J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 398 pp 49-63
Copyright © 1988 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mense, S
Right arrow Articles by Meyer, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mense, S
Right arrow Articles by Meyer, H

Bradykinin-induced modulation of the response behaviour of different types of feline group III and IV muscle receptors.

 S Mense and H Meyer

Anatomisches Institut III, Heidelberg, F.R.G.

1. In order to test the hypothesis that bradykinin has a sensitizing action on muscle receptors (e.g. during a myositis), the response properties of single group III and IV afferent units from the cat gastrocnemius-soleus muscle were compared before and after infiltration of their receptive fields with a bradykinin solution. According to their responses to graded natural stimuli (local pressure, stretch, contractions and temperature changes) the units were classified as (a) nociceptors, (b) low-threshold pressure-sensitive (LTP) receptors, (c) contraction-sensitive (CS) receptors and (d) thermosensitive receptors. 2. Bradykinin activated the majority of both the nociceptive and low-threshold (LTP, CS and thermosensitive) receptors but a sensitization was prominent only among the nociceptors. Most of the sensitized nociceptors showed increased responses to mechanical, but not to thermal, stimuli. The sensitization appeared to be quite specific in that the nociceptors were sensitized either towards local pressure stimulation or to active contractions, but never towards both forms of stimulation. 3. Both group III and group IV nociceptors were sensitized by bradykinin, the proportion of sensitized receptors being greater for group III units. 4. Some of the low-threshold receptors (particularly the CS units) showed a desensitization under the influence of bradykinin. 5. Although bradykinin (by lowering the mechanical thresholds of nociceptors into the innocuous range) could produce the symptom of allodynia, it was not capable of eliciting all the changes in receptor behaviour which are known to occur in inflamed tissues. For instance, no ongoing activity of longer duration and no substantial sensitization of low-threshold receptors have been observed in the present study.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Kindig, S. G. Hayes, and M. P. Kaufman
Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2995 - H3000.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Kindig, S. G. Hayes, R. L. Hanna, and M. P. Kaufman
P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1214 - H1219.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Taguchi, J. Sato, and K. Mizumura
Augmented Mechanical Response of Muscle Thin-Fiber Sensory Receptors Recorded from Rat Muscle-Nerve Preparations In Vitro After Eccentric Contraction
J Neurophysiol, October 1, 2005; 94(4): 2822 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. P. D. Bell and M. J. White
Cardiovascular responses to external compression of human calf muscle vary during graded metaboreflex stimulation
Exp Physiol, May 1, 2005; 90(3): 383 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Taguchi, T. Matsuda, R. Tamura, J. Sato, and K. Mizumura
Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats
J. Physiol., April 1, 2005; 564(1): 259 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. Ge and P. S. Khalsa
Encoding of Compressive Stress During Indentation by Group III and IV Muscle Mechano-Nociceptors in Rat Gracilis Muscle
J Neurophysiol, February 1, 2003; 89(2): 785 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. C. Gandevia
Spinal and Supraspinal Factors in Human Muscle Fatigue
Physiol Rev, October 1, 2001; 81(4): 1725 - 1789.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Avela, H. Kyrolainen, P. V. Komi, and D. Rama
Reduced reflex sensitivity persists several days after long-lasting stretch-shortening cycle exercise
J Appl Physiol, April 1, 1999; 86(4): 1292 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Ray, E. T. Mahoney, and K. M. Hume
Exercise-induced muscle injury augments forearm vascular resistance during leg exercise
Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H443 - H447.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Adreani and M. P. Kaufman
Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise
J Appl Physiol, June 1, 1998; 84(6): 1827 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Ray and K. H. Gracey
Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating
J Appl Physiol, June 1, 1997; 82(6): 1719 - 1733.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 The Physiological Society.