HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morton, M J Articles by Thornburg, K L Search for Related Content PubMed PubMed Citation Articles by Morton, M J Articles by Thornburg, K L

Department of Internal Medicine, Oregon Health Sciences University, Portland 97201.

1. In order to determine mechanisms for increased stroke volume at birth, left ventricular function was investigated in eight fetal lambs during in utero pulmonary ventilation. At surgery fetuses were prepared with a tracheal tube, aortic electromagnetic flow sensor, and carotid, jugular, pericardial and left atrial catheters. 2. After 8.3 +/- 1.5 (mean +/- S.D.) post-surgery days and at 137 +/- 3 days gestation, haemodynamic values were obtained before and during pulmonary ventilation in utero. 3. During ventilation, O2 content increased from 7.3 +/- 2.1 to 14.7 +/- 2.7 ml dl-1 (P less than 0.001), right atrial pressure from 3.0 +/- 1.3 to 4.5 +/- 1.6 mmHg (P less than 0.05), left atrial pressure from 2.5 +/- 1.2 to 10.2 +/- 3.7 mmHg (P less than 0.001), left ventricular stroke volume from 1.1 +/- 0.4 to 1.9 +/- 1.2 ml kg-1 (P less than 0.05), and heart rate from 160 +/- 21 to 183 +/- 11 beats min-1 (P less than 0.05). 4. During O2 ventilation, left ventricular function curves relating stroke volume to left atrial pressure were shifted upward. 5. O2 ventilation produced rapid, reversible increases in left ventricular stroke volume which approximate increases in stroke volume at birth.

This article has been cited by other articles:

				G. D. Giraud, S. Louey, S. Jonker, J. Schultz, and K. L. Thornburg Cortisol Stimulates Cell Cycle Activity in the Cardiomyocyte of the Sheep Fetus Endocrinology, August 1, 2006; 147(8): 3643 - 3649. [Abstract] [Full Text] [PDF]

				T. L. Van Natta, J. C. Ralphe, C. E. Mascio, K. A. Bedell, T. D. Scholz, and J. L. Segar Ontogeny of Vascular Growth Factors in Perinatal Sheep Myocardium Reproductive Sciences, December 1, 2004; 11(8): 503 - 510. [Abstract] [PDF]

				A. Barbera, G. D. Giraud, M. D. Reller, J. Maylie, M. J. Morton, and K. L. Thornburg Right ventricular systolic pressure load alters myocyte maturation in fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1157 - R1164. [Abstract] [Full Text] [PDF]