HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kocsis, B Articles by Pasztor, E Search for Related Content PubMed PubMed Citation Articles by Kocsis, B Articles by Pasztor, E

Department of Physiology, National Institute of Neurosurgery, Budapest, Hungary.

1. Sympathetic nerve discharge (SND) of three postganglionic nerves with different functions and anatomical locations was simultaneously recorded at rest and during severe cerebral ischaemia (Cushing reaction). The three nerves, controlling the heart (inferior cardiac nerve), visceral (renal nerve) and skeletal muscle circulation (vertebral nerve), were selected with the assumption that their activity pattern will represent the differential central autonomic command to the major players of the circulatory response to cerebral ischaemia. 2. Changes in the power density spectra of the nerve signals, and in the pairwise coherence functions, elicited by the cerebral ischaemia, were evaluated separately for the rhythmic (R-SND, i.e. between 0 and 6 Hz) and high-frequency (HF-SND, i.e. between 12 and 100 Hz) components of the nerve signals. 3. The sympathetic nerve response to cerebral ischaemia developed in two phases. Phase 1 was a massive R-SND reaction and phase 2 was characterized by SND desynchronization and by the emergence of HF-SND. The power of HF-SND occupied a wide band between 12 and 80 Hz with maximum between 20 and 30 Hz. All three nerves were involved in the Cushing response but the magnitude and character of the reactions were specific for each nerve. In the cardiac nerve, the power of the rhythmic component of the discharge increased almost twice the control and remained dominant during the whole reaction, strongly modulating HF-SND during the second phase. In the vasomotor nerves, R-SND was suppressed during phase 2 and HF-SND occupied 65% of the total power of the signal. Near equal R- to HF-SND proportions, however, were reached on different activity levels in renal and vertebral nerves. Whereas total renal SND did not change, the power of the vertebral SND increased more than twice. In addition, desynchronization in the vertebral SND was preceded by a massive R-SND reaction during phase 1, which was missing in the renal nerve. 4. For all possible nerve pairs, R-SND was highly coherent before the reaction and remained so during intracranial pressure elevation, regardless of the direction and magnitude of the changes in absolute and/or relative power of this component in different nerves. On the other hand, HF-SND never correlated between any of the nerve pairs indicating that this component in each nerve originated from specific sources of regional sympathetic activity.(ABSTRACT TRUNCATED AT 400 WORDS)

This article has been cited by other articles:

				M. J. Kenney, F. Blecha, R. J. Fels, and D. A. Morgan Altered frequency responses of sympathetic nerve discharge bursts after IL-1beta and mild hypothermia J Appl Physiol, July 1, 2002; 93(1): 280 - 288. [Abstract] [Full Text] [PDF]

				L. J. Badra, W. H. Cooke, J. B. Hoag, A. A. Crossman, T. A. Kuusela, K. U. O. Tahvanainen, and D. L. Eckberg Respiratory modulation of human autonomic rhythms Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2674 - H2688. [Abstract] [Full Text] [PDF]

				M. J. Kenney, D. E. Claassen, R. J. Fels, and C. S. Saindon Cold stress alters characteristics of sympathetic nerve discharge bursts J Appl Physiol, August 1, 1999; 87(2): 732 - 742. [Abstract] [Full Text] [PDF]

				R. J. Gurrera Sympathoadrenal Hyperactivity and the Etiology of Neuroleptic Malignant Syndrome Am J Psychiatry, February 1, 1999; 156(2): 169 - 180. [Abstract] [Full Text]

				M. J. Kenney, D. E. Claassen, M. R. Bishop, and R. J. Fels Regulation of the sympathetic nerve discharge bursting pattern during heat stress Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1992 - R2001. [Abstract] [Full Text] [PDF]

				B. Kocsis and K. Gyimesi-Pelczer Spinal segments communicating resting sympathetic activity to postganglionic nerves of the stellate ganglion Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R400 - R409. [Abstract] [Full Text] [PDF]

				D. E. Claassen, R. J. Fels, and M. J. Kenney Altered frequency characteristics of sympathetic nerve activity after sustained elevation in arterial pressure Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R694 - R703. [Abstract] [Full Text] [PDF]