HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Edwards, A V Articles by Jones, C T Search for Related Content PubMed PubMed Citation Articles by Edwards, A V Articles by Jones, C T

Physiological Laboratory, University of Cambridge.

1. The output of corticotrophin releasing factor-like immunoreactivity (CRF) from the adrenal gland has been investigated using the 'adrenal clamp' technique in conscious calves. 2. Stimulation of the peripheral end of the splanchnic nerve for 10 min increased the mean output of CRF progressively, so that it had risen by about twentyfold, to a peak incremental value of 24 +/- 4 pmol min-1 kg-1 at 10 min. This response was significantly increased by stimulating in bursts at 40 Hz for 1 s at 10 s intervals, which raised the mean CRF output by 44 +/- 7 pmol min-1 kg-1 at 10 min (P less than 0.05). 3. The mean output of adrenaline and noradrenaline rose more abruptly in response to splanchnic nerve stimulation with peak incremental values realized within 2.5 min. However, the ratios of adrenal CRF to catecholamine output were closely similar during the later stages of stimulation (7.5-10 min). There was a similarly abrupt rise in adrenal cortisol output in response to splanchnic nerve stimulation which was, nevertheless, linearly related to arterial plasma ACTH concentration throughout. 4. In hypophysectomized calves, administration of adrenocorticotrophic hormone (ACTH1-24) at a dose of 5 ng min-1 kg-1 reduced the output of adrenal CRF in response to splanchnic nerve stimulation by about 50% (P less than 0.05). 5. CRF isolated from adrenal venous effluent plasma, collected both at rest and during splanchnic nerve stimulation, was separated by reverse-phase high-pressure liquid chromatography and found to elute in a position identical to that of human 41CRF. This suggests that adrenal CRF is structurally closely similar to its pituitary counterpart.

This article has been cited by other articles:

				A. Luckey, E. Livingston, and Y. Tache Mechanisms and Treatment of Postoperative Ileus Arch Surg, February 1, 2003; 138(2): 206 - 214. [Abstract] [Full Text] [PDF]

				E. Dermitzaki, C. Tsatsanis, A. Gravanis, and A. N. Margioris Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein Kinase J. Biol. Chem., March 29, 2002; 277(14): 12280 - 12287. [Abstract] [Full Text] [PDF]

				M. Ehrhart-Bornstein, J. P. Hinson, S. R. Bornstein, W. A. Scherbaum, and G. P. Vinson Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis Endocr. Rev., April 1, 1998; 19(2): 101 - 143. [Abstract] [Full Text]

				S. R. Bornstein, E. L. Webster, D. J. Torpy, S. J. Richman, N. Mitsiades, M. Igel, D. B. Lewis, K. C. Rice, H. G. Joost, M. Tsokos, et al. Chronic Effects of a Nonpeptide Corticotropin-Releasing Hormone Type I Receptor Antagonist on Pituitary-Adrenal Function, Body Weight, and Metabolic Regulation Endocrinology, April 1, 1998; 139(4): 1546 - 1555. [Abstract] [Full Text] [PDF]

				M. Venihaki, K. Ain, E. Dermitzaki, A. Gravanis, and A. N. Margioris KAT45, a Noradrenergic Human Pheochromocytoma Cell Line Producing Corticotropin-Releasing Hormone Endocrinology, February 1, 1998; 139(2): 713 - 722. [Abstract] [Full Text] [PDF]

				M. Venihaki, A. Gravanis, and A. N. Margioris Comparative Study between Normal Rat Chromaffin and PC12 Rat Pheochromocytoma Cells: Production and Effects of Corticotropin-Releasing Hormone Endocrinology, February 1, 1997; 138(2): 698 - 704. [Abstract] [Full Text] [PDF]