HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baskys, A Articles by Malenka, R C Search for Related Content PubMed PubMed Citation Articles by Baskys, A Articles by Malenka, R C

Department of Psychiatry, University of California, San Francisco 94143.

1. The effects of metabotropic glutamate receptor agonists on excitatory synaptic transmission in the CA1 region of rat hippocampal slices (11-30 days) were studied using extracellular and whole-cell patch-clamp recording techniques. 2. Trans-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD; 25-100 microM) reversibly depressed excitatory postsynaptic currents (EPSCs) without affecting presynaptic fibre excitability or EPSC reversal potential. 3. Ibotenate (25 microM) or L-glutamate (250 microM), in the presence of the N-methyl-D-aspartate (NMDA) receptor antagonist, D-2-amino-5-phosphonovaleric acid (APV, 50-75 microM), depressed the EPSC amplitude while inducing no detectable inward current. L-2-Amino-4-phosphonobutyrate (L-AP4, 25-100 microM), the phosphonic derivative of glutamate, also depressed EPSC amplitude and caused no detectable inward current. 4. The NMDA receptor-mediated component of the EPSC recorded in the presence of the non-NMDA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 20-30 microM) was depressed by trans-ACPD, L-AP4, or quisqualate (1-2 microM). 5. The response to ionophoretic application of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) was unaffected by trans-ACPD or L-AP4 although the simultaneously recorded EPSC was strongly depressed. In addition, paired-pulse facilitation (50-75 ms interstimulus interval) was reversibly enhanced by trans-ACPD or L-AP4. These results indicate that the depression of synaptic transmission likely was mediated by a presynaptic 'autoreceptor'. 6. The effects of trans-ACPD or L-AP4 on synaptic transmission decreased significantly over ages 12-30 days and were minimal in adult (greater than 80 days) slices. 7. The depression of synaptic transmission caused by trans-ACPD or L-AP4 was not altered following the induction of long-term potentiation (LTP). 8. The results indicate that metabotropic glutamate receptor agonists suppress excitatory synaptic transmission in CA1 pyramidal cells by an action at a presynaptic site. This effect is developmentally regulated and is maximally expressed during the first postnatal month.

This article has been cited by other articles:

				A. Madayag, D. Lobner, K. S. Kau, J. R. Mantsch, O. Abdulhameed, M. Hearing, M. D. Grier, and D. A. Baker Repeated N-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine J. Neurosci., December 19, 2007; 27(51): 13968 - 13976. [Abstract] [Full Text] [PDF]

				M. Andersson, F. Blomstrand, and E. Hanse Astrocytes play a critical role in transient heterosynaptic depression in the rat hippocampal CA1 region J. Physiol., December 15, 2007; 585(3): 843 - 852. [Abstract] [Full Text] [PDF]

				K. E. Gipson and M. F. Yeckel Coincident Glutamatergic and Cholinergic Inputs Transiently Depress Glutamate Release at Rat Schaffer Collateral Synapses J Neurophysiol, June 1, 2007; 97(6): 4108 - 4119. [Abstract] [Full Text] [PDF]

				F. Ferraguti, T. Klausberger, P. Cobden, A. Baude, J. D. B. Roberts, P. Szucs, A. Kinoshita, R. Shigemoto, P. Somogyi, and Y. Dalezios Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus J. Neurosci., November 9, 2005; 25(45): 10520 - 10536. [Abstract] [Full Text] [PDF]

				P. J. Mueller, C. M. Foley, H. W. Vogl, M. Hay, and E. M. Hasser Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R198 - R208. [Abstract] [Full Text] [PDF]

				B. Billups, B. P Graham, A. Y. C Wong, and I. D Forsythe Unmasking group III metabotropic glutamate autoreceptor function at excitatory synapses in the rat CNS J. Physiol., June 15, 2005; 565(3): 885 - 896. [Abstract] [Full Text] [PDF]

				S.-R. Chen and H.-L. Pan Distinct Roles of Group III Metabotropic Glutamate Receptors in Control of Nociception and Dorsal Horn Neurons in Normal and Nerve-Injured Rats J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 120 - 126. [Abstract] [Full Text] [PDF]

				A. Scheuber, R. Miles, and J. C. Poncer Presynaptic Cav2.1 and Cav2.2 Differentially Influence Release Dynamics at Hippocampal Excitatory Synapses J. Neurosci., November 17, 2004; 24(46): 10402 - 10409. [Abstract] [Full Text] [PDF]

