HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kotecha, N Articles by Neild, T O Search for Related Content PubMed PubMed Citation Articles by Kotecha, N Articles by Neild, T O

Department of Physiology, Monash University, Clayton, Victoria, Australia.

1. Dilatation of arterioles isolated from the guinea-pig small intestine was evoked by stimulation of a submucous ganglion and the application of acetylcholine, vasoactive intestinal peptide, galanin or dynorphin A. Changes in arteriole diameter and smooth muscle membrane potential were recorded simultaneously. 2. Ganglion stimulation caused vasodilatation and smooth muscle hyperpolarization that varied in both amplitude and time course from one arteriole to another. Vasodilatation could occur without hyperpolarization. 3. Vasodilatation caused by acetylcholine was accompanied by a rapidly developing hyperpolarization that began to decline before the maximum vasodilator effect had developed. 4. Vasoactive intestinal peptide caused dilatation without any change in smooth muscle membrane potential. 5. Galanin and dynorphin caused dilatation and a hyperpolarization of similar time course to the dilatation. 6. In 48% of arterioles tested the dilatation appeared to be mediated solely by acetylcholine. In 31% there was a cholinergic component, but no evidence for the involvement of acetylcholine in the remaining 21%. When the non-cholinergic dilatation occurred without a hyperpolarization we conclude that it was due to vasoactive intestinal peptide; otherwise it may have been due to either galanin or dynorphin.

This article has been cited by other articles:

				K. Goto, K. Fujii, I. Abe, and M. Fujishima Sympathetic Control of Arterial Membrane Potential by ATP-Sensitive K+-Channels Hypertension, January 1, 2000; 35(1): 379 - 384. [Abstract] [Full Text] [PDF]

				N. Kotecha and F. P. Coffa NO mediates postjunctional inhibitory effect of neurogenic ACh in guinea pig small intestinal microcirculation Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1441 - H1446. [Abstract] [Full Text] [PDF]

				J. Kagstrom, C. Olsson, M. Axelsson, and C. E. Franklin Peptidergic control of gastrointestinal blood flow in the estuarine crocodile, Crocodylus porosus Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1740 - R1750. [Abstract] [Full Text] [PDF]

				S. A. Ahtaridis, S. S. Katoch, and R. S. Moreland Mechanism of galanin-induced contraction of longitudinal smooth muscle of the rat jejunum Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G306 - G313. [Abstract] [Full Text] [PDF]

				M. Szentivanyi Jr, V. Berczi, T. Huttl, R. S. Reneman, and E. Monos Venous Myogenic Tone and Its Regulation Through K+ Channels Depends on Chronic Intravascular Pressure Circ. Res., December 19, 1997; 81(6): 988 - 995. [Abstract] [Full Text]

				R. D. Bukoski, K. Bian, Y. Wang, and M. Mupanomunda Perivascular Sensory Nerve Ca2+ Receptor and Ca2+-Induced Relaxation of Isolated Arteries Hypertension, December 1, 1997; 30(6): 1431 - 1439. [Abstract] [Full Text]

				R. Haberberger, M. Schemann, H. Sann, and W. Kummer Innervation pattern of guinea pig pulmonary vasculature depends on vascular diameter J Appl Physiol, February 1, 1997; 82(2): 426 - 434. [Abstract] [Full Text] [PDF]