HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCormick, D A Articles by Pape, H C Search for Related Content PubMed PubMed Citation Articles by McCormick, D A Articles by Pape, H C

Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.

1. Modulation of the hyperpolarization-activated cation current, Ih, by noradrenaline (NA) and serotonin (5-HT) was examined in guinea-pig and cat medial and lateral geniculate relay neurones using the in vitro slice technique. 2. In the absence of pharmacological antagonists, local application of NA resulted in a slow depolarization and decrease in apparent input conductance, a response which was blocked by local or bath application of the alpha 1-adrenoceptor antagonist prazosin. Application of NA after pharmacological block of alpha 1- and alpha 2-adrenoceptors, or application of 5-HT in all conditions, induced a 1-3 mV slow depolarization which was associated with a pronounced increase in apparent input conductance. This response to NA and 5-HT persisted during blocked synaptic transmission and was present in both the guinea-pig and cat medial and lateral geniculate nuclei. 3. The increase in membrane conductance elicited by NA was mimicked by the beta-specific agonist isoprenaline and blocked by the beta-antagonists propranolol and atenolol, indicating that it is mediated by beta-adrenoceptors. The response to 5-HT was blocked by the 5-HT1 and 5-HT2 antagonist methysergide, but not by the 5-HT2 antagonist ritanserin. Applications of either the 5-HT1A agonist ipsapirone or the partial agonist 8-hydroxy-dipropylaminotetralin (8-OHDPAT) were without effect. 4. Current versus voltage relationships obtained under voltage clamp revealed NA and 5-HT to cause a voltage-dependent inward shift at membrane potentials negative to approximately -60 mV. This response appeared to be shared by NA and 5-HT since maximal application of 5-HT greatly reduced or abolished the response to NA. 5. Application of NA and/or 5-HT during hyperpolarizing voltage steps in voltage clamp resulted in a marked increase in amplitude of the hyperpolarization-activated cation current, Ih. In addition, the rate of activation of Ih was strongly increased during activation of beta-adrenoceptors. 6. The activation curve of the conductance underlying Ih (Gh) was shifted by 4-6 mV on the voltage axis with NA and/or 5-HT. The positive shift of Gh activation in the voltage domain resulted in an increase in the amplitude of Gh which is active at resting, and more hyperpolarized, membrane potentials. The subsequent increase in resting membrane conductance decreased the responsiveness of thalamic neurones to hyperpolarizations of all durations. 7. Local or bath application of caesium blocked both Ih and the increase in membrane conductance in response to NA and 5-HT. By contrast, barium blocked neither Ih nor the responses to NA and 5-HT.(ABSTRACT TRUNCATED AT 400 WORDS)

This article has been cited by other articles:

				M. A. Starr, M. E. Page, and B. D. Waterhouse MDMA (3,4-Methylenedioxymethamphetamine)-Mediated Distortion of Somatosensory Signal Transmission and Neurotransmitter Efflux in the Ventral Posterior Medial Thalamus J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 20 - 31. [Abstract] [Full Text] [PDF]

				A. G. Shaikh, K. Miura, L. M. Optican, S. Ramat, R. J. Leigh, and D. S. Zee A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders Brain, November 1, 2007; 130(11): 3020 - 3031. [Abstract] [Full Text] [PDF]

				A. L. Person and D. J. Perkel Pallidal Neuron Activity Increases during Sensory Relay through Thalamus in a Songbird Circuit Essential for Learning J. Neurosci., August 8, 2007; 27(32): 8687 - 8698. [Abstract] [Full Text] [PDF]

				S. K. Jankelowitz, J. Howells, and D. Burke Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects J. Physiol., June 15, 2007; 581(3): 927 - 940. [Abstract] [Full Text] [PDF]

				X.-J. Cao, S. Shatadal, and D. Oertel Voltage-Sensitive Conductances of Bushy Cells of the Mammalian Ventral Cochlear Nucleus J Neurophysiol, June 1, 2007; 97(6): 3961 - 3975. [Abstract] [Full Text] [PDF]

				D. M. Devilbiss, M. E. Page, and B. D. Waterhouse Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals J. Neurosci., September 27, 2006; 26(39): 9860 - 9872. [Abstract] [Full Text] [PDF]