				J. P. Tyszkiewicz, Z. Gu, X. Wang, X. Cai, and Z. Yan Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex J. Physiol., February 1, 2004; 554(3): 765 - 777. [Abstract] [Full Text] [PDF]

				R. Bertram, J. Swanson, M. Yousef, Z.-P. Feng, and G. W. Zamponi A Minimal Model for G Protein-Mediated Synaptic Facilitation and Depression J Neurophysiol, September 1, 2003; 90(3): 1643 - 1653. [Abstract] [Full Text] [PDF]

				G. R. J. Gordon and J. S. Bains Priming of Excitatory Synapses by {alpha}1 Adrenoceptor-Mediated Inhibition of Group III Metabotropic Glutamate Receptors J. Neurosci., July 16, 2003; 23(15): 6223 - 6231. [Abstract] [Full Text] [PDF]

				C. Millan, E. Castro, M. Torres, R. Shigemoto, and J. Sanchez-Prieto Co-expression of Metabotropic Glutamate Receptor 7 and N-type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats J. Biol. Chem., June 20, 2003; 278(26): 23955 - 23962. [Abstract] [Full Text] [PDF]

				D. A. Baker, Z.-X. Xi, H. Shen, C. J. Swanson, and P. W. Kalivas The Origin and Neuronal Function of In Vivo Nonsynaptic Glutamate J. Neurosci., October 15, 2002; 22(20): 9134 - 9141. [Abstract] [Full Text] [PDF]

				G. C. Faas, H. Adwanikar, R. W. Gereau IV, and P. Saggau Modulation of Presynaptic Calcium Transients by Metabotropic Glutamate Receptor Activation: A Differential Role in Acute Depression of Synaptic Transmission and Long-Term Depression J. Neurosci., August 15, 2002; 22(16): 6885 - 6890. [Abstract] [Full Text] [PDF]

				S. Otani, H. Daniel, M. Takita, and F. Crepel Long-Term Depression Induced by Postsynaptic Group II Metabotropic Glutamate Receptors Linked to Phospholipase C and Intracellular Calcium Rises in Rat Prefrontal Cortex J. Neurosci., May 1, 2002; 22(9): 3434 - 3444. [Abstract] [Full Text] [PDF]

				C. Millan, R. Lujan, R. Shigemoto, and J. Sanchez-Prieto The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects Both [Ca2+]c and cAMP. EVIDENCE FOR A STRONG REDUCTION OF Ca2+ ENTRY IN SINGLE NERVE TERMINALS J. Biol. Chem., April 12, 2002; 277(16): 14092 - 14101. [Abstract] [Full Text] [PDF]

				A. J. Straiker, C. R. Borden, and J. M. Sullivan G-Protein alpha Subunit Isoforms Couple Differentially to Receptors that Mediate Presynaptic Inhibition at Rat Hippocampal Synapses J. Neurosci., April 1, 2002; 22(7): 2460 - 2468. [Abstract] [Full Text] [PDF]

				G. Sansig, T. J. Bushell, V. R. J. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, et al. Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7 J. Neurosci., November 15, 2001; 21(22): 8734 - 8745. [Abstract] [Full Text] [PDF]

				J. Pamidimukkala and M. Hay Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H387 - H395. [Abstract] [Full Text] [PDF]

				D. I. Evans, R. S. G. Jones, and G. Woodhall Differential Actions of PKA and PKC in the Regulation of Glutamate Release by Group III mGluRs in the Entorhinal Cortex J Neurophysiol, February 1, 2001; 85(2): 571 - 579. [Abstract] [Full Text] [PDF]

				N. E. Schwartz and S. Alford Physiological Activation of Presynaptic Metabotropic Glutamate Receptors Increases Intracellular Calcium and Glutamate Release J Neurophysiol, July 1, 2000; 84(1): 415 - 427. [Abstract] [Full Text] [PDF]

				D. I. Evans, R. S. G. Jones, and G. Woodhall Activation of Presynaptic Group III Metabotropic Receptors Enhances Glutamate Release in Rat Entorhinal Cortex J Neurophysiol, May 1, 2000; 83(5): 2519 - 2525. [Abstract] [Full Text] [PDF]

				J. S. Diamond and C. E. Jahr Synaptically Released Glutamate Does Not Overwhelm Transporters on Hippocampal Astrocytes During High-Frequency Stimulation J Neurophysiol, May 1, 2000; 83(5): 2835 - 2843. [Abstract] [Full Text] [PDF]

