacosti, and M. Sandoval
Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado
Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G192 - G200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. L. Freeman and W. K. MacNaughton
Ionizing radiation induces iNOS-mediated epithelial dysfunction in the absence of an inflammatory response
Am J Physiol Gastrointest Liver Physiol, February 1, 2000; 278(2): G243 - G250.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 The Physiological Society.