				A.F.T. Arnsten and S. Vijayraghavan Staying in Touch With Methylphenidate: AHDH and Sensory Processing. Focus on "Methylphenidate Enhances Noradrenergic Transmission and Suppresses Mid- and Long-Latency Sensory Responses in the Primary Somatosensory Cortex of Awake Rats" J Neurophysiol, August 1, 2006; 96(2): 524 - 525. [Full Text] [PDF]

				S.-H. Lee and C. L. Cox Excitatory Actions of Vasoactive Intestinal Peptide on Mouse Thalamocortical Neurons Are Mediated by VPAC2 Receptors J Neurophysiol, August 1, 2006; 96(2): 858 - 871. [Abstract] [Full Text] [PDF]

				C. Drouin, M. Page, and B. Waterhouse Methylphenidate Enhances Noradrenergic Transmission and Suppresses Mid- and Long-Latency Sensory Responses in the Primary Somatosensory Cortex of Awake Rats J Neurophysiol, August 1, 2006; 96(2): 622 - 632. [Abstract] [Full Text] [PDF]

				A. Hirata, J. Aguilar, and M. A. Castro-Alamancos Noradrenergic activation amplifies bottom-up and top-down signal-to-noise ratios in sensory thalamus. J. Neurosci., April 19, 2006; 26(16): 4426 - 4436. [Abstract] [Full Text] [PDF]

				C. R. Lupica and M. S. Brodie Queer Currents, Steady Rhythms, and Drunken DA Neurons. Focus on "Hyperpolarization-Activated Cation Current (Ih) Is an Ethanol Target in Midbrain Dopamine Neurons of Mice" J Neurophysiol, February 1, 2006; 95(2): 585 - 586. [Full Text] [PDF]

				T. R. Anderson, B. Hu, K. Iremonger, and Z. H. T. Kiss Selective Attenuation of Afferent Synaptic Transmission as a Mechanism of Thalamic Deep Brain Stimulation-Induced Tremor Arrest J. Neurosci., January 18, 2006; 26(3): 841 - 850. [Abstract] [Full Text] [PDF]

				A. R. A. Rodrigues and D. Oertel Hyperpolarization-Activated Currents Regulate Excitability in Stellate Cells of the Mammalian Ventral Cochlear Nucleus J Neurophysiol, January 1, 2006; 95(1): 76 - 87. [Abstract] [Full Text] [PDF]

				G. Govindaiah and C. L. Cox Excitatory Actions of Dopamine Via D1-Like Receptors in the Rat Lateral Geniculate Nucleus J Neurophysiol, December 1, 2005; 94(6): 3708 - 3718. [Abstract] [Full Text] [PDF]

				T. Budde, L. Caputi, T. Kanyshkova, R. Staak, C. Abrahamczik, T. Munsch, and H.-C. Pape Impaired Regulation of Thalamic Pacemaker Channels through an Imbalance of Subunit Expression in Absence Epilepsy J. Neurosci., October 26, 2005; 25(43): 9871 - 9882. [Abstract] [Full Text] [PDF]

				Z.-w. Zhang and D. Arsenault Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex J. Physiol., July 15, 2005; 566(2): 379 - 394. [Abstract] [Full Text] [PDF]

				P. A Rhodes and R. Llinas A model of thalamocortical relay cells J. Physiol., June 15, 2005; 565(3): 765 - 781. [Abstract] [Full Text] [PDF]

				Z. Xiang, L. Wang, and S. T. Kitai Modulation of Spontaneous Firing in Rat Subthalamic Neurons by 5-HT Receptor Subtypes J Neurophysiol, March 1, 2005; 93(3): 1145 - 1157. [Abstract] [Full Text] [PDF]

				S. Bandyopadhyay, C. Gonzalez-Islas, and J. J. Hablitz Dopamine Enhances Spatiotemporal Spread of Activity in Rat Prefrontal Cortex J Neurophysiol, February 1, 2005; 93(2): 864 - 872. [Abstract] [Full Text] [PDF]

				K. G. Shields and P. J. Goadsby Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine? Brain, January 1, 2005; 128(1): 86 - 97. [Abstract] [Full Text] [PDF]

