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Department of Physiology, Queen's University of Belfast.

1. Lymphatics draining the region distal to the fetlock were cannulated in anaesthetized sheep. A pneumatic cuff was used to intermittently compress the drainage area. 2. Intermittent inflation of the cuff accelerated lymph flow. This effect increased dramatically as the frequency of inflation was increased. 3. With a constant inflation time, increasing the time between inflations increased the additional volume of lymph expelled per external compression threefold over the range of 0.5-8 s. Longer intervals produced little further change. 4. There was no significant difference between the effects on lymph volume per compression of intermittent cuff inflations lasting from 1 to 18 s with a constant time between inflations. 5. A cuff pressure of 20 mmHg produced a significant rise in lymph flow. Increasing the pressure applied during cuff inflation increased the effect up to the maximum pressure used (320 mmHg). 6. These studies demonstrate that the promotion of lymph formation by tissue compression is related to the number of compressions applied and the period of time between them. Increasing the pressure exaggerates the effect but increasing the length of each compression does not. This suggests that compression empties the terminal lymphatics centripetally. These vessels refill after compression is released and in our preparation this is complete in about 8 s.