				S.-C. Chuang, R. Bianchi, and R. K. S. Wong Group I mGluR Activation Turns on a Voltage-Gated Inward Current in Hippocampal Pyramidal Cells J Neurophysiol, May 1, 2000; 83(5): 2844 - 2853. [Abstract] [Full Text] [PDF]

				J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman Synaptic Control of Motoneuronal Excitability Physiol Rev, April 1, 2000; 80(2): 767 - 852. [Abstract] [Full Text] [PDF]

				V. Matveev and X.-J. Wang Implications of All-or-None Synaptic Transmission and Short-Term Depression beyond Vesicle Depletion: A Computational Study J. Neurosci., February 15, 2000; 20(4): 1575 - 1588. [Abstract] [Full Text] [PDF]

				S. Iwasaki, A. Momiyama, O. D. Uchitel, and T. Takahashi Developmental Changes in Calcium Channel Types Mediating Central Synaptic Transmission J. Neurosci., January 1, 2000; 20(1): 59 - 65. [Abstract] [Full Text] [PDF]

				C. Zhang and J. T. Schmidt Adenosine A1 and Class II Metabotropic Glutamate Receptors Mediate Shared Presynaptic Inhibition of Retinotectal Transmission J Neurophysiol, December 1, 1999; 82(6): 2947 - 2955. [Abstract] [Full Text] [PDF]

				N. B. Sawtell, K. M. Huber, J. C. Roder, and M. F. Bear Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors J Neurophysiol, December 1, 1999; 82(6): 3594 - 3597. [Abstract] [Full Text] [PDF]

				X.-W. Dong and J. L. Feldman Distinct Subtypes of Metabotropic Glutamate Receptors Mediate Differential Actions on Excitability of Spinal Respiratory Motoneurons J. Neurosci., July 1, 1999; 19(13): 5173 - 5184. [Abstract] [Full Text] [PDF]

				M. Masugi, M. Yokoi, R. Shigemoto, K. Muguruma, Y. Watanabe, G. Sansig, H. van der Putten, and S. Nakanishi Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Deficit in Fear Response and Conditioned Taste Aversion J. Neurosci., February 1, 1999; 19(3): 955 - 963. [Abstract] [Full Text] [PDF]

				M. Zhuo, J. T. Laitinen, X.-C. Li, and R. D. Hawkins On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus Learn. Mem., January 1, 1999; 6(1): 63 - 76. [Abstract] [Full Text]

				M. Zhuo, J. T. Laitinen, X.-C. Li, and R. D. Hawkins On the Respective Roles of Nitric Oxide and Carbon Monoxide in Long-Term Potentiation in the Hippocampus Learn. Mem., November 1, 1998; 5(6): 467 - 480. [Abstract] [Full Text]

				M. Scanziani, B. H. Gahwiler, and S. Charpak Target cell-specific modulation of transmitter release at terminals from a single axon PNAS, September 29, 1998; 95(20): 12004 - 12009. [Abstract] [Full Text] [PDF]

				T. A. Macek, H. Schaffhauser, and P. J. Conn Protein Kinase C and A3 Adenosine Receptor Activation Inhibit Presynaptic Metabotropic Glutamate Receptor (mGluR) Function and Uncouple mGluRs from GTP-Binding Proteins J. Neurosci., August 15, 1998; 18(16): 6138 - 6146. [Abstract] [Full Text] [PDF]

				Z. Chu and J. J. Hablitz Activation of Group I mGluRs Increases Spontaneous IPSC Frequency in Rat Frontal Cortex J Neurophysiol, August 1, 1998; 80(2): 621 - 627. [Abstract] [Full Text] [PDF]

				M. Hay and E. M. Hasser Measurement of synaptic vesicle exocytosis in aortic baroreceptor neurons Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H710 - H716. [Abstract] [Full Text] [PDF]

				D. H. Sanes, J. McGee, and E. J. Walsh Metabotropic Glutamate Receptor Activation Modulates Sound Level Processing in the Cochlear Nucleus J Neurophysiol, July 1, 1998; 80(1): 209 - 217. [Abstract] [Full Text] [PDF]

				W. Morishita, S. A. Kirov, and B. E. Alger Evidence for Metabotropic Glutamate Receptor Activation in the Induction of Depolarization-Induced Suppression of Inhibition in Hippocampal CA1 J. Neurosci., July 1, 1998; 18(13): 4870 - 4882. [Abstract] [Full Text] [PDF]