				D. P. Seeburg, X. Liu, and C. Chen Frequency-Dependent Modulation of Retinogeniculate Transmission by Serotonin J. Neurosci., December 1, 2004; 24(48): 10950 - 10962. [Abstract] [Full Text] [PDF]

				I. van Welie, J. A. van Hooft, and W. J. Wadman Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Ih channels PNAS, April 6, 2004; 101(14): 5123 - 5128. [Abstract] [Full Text] [PDF]

				M. Le Bon-Jego, D. Cattaert, and E. Pearlstein Serotonin Enhances the Resistance Reflex of the Locomotor Network of the Crayfish through Multiple Modulatory Effects that Act Cooperatively J. Neurosci., January 14, 2004; 24(2): 398 - 411. [Abstract] [Full Text] [PDF]

				S. G. A. Frere and A. Luthi Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis J. Physiol., January 1, 2004; 554(1): 111 - 125. [Abstract] [Full Text] [PDF]

				Z. Liu, E. B. Bunney, S. B. Appel, and M. S. Brodie Serotonin Reduces the Hyperpolarization-Activated Current (Ih) in Ventral Tegmental Area Dopamine Neurons: Involvement of 5-HT2 Receptors and Protein Kinase C J Neurophysiol, November 1, 2003; 90(5): 3201 - 3212. [Abstract] [Full Text] [PDF]

				Y. Komagiri and N. Kitamura Effect of Intracellular Dialysis of ATP on the Hyperpolarization-Activated Cation Current in Rat Dorsal Root Ganglion Neurons J Neurophysiol, October 1, 2003; 90(4): 2115 - 2122. [Abstract] [Full Text] [PDF]

				S.-H. Lee and C. L. Cox Vasoactive Intestinal Peptide Selectively Depolarizes Thalamic Relay Neurons and Attenuates Intrathalamic Rhythmic Activity J Neurophysiol, August 1, 2003; 90(2): 1224 - 1234. [Abstract] [Full Text] [PDF]

				J. Li, M. E. Bickford, and W. Guido Distinct Firing Properties of Higher Order Thalamic Relay Neurons J Neurophysiol, July 1, 2003; 90(1): 291 - 299. [Abstract] [Full Text] [PDF]

				C. Chen and W. G. Regehr Presynaptic Modulation of the Retinogeniculate Synapse J. Neurosci., April 15, 2003; 23(8): 3130 - 3135. [Abstract] [Full Text] [PDF]

				Z.-w. Zhang Serotonin Induces Tonic Firing in Layer V Pyramidal Neurons of Rat Prefrontal Cortex during Postnatal Development J. Neurosci., April 15, 2003; 23(8): 3373 - 3384. [Abstract] [Full Text] [PDF]

				Q.-Q. Sun, D. A. Prince, and J. R. Huguenard Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide Activate Hyperpolarization-Activated Cationic Current and Depolarize Thalamocortical Neurons In Vitro J. Neurosci., April 1, 2003; 23(7): 2751 - 2758. [Abstract] [Full Text] [PDF]

				P. Fenik and S. C. Veasey Pharmacological Characterization of Serotonergic Receptor Activity in the Hypoglossal Nucleus Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 563 - 569. [Abstract] [Full Text] [PDF]

				M. Mock, C. Schwarz, and P. Thier Serotonergic Control of Cerebellar Mossy Fiber Activity by Modulation of Signal Transfer by Rat Pontine Nuclei Neurons J Neurophysiol, August 1, 2002; 88(2): 549 - 564. [Abstract] [Full Text] [PDF]

				J. E. Monckton and D. A. McCormick Neuromodulatory Role of Serotonin in the Ferret Thalamus J Neurophysiol, April 1, 2002; 87(4): 2124 - 2136. [Abstract] [Full Text] [PDF]

				D. J. Uhlrich, K. A. Manning, and J.-T. Xue Effects of Activation of the Histaminergic Tuberomammillary Nucleus on Visual Responses of Neurons in the Dorsal Lateral Geniculate Nucleus J. Neurosci., February 1, 2002; 22(3): 1098 - 1107. [Abstract] [Full Text] [PDF]

