HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huang, Q Articles by St John, W M Search for Related Content PubMed PubMed Citation Articles by Huang, Q Articles by St John, W M

Department of Physiology, Dartmouth Medical School, Hanover, NH 03756.

1. The purpose of our investigation was to evaluate the hypothesis that components of the vestibular and cerebellar systems regulate efferent respiratory-modulated activities of cranial and spinal nerves. The hypothesis was based upon the observation that spinal neural activities during expiration are greatly altered subsequent to a change in posture. 2. In decerebrate and paralysed cats, efferent activities were recorded from the central cut ends of the phrenic nerve, intercostal nerve, branch of the intercostal nerve innervating the triangularis sterni, cranial iliohypogastric (abdominal) nerve and recurrent laryngeal nerve. 3. Animals were artificially ventilated. Those with intact vagi were ventilated by a servo-respirator which produced changes in lung volume in parallel with alterations in integrated activity of the phrenic nerve. Animals with bilateral vagotomy were ventilated with a standard respirator. 4. Aspiration of the entire cerebellar cortex did not produce alterations in levels of neural activities; the respiratory frequency was increased modestly. Following ablation of the ventrolateral portion of corpus medullare and cerebellar peduncles, expiratory activities of spinal nerves were completely eliminated whereas inspiratory activities were not greatly altered. Results were similar in animals having either intact or sectioned vagi. 5. Electrical stimulation or chemical stimulation by glutamate of regions of the ventrolateral cerebellum produced little change in respiratory neural activities except when these stimulations were within the infracerebellar nucleus. Stimulations in this nucleus caused pronounced increases in expiratory activities of spinal nerves. Neither inspiratory activities of spinal nerves nor inspiratory or expiratory activities of the recurrent laryngeal nerve were altered. Studies in animals having intact or sectioned vagi yielded similar results. 6. Bilateral lesions of neurons in the infracerebellar nucleus by injections of kainic acid in animals having intact or sectioned vagi caused an irreversible loss of expiratory activities of spinal nerves with neither inspiratory spinal activities nor inspiratory and expiratory laryngeal activities being altered. Similar findings were obtained following unilateral ablation of the infracerebellar nucleus in vagotomized cats. However, in cats with intact vagi, unilateral ablation of the infracerebellar nucleus produced only transient changes in either inspiratory or expiratory neural activities.(ABSTRACT TRUNCATED AT 400 WORDS)

This article has been cited by other articles:

				P. F. Martino, S. Davis, C. Opansky, K. Krause, J. M. Bonis, S. G. Czerniak, L. G. Pan, B. Qian, and H. V. Forster Lesions in the cerebellar fastigial nucleus have a small effect on the hyperpnea needed to meet the gas exchange requirements of submaximal exercise J Appl Physiol, October 1, 2006; 101(4): 1199 - 1206. [Abstract] [Full Text] [PDF]

				J. P. Hernandez, F. Xu, and D. T. Frazier Medial vestibular nucleus mediates the cardiorespiratory responses to fastigial nuclear activation and hypercapnia J Appl Physiol, September 1, 2004; 97(3): 835 - 842. [Abstract] [Full Text] [PDF]

				S. CORNE, K. WEBSTER, G. MCGINN, W. ST.- JOHN, and M. YOUNES Medullary Metastasis Causing Impairment of Respiratory Pressure Output with Intact Respiratory Rhythm Am. J. Respir. Crit. Care Med., January 1, 1999; 159(1): 315 - 320. [Abstract] [Full Text]

				F. Xu, Z. Zhang, and D. T. Frazier Transient respiratory augmentation elicited by acute head-down tilt in the anesthetized cat J Appl Physiol, August 1, 1998; 85(2): 490 - 496. [Abstract] [Full Text] [PDF]

				F. Xu, D. T. Frazier, Z. Zhang, D. M. Baekey, and R. Shannon Cerebellar modulation of cough motor pattern in cats J Appl Physiol, August 1, 1997; 83(2): 391 - 397. [Abstract] [Full Text] [PDF]

				K. D. Monahan, M. K. Sharpe, D. Drury, A. C. Ertl, and C. A. Ray Influence of vestibular activation on respiration in humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R689 - R694. [Abstract] [Full Text] [PDF]