HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ikeda, S R Articles by Korn, S J Search for Related Content PubMed PubMed Citation Articles by Ikeda, S R Articles by Korn, S J

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912, USA.

1. Block by external tetraethylammonium (TEA) was examined on currents carried by potassium (K+) and sodium (Na+) through the cloned delayed rectifier K+ channel Kv2.1. 2. In the presence of high intracellular K+ and high extracellular Na+, currents through the Kv2.1 channel were carried almost exclusively by K+. In the absence of both intracellular and extracellular K+, large currents were carried by Na+ through the Kv2.1 channel. 3. External application of 30 mM TEA blocked K+ currents through Kv2.1 by 87%. The same external concentration of TEA had no effect on Na+ currents through this channel. 4. As the K+ concentration was increased between 0 and 140 mM, the percentage of current blocked by TEA progressively increased from 0 to 87%. 5. These data indicate that block of K+ channels by external TEA depends on the permeating ion. Furthermore, these data indicate that in the presence of Na+ and absence of K+, TEA does not bind to the channel, and that addition of low concentrations of K+ facilitates TEA binding.

This article has been cited by other articles:

				M. Hoyles, V. Krishnamurthy, M. Siksik, and S.-H. Chung Brownian Dynamics Theory for Predicting Internal and External Blockages of Tetraethylammonium in the KcsA Potassium Channel Biophys. J., January 15, 2008; 94(2): 366 - 378. [Abstract] [Full Text] [PDF]

				C. A. Ahern, A. L. Eastwood, H. A. Lester, D. A. Dougherty, and R. Horn A Cation-{pi} Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels J. Gen. Physiol., December 1, 2006; 128(6): 649 - 657. [Abstract] [Full Text] [PDF]

				H. T Kurata, K. W Doerksen, J. R Eldstrom, S. Rezazadeh, and D. Fedida Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels J. Physiol., October 1, 2005; 568(1): 31 - 46. [Abstract] [Full Text] [PDF]

				Y.-C. Yang and C.-C. Kuo An Inactivation Stabilizer of the Na+ Channel Acts as an Opportunistic Pore Blocker Modulated by External Na+ J. Gen. Physiol., April 25, 2005; 125(5): 465 - 481. [Abstract] [Full Text] [PDF]

				J. F. Consiglio and S. J. Korn Influence of Permeant Ions on Voltage Sensor Function in the Kv2.1 Potassium Channel J. Gen. Physiol., March 29, 2004; 123(4): 387 - 400. [Abstract] [Full Text] [PDF]

				F. Gomez-Lagunas, C. V.F. Batista, T. Olamendi-Portugal, M. E. Ramirez-Dominguez, and L. D. Possani Inhibition of the Collapse of the Shaker K+ Conductance by Specific Scorpion Toxins J. Gen. Physiol., February 23, 2004; 123(3): 265 - 279. [Abstract] [Full Text] [PDF]

				D. Kerschensteiner, F. Monje, and M. Stocker Structural Determinants of the Regulation of the Voltage-gated Potassium Channel Kv2.1 by the Modulatory alpha -Subunit Kv9.3 J. Biol. Chem., May 9, 2003; 278(20): 18154 - 18161. [Abstract] [Full Text] [PDF]

				S. Lin, Z. Wang, and D. Fedida Influence of permeating ions on Kv1.5 channel block by nifedipine Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1160 - H1172. [Abstract] [Full Text] [PDF]