| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia.
1. The resting membrane potentials of proximal and distal segments of the arterioles which arise from the rat middle cerebral artery were determined. Proximal segments had stable membrane potentials with a mean value of -69 mV. The membrane potentials of distal segments were less negative and often unstable. 2. When the extracellular concentration of potassium ions [( K+]o) was increased proximal segments of arteriole were depolarized whereas distal ones were hyperpolarized. When [K+]o was decreased both proximal and distal segments were depolarized, the changes being more marked in proximal arterioles. 3. The membranes of proximal segments of arteriole displayed inward rectification at potentials near rest; inward rectification in distal segments of arteriole, when detected, was less pronounced. 4. The activation curve for inward rectification in proximal segments of arteriole was changed by changing the extracellular concentration of K+. A reduction in [K+]o caused the activation curve to move to such negative potentials that the inward rectifier no longer contributed to the resting conductance. 5. Increasing [K+]o changed the activation curve for inward rectification in distal segments of arteriole so that more K+ current flowed at potentials near resting. At the same time the membrane potential hyperpolarized. 6. The results are discussed in relation to autoregulatory changes which occur following changes in the K+ concentration of cerebrospinal fluid.
This article has been cited by other articles:
|
|
 |
|
  C. E. Hill Inward rectification and vascular function: As it was in the beginning J. Physiol., March 15, 2008; 586(6): 1465 - 1467. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chilton, K. Loutzenhiser, E. Morales, J. Breaks, G. J. Kargacin, and R. Loutzenhiser Inward Rectifier K+ Currents and Kir2.1 Expression in Renal Afferent and Efferent Arterioles J. Am. Soc. Nephrol., January 1, 2008; 19(1): 69 - 76. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cao, W. Lee-Kwon, K. Payne, A. Edwards, and T. L. Pallone Descending vasa recta endothelia express inward rectifier potassium channels Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1248 - F1255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Filosa and V. M. Blanco Neurovascular coupling in the mammalian brain Exp Physiol, July 1, 2007; 92(4): 641 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Z. Xu, G. Boulay, R. Flemming, and D. J. Beech E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2653 - H2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsushita and D. G. Puro Topographical heterogeneity of KIR currents in pericyte-containing microvessels of the rat retina: effect of diabetes J. Physiol., June 1, 2006; 573(2): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cao, J. H. Goo, W. Lee-Kwon, and T. L. Pallone Vasa recta pericytes express a strong inward rectifier K+ conductance Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1601 - R1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Haddy, P. M. Vanhoutte, and M. Feletou Role of potassium in regulating blood flow and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R546 - R552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakahata, H. Kinoshita, Y. Tokinaga, Y. Ishida, Y. Kimoto, M. Dojo, K. Mizumoto, K. Ogawa, and Y. Hatano Vasodilation Mediated by Inward Rectifier K+ Channels in Cerebral Microvessels of Hypertensive and Normotensive Rats Anesth. Analg., February 1, 2006; 102(2): 571 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Park, J. Han, N. Kim, J.-H. Ko, S. J. Kim, and Y. E Earm Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2461 - H2467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Windmuller, U. Lindauer, M. Foddis, K. M. Einhaupl, U. Dirnagl, U. Heinemann, and J. P. Dreier Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO Brain, September 1, 2005; 128(9): 2042 - 2051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schubert, U. Krien, I. Wulfsen, D. Schiemann, G. Lehmann, N. Ulfig, R. W. Veh, J. R. Schwarz, and H. Gago Nitric Oxide Donor Sodium Nitroprusside Dilates Rat Small Arteries by Activation of Inward Rectifier Potassium Channels Hypertension, April 1, 2004; 43(4): 891 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Seol, S. C. Ahn, J. A. Kim, B. Nilius, and S. H. Suh Inhibition of endothelium-dependent vasorelaxation by extracellular K+: a novel controlling signal for vascular contractility Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H329 - H339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Stanfield and M. J. Sutcliffe Spermine Is Fit to Block Inward Rectifier (Kir) Channels J. Gen. Physiol., October 27, 2003; 122(5): 481 - 484. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vigili de Kreutzenberg, E. Kiwanuka, A. Tiengo, and A. Avogaro Visceral obesity is characterized by impaired nitric oxide-independent vasodilation Eur. Heart J., July 1, 2003; 24(13): 1210 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. I. Rosenblum ATP-Sensitive Potassium Channels in the Cerebral Circulation Stroke, June 1, 2003; 34(6): 1547 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Karkanis, S. Li, J. G. Pickering, and S. M. Sims Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2325 - H2334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chrissobolis, J. Ziogas, C. R. Anderson, Y. Chu, F. M. Faraci, and C. G. Sobey Neuronal NO Mediates Cerebral Vasodilator Responses to K+ in Hypertensive Rats Hypertension, April 1, 2002; 39(4): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Oonuma, K. Iwasawa, H. Iida, T. Nagata, H. Imuta, Y. Morita, K. Yamamoto, R. Nagai, M. Omata, and T. Nakajima Inward Rectifier K+ Current in Human Bronchial Smooth Muscle Cells . Inhibition with Antisense Oligonucleotides Targeted to Kir2.1 mRNA Am. J. Respir. Cell Mol. Biol., March 1, 2002; 26(3): 371 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Eckman and M. T. Nelson Potassium Ions as Vasodilators: Role of Inward Rectifier Potassium Channels Circ. Res., February 2, 2001; 88(2): 132 - 133. [Full Text] [PDF]
|
|
|
|
|
|
L. Chilton and R. Loutzenhiser Functional Evidence for an Inward Rectifier Potassium Current in Rat Renal Afferent Arterioles Circ. Res., February 2, 2001; 88(2): 152 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Sobey Potassium Channel Function in Vascular Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 28 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Horiuchi, H. H. Dietrich, S. Tsugane, R. G. Dacey Jr, C. G. Sobey, and F. M. Faraci Role of Potassium Channels in Regulation of Brain Arteriolar Tone : Comparison of Cerebrum Versus Brain Stem Editorial Comment: Comparison of Cerebrum Versus Brain Stem Stroke, January 1, 2001; 32(1): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Long, L. Zhang, and L. D. Longo Cerebral artery KATP- and KCa-channel activity and contractility: changes with development Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2004 - R2014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chrissobolis, J. Ziogas, Y. Chu, F. M. Faraci, and C. G. Sobey Role of inwardly rectifying K+ channels in K+-induced cerebral vasodilatation in vivo Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2704 - H2712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ji, A. M. F. Salapatek, and N. E. Diamant Inwardly rectifying K+ channels in esophageal smooth muscle Am J Physiol Gastrointest Liver Physiol, November 1, 2000; 279(5): G951 - G960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Sobey and F. M. Faraci Knockout Blow for Channel Identity Crisis : Vasodilation to Potassium Is Mediated via Kir2.1 Circ. Res., July 21, 2000; 87(2): 83 - 84. [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zaritsky, D. M. Eckman, G. C. Wellman, M. T. Nelson, and T. L. Schwarz Targeted Disruption of Kir2.1 and Kir2.2 Genes Reveals the Essential Role of the Inwardly Rectifying K+ Current in K+-Mediated Vasodilation Circ. Res., July 21, 2000; 87(2): 160 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Quinn, C. Guibert, and D. J. Beech Sodium-potassium-ATPase electrogenicity in cerebral precapillary arterioles Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H351 - H360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Jackson Ion Channels and Vascular Tone Hypertension, January 1, 2000; 35(1): 173 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davis and M. A. Hill Signaling Mechanisms Underlying the Vascular Myogenic Response Physiol Rev, April 1, 1999; 79(2): 387 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. KURIYAMA, K. KITAMURA, T. ITOH, and R. INOUE Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels Physiol Rev, July 1, 1998; 78(3): 811 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Marrelli, T. D. Johnson, A. Khorovets, W. F. Childres, R. M. Bryan Jr, and D. W. Busija Altered Function of Inward Rectifier Potassium Channels in Cerebrovascular Smooth Muscle After Ischemia/Reperfusion • Editorial Comment Stroke, July 1, 1998; 29(7): 1469 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Johnson, S. P. Marrelli, M. L. Steenberg, W. F. Childres, and R. M. Bryan Jr. Inward rectifier potassium channels in the rat middle cerebral artery Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R541 - R547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Onoue and Z. S. Katusic Role of Potassium Channels in Relaxations of Canine Middle Cerebral Arteries Induced by Nitric Oxide Donors Stroke, June 1, 1997; 28(6): 1264 - 1271. [Abstract] [Full Text]
|
|
|
|
|
|
N. I. Gokina, R. D. Bevan, C. L. Walters, and J. A. Bevan Electrical Activity Underlying Rhythmic Contraction in Human Pial Arteries Circ. Res., January 1, 1996; 78(1): 148 - 153. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad Role of Potassium Channels in Cerebral Blood Vessels Stroke, September 1, 1995; 26(9): 1713 - 1723. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
