HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Van Driessche, W Search for Related Content PubMed PubMed Citation Articles by Van Driessche, W

1. Basolateral membranes of the frog urinary bladder were investigated after increasing the cationic conductance of the apical membrane by the incorporation of nystatin. 2. K+ currents were recorded in the presence of a mucosa to serosa oriented K+ gradient (SO4(2-) Ringer solution). Nystatin caused a rapid rise of the short-circuit current (Isc) followed by a slow increase over a period of 1-2 h. 3. Impedance analysis showed that the apical membrane resistance was drastically reduced by nystatin. The slow increase in Isc was accompanied by a progressive increase in basolateral conductance. 4. The transepithelial current and conductance recorded in the presence of nystatin could be depressed with lidocaine added to the mucosal and serosal solution. The effects of lidocaine were completely reversible. 5. Noise analysis showed that lidocaine induced additional fluctuations in Isc. The spectrum of these fluctuations was of the Lorentzian type. This noise component is caused by the random interruption of the current through the basolateral K+ channels. The Lorentzian parameters were used to calculate the microscopic parameters of the basolateral K+ channels.

This article has been cited by other articles:

				M. A. Matthay, H. G. Folkesson, and C. Clerici Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema Physiol Rev, July 1, 2002; 82(3): 569 - 600. [Abstract] [Full Text] [PDF]

				P. De Smet, J. Li, and W. Van Driessche Hypotonicity activates a lanthanide-sensitive pathway for K+ release in A6 epithelia Am J Physiol Cell Physiol, July 1, 1998; 275(1): C189 - C199. [Abstract] [Full Text] [PDF]

				S. D. Hillyard, H. F. Cantiello, and W. Van Driessche K+ transport and capacitance of the basolateral membrane of the larval frog skin Am J Physiol Cell Physiol, December 1, 1997; 273(6): C1995 - C2001. [Abstract] [Full Text] [PDF]