				J. Doherty and R. Dingledine Differential Regulation of Synaptic Inputs to Dentate Hilar Border Interneurons by Metabotropic Glutamate Receptors J Neurophysiol, June 1, 1998; 79(6): 2903 - 2910. [Abstract] [Full Text] [PDF]

				G. A. Kinney, P. J. Emmerson, and R. J. Miller Galanin Receptor-Mediated Inhibition of Glutamate Release in the Arcuate Nucleus of the Hypothalamus J. Neurosci., May 15, 1998; 18(10): 3489 - 3500. [Abstract] [Full Text] [PDF]

				M. Levy, J. Jing, D. Chikvashvili, W. B. Thornhill, and I. Lotan Activation of a Metabotropic Glutamate Receptor and Protein Kinase C Reduce the Extent of Inactivation of the K+ Channel Kv1.1/Kvbeta 1.1 via Dephosphorylation of Kv1.1 J. Biol. Chem., March 13, 1998; 273(11): 6495 - 6502. [Abstract] [Full Text] [PDF]

				I. Herrero, M. T. Miras-Portugal, and J. Sanchez-Prieto Functional Switch from Facilitation to Inhibition in the Control of Glutamate Release by Metabotropic Glutamate Receptors J. Biol. Chem., January 23, 1998; 273(4): 1951 - 1958. [Abstract] [Full Text] [PDF]

				K. M. Huber, N. B. Sawtell, and M. F. Bear Effects of the Metabotropic Glutamate Receptor Antagonist MCPG on Phosphoinositide Turnover and Synaptic Plasticity in Visual Cortex J. Neurosci., January 1, 1998; 18(1): 1 - 9. [Abstract] [Full Text] [PDF]

				H. von Gersdorff, R. Schneggenburger, S. Weis, and E. Neher Presynaptic Depression at a Calyx Synapse: The Small Contribution of Metabotropic Glutamate Receptors J. Neurosci., November 1, 1997; 17(21): 8137 - 8146. [Abstract] [Full Text] [PDF]

				E. M. Aronica, J. A. Gorter, M.-C. Paupard, S. Y. Grooms, M. V. L. Bennett, and R. S. Zukin Status Epilepticus-Induced Alterations in Metabotropic Glutamate Receptor Expression in Young and Adult Rats J. Neurosci., November 1, 1997; 17(21): 8588 - 8595. [Abstract] [Full Text] [PDF]

				N. E. Schoppa and G. L. Westbrook Modulation of mEPSCs in Olfactory Bulb Mitral Cells by Metabotropic Glutamate Receptors J Neurophysiol, September 1, 1997; 78(3): 1468 - 1475. [Abstract] [Full Text] [PDF]

				S. C. Molitor and P. B. Manis Evidence for Functional Metabotropic Glutamate Receptors in the Dorsal Cochlear Nucleus J Neurophysiol, April 1, 1997; 77(4): 1889 - 1905. [Abstract] [Full Text] [PDF]

				J. Doherty and R. Dingledine Regulation of Excitatory Input to Inhibitory Interneurons of the Dentate Gyrus During Hypoxia J Neurophysiol, January 1, 1997; 77(1): 393 - 404. [Abstract] [Full Text] [PDF]

				T. Takahashi, I. D. Forsythe, T. Tsujimoto, M. Barnes-Davies, and K. Onodera Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor Science, October 25, 1996; 274(5287): 594 - 597. [Abstract] [Full Text]

				R. Pekhletski, R. Gerlai, L. S. Overstreet, X.-P. Huang, N. Agopyan, N. T. Slater, W. Abramow-Newerly, J. C. Roder, and D. R. Hampson Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor J. Neurosci., October 15, 1996; 16(20): 6364 - 6373. [Abstract] [Full Text] [PDF]

				X.-W. Dong, D. Morin, and J. L. Feldman Multiple Actions of 1S,3R-ACPD in Modulating Endogenous Synaptic Transmission to Spinal Respiratory Motoneurons J. Neurosci., August 15, 1996; 16(16): 4971 - 4982. [Abstract] [Full Text] [PDF]

				G Riedel, W Wetzel, and K G Reymann Metabotropic glutamate receptors in spatial and nonspatial learning in rats studied by means of agonist and antagonist application. Learn. Mem., January 1, 1995; 2(5): 243 - 265. [Abstract] [PDF]