HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bennett, J A Articles by Shepheard, S L Search for Related Content PubMed PubMed Citation Articles by Bennett, J A Articles by Shepheard, S L

Department of Cardiovascular Studies, University of Leeds.

1. Extracellular recordings were made from 123 synaptically activated neurones in the nucleus tractus solitarius of the chloralose-anaesthetized cat. 2. Ninety-one neurones were activated by electrical stimulation of cardiac or pulmonary vagal branches and thirty-two by stimulation of the aortic nerve. 3. Ionophoretic application of GABA abolished or markedly reduced the evoked or spontaneous activity of each neurone tested. These inhibitory effects were antagonized by the simultaneous ionophoretic application of bicuculline. 4. Glycine inhibited the evoked activity of 60% of neurones tested. This inhibition could be antagonized by the simultaneous application of strychnine. 5. Application of bicuculline alone increased the evoked or spontaneous activity of a large proportion of the neurones; strychnine alone had no significant effect on the evoked or spontaneous activity of the neurones. 6. These results are consistent with the hypothesis that GABA acts as an inhibitory transmitter substance within the nucleus tractus solitarius.

This article has been cited by other articles:

				W.-Z. Wang, L. Gao, Y.-X. Pan, I. H. Zucker, and W. Wang AT1 receptors in the nucleus tractus solitarii mediate the interaction between the baroreflex and the cardiac sympathetic afferent reflex in anesthetized rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1137 - R1145. [Abstract] [Full Text] [PDF]

				A. M. Degtyarenko and M. P. Kaufman MLR-induced inhibition of barosensory cells in the NTS Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2575 - H2584. [Abstract] [Full Text] [PDF]

				P. J. Mueller, C. M. Foley, H. W. Vogl, M. Hay, and E. M. Hasser Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R198 - R208. [Abstract] [Full Text] [PDF]

				P. Venkatesan, S. Baxi, C. Evans, R. Neff, X. Wang, and D. Mendelowitz Glycinergic Inputs to Cardiac Vagal Neurons in the Nucleus Ambiguus Are Inhibited by Nociceptin and {micro}-Selective Opioids J Neurophysiol, September 1, 2003; 90(3): 1581 - 1588. [Abstract] [Full Text] [PDF]

				F. F. Pimentel, L. G. H. Bonagamba, and B. H. Machado Pressor response to chemoreflex activation before and after microinjection of glycine into the NTS of awake rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1000 - R1009. [Abstract] [Full Text] [PDF]

				J. Zhang and S. W. Mifflin Subthreshold aortic nerve inputs to neurons in nucleus of the solitary tract Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1595 - R1604. [Abstract] [Full Text] [PDF]