				C. R. Lupica, J. A. Bell, A. F. Hoffman, and P. L. Watson Contribution of the Hyperpolarization-Activated Current (Ih) to Membrane Potential and GABA Release in Hippocampal Interneurons J Neurophysiol, July 1, 2001; 86(1): 261 - 268. [Abstract] [Full Text] [PDF]

				E. M. Chapin and R. Andrade A 5-HT7 Receptor-Mediated Depolarization in the Anterodorsal Thalamus. II. Involvement of the Hyperpolarization-Activated Current Ih J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 403 - 409. [Abstract] [Full Text]

				F. Saitow, S.'I. Satake, J. Yamada, and S. Konishi beta -Adrenergic Receptor-Mediated Presynaptic Facilitation of Inhibitory GABAergic Transmission at Cerebellar Interneuron-Purkinje Cell Synapses J Neurophysiol, October 1, 2000; 84(4): 2016 - 2025. [Abstract] [Full Text] [PDF]

				W. Kilb and H. J. Luhmann Characterization of a Hyperpolarization-Activated Inward Current in Cajal-Retzius Cells in Rat Neonatal Neocortex J Neurophysiol, September 1, 2000; 84(3): 1681 - 1691. [Abstract] [Full Text] [PDF]

				R. Bal and D. Oertel Hyperpolarization-Activated, Mixed-Cation Current (Ih) in Octopus Cells of the Mammalian Cochlear Nucleus J Neurophysiol, August 1, 2000; 84(2): 806 - 817. [Abstract] [Full Text] [PDF]

				J. C. Brumberg, L. G. Nowak, and D. A. McCormick Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons J. Neurosci., July 1, 2000; 20(13): 4829 - 4843. [Abstract] [Full Text] [PDF]

				G. D. Smith, C. L. Cox, S. M. Sherman, and J. Rinzel Fourier Analysis of Sinusoidally Driven Thalamocortical Relay Neurons and a Minimal Integrate-and-Fire-or-Burst Model J Neurophysiol, January 1, 2000; 83(1): 588 - 610. [Abstract] [Full Text] [PDF]

				M. J. Millan, A. Gobert, A. Newman-Tancredi, F. Lejeune, D. Cussac, J.-M. Rivet, V. Audinot, A. Adhumeau, M. Brocco, J.-P. Nicolas, et al. S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at alpha 1- and alpha 2-Adrenergic Receptors: I. Receptorial, Neurochemical, and Electrophysiological Profile J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 38 - 53. [Abstract] [Full Text]

				M. J. Millan, M. Brocco, J.-M. Rivet, V. Audinot, A. Newman-Tancredi, L. Maiofiss, S. Queriaux, N. Despaux, J.-L. Peglion, and A. Dekeyne S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at alpha 1- and alpha 2-Adrenergic Receptors: II. Functional Profile and a Multiparametric Comparison with Haloperidol, Clozapine, and 11 Other Antipsychotic Agents J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 54 - 66. [Abstract] [Full Text]

				H. Yanagida, R. Inoue, M. Tanaka, and Y. Ito Temperature-sensitive gating of cation current in guinea pig ileal muscle activated by hyperpolarization Am J Physiol Cell Physiol, January 1, 2000; 278(1): C40 - C48. [Abstract] [Full Text] [PDF]

				L. M. Hurley and G. D. Pollak Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus J. Neurosci., September 15, 1999; 19(18): 8071 - 8082. [Abstract] [Full Text] [PDF]

				K. K. Fitzgerald and D. H. Sanes Serotonergic Modulation of Synapses in the Developing Gerbil Lateral Superior Olive J Neurophysiol, June 1, 1999; 81(6): 2743 - 2752. [Abstract] [Full Text] [PDF]

				E. L. Bartlett and P. H. Smith Anatomic, Intrinsic, and Synaptic Properties of Dorsal and Ventral Division Neurons in Rat Medial Geniculate Body J Neurophysiol, May 1, 1999; 81(5): 1999 - 2016. [Abstract] [Full Text] [PDF]

				G. Vargas and M. T. Lucero Dopamine Modulates Inwardly Rectifying Hyperpolarization-Activated Current (Ih) in Cultured Rat Olfactory Receptor Neurons J Neurophysiol, January 1, 1999; 81(1): 149 - 158. [Abstract] [Full Text] [PDF]

