HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marshall, J M Articles by Turner, L Search for Related Content PubMed PubMed Citation Articles by Marshall, J M Articles by Turner, L

Department of Physiology, Medical School, Birmingham.

1. In anaesthetized rats, systemic hypoxia evoked hyperventilation, tachycardia, a fall in arterial pressure, vasodilatation in skeletal muscle and increases in K+ concentration measured in arterial plasma ([K+]a), venous efflux from muscle ([K+]v) and in right atrial plasma ([K+]at). The ATP-sensitive potassium (K+ATP) channel inhibitor glibenclamide (10 or 20 mg kg-1 i.v.) reduced the muscle vasodilatation and increase in [K+]v, but had no significant effect on the other changes. 2. The adenosine receptor antagonist, 8-phenyltheophylline (8-PT, 10 mg kg-1 i.v.) had similar effects to glibenclamide. 3. Glibenclamide reduced the muscle vasodilatation evoked by the adenosine analogue, 2-chloroadenosine given i.v. (30 micrograms kg-1). 4. Infusion of adenosine (0.3 mg kg-1 min-1 for 5 min) into the hindlimb evoked muscle vasodilatation and an increase in [K+]v, both of which were abolished by 8-PT. 5. We propose that during systemic hypoxia, part of the muscle vasodilatation that can be attributed to adenosine is due to the action of K+, which is released from skeletal muscle fibres through glibenclamide-sensitive K+ channels (possibly K+ATP channels) that are activated by adenosine. This may be a general mechanism for the vasodilator influence of adenosine.

This article has been cited by other articles:

				A. M. Coney and J. M. Marshall Contribution of {alpha}2-adrenoceptors and Y1 neuropeptide Y receptors to the blunting of sympathetic vasoconstriction induced by systemic hypoxia in the rat J. Physiol., August 1, 2007; 582(3): 1349 - 1359. [Abstract] [Full Text] [PDF]

				J. M. Quayle, M. R. Turner, H. E. Burrell, and T. Kamishima Effects of hypoxia, anoxia, and metabolic inhibitors on KATP channels in rat femoral artery myocytes Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H71 - H80. [Abstract] [Full Text] [PDF]

				C. J. Ray and J. M. Marshall The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium J. Physiol., January 1, 2006; 570(1): 85 - 96. [Abstract] [Full Text] [PDF]

				P.-Y. Cheung, K. J. Barrington, and D. L. Bigam Temporal effects of prolonged hypoxaemia and reoxygenation on systemic, pulmonary and mesenteric perfusion in newborn piglets Cardiovasc Res, August 1, 1998; 39(2): 451 - 458. [Abstract] [Full Text] [PDF]

				L. Zhang and D. Xiao Effects of chronic hypoxia on Ca2+ mobilization and Ca2+ sensitivity of myofilaments in uterine arteries Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H132 - H138. [Abstract] [Full Text] [PDF]

				B. C. Sheridan, R. C. McIntyre Jr., D. R. Meldrum, and D. A. Fullerton KATP channels contribute to beta - and adenosine receptor-mediated pulmonary vasorelaxation Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L950 - L956. [Abstract] [Full Text] [PDF]