				V. M. Sandler and W. N. Ross Serotonin Modulates Spike Backpropagation and Associated [Ca2+]i Changes in the Apical Dendrites of Hippocampal CA1 Pyramidal Neurons J Neurophysiol, January 1, 1999; 81(1): 216 - 224. [Abstract] [Full Text] [PDF]

				J. C. Magee Dendritic Hyperpolarization-Activated Currents Modify the Integrative Properties of Hippocampal CA1 Pyramidal Neurons J. Neurosci., October 1, 1998; 18(19): 7613 - 7624. [Abstract] [Full Text] [PDF]

				K. R. Svoboda and C. R. Lupica Opioid Inhibition of Hippocampal Interneurons via Modulation of Potassium and Hyperpolarization-Activated Cation (Ih) Currents J. Neurosci., September 15, 1998; 18(18): 7084 - 7098. [Abstract] [Full Text] [PDF]

				M. J. Millan, R. Schreiber, A. Dekeyne, J.-M. Rivet, K. Bervoets, M. Mavridis, C. Sebban, S. Maurel-Remy, A. Newman-Tancredi, M. Spedding, et al. S 16924 ((R)-2-{1-[2-(2,3-Dihydro-Benzo[1,4] Dioxin-5-Yloxy)-Ethyl]-Pyrrolidin-3yl}-1-(4-Fluoro-Phenyl)-Ethanone), a Novel, Potential Antipsychotic with Marked Serotonin (5-HT)1A Agonist Properties: II. Functional Profile in Comparison to Clozapine and Haloperidol J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1356 - 1373. [Abstract] [Full Text]

				G. Erdemli and V. Crunelli Response of Thalamocortical Neurons to Hypoxia: A Whole-Cell Patch-Clamp Study J. Neurosci., July 15, 1998; 18(14): 5212 - 5224. [Abstract] [Full Text] [PDF]

				G. Stuart and N. Spruston Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites J. Neurosci., May 15, 1998; 18(10): 3501 - 3510. [Abstract] [Full Text] [PDF]

				M. S. Jafri and D. Weinreich Substance P Regulates Ih via a NK-1 Receptor in Vagal Sensory Neurons of the Ferret J Neurophysiol, February 1, 1998; 79(2): 769 - 777. [Abstract] [Full Text] [PDF]

				Z.-L. Mo and R. L. Davis Heterogeneous Voltage Dependence of Inward Rectifier Currents in Spiral Ganglion Neurons J Neurophysiol, December 1, 1997; 78(6): 3019 - 3027. [Abstract] [Full Text] [PDF]

				S. Williams, M. Serafin, M. Muhlethaler, and L. Bernheim Distinct Contributions of High- and Low-Voltage-Activated Calcium Currents to Afterhyperpolarizations in Cholinergic Nucleus Basalis Neurons of the Guinea Pig J. Neurosci., October 1, 1997; 17(19): 7307 - 7315. [Abstract] [Full Text] [PDF]

				M. Pirchio, J. P. Turner, S. R. Williams, E. Asprodini, and V. Crunelli Postnatal Development of Membrane Properties and delta  Oscillations in Thalamocortical Neurons of the Cat Dorsal Lateral Geniculate Nucleus J. Neurosci., July 15, 1997; 17(14): 5428 - 5444. [Abstract] [Full Text] [PDF]

				P. C. Schwindt and W. E. Crill Modification of Current Transmitted From Apical Dendrite to Soma by Blockade of Voltage- and Ca2+-Dependent Conductances in Rat Neocortical Pyramidal Neurons J Neurophysiol, July 1, 1997; 78(1): 187 - 198. [Abstract] [Full Text] [PDF]

				C. F. Hsiao, P. R. Trueblood, M. S. Levine, and S. H. Chandler Multiple Effects of Serotonin on Membrane Properties of Trigeminal Motoneurons In Vitro J Neurophysiol, June 1, 1997; 77(6): 2910 - 2924. [Abstract] [Full Text] [PDF]

T. Bal and D. A. McCormick Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current Ih J Neurophysiol, June 1, 1997; 77(6): 3145 - 3156. [Abstract] [Full Text] [PDF]