| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology, Royal Free Hospital School of Medicine, London, UK.
1. In anaesthetized, paralysed and artificially ventilated cats, recordings have been made in the nucleus tractus solitarii (NTS) to assess further the role of this nucleus in mediating the cardiorespiratory responses that are elicited on stimulation within the hypothalamic defence area (HDA). 2. The responses of NTS neurones to stimulation in the hypothalamus were assessed, as were their patterns of evoked response to electrical stimulation of the sinus (SN), aortic (AN), superior laryngeal (SLN) and vagus (VN) nerves. 3. Stimulation in the HDA affected the activity of 110 NTS neurones (85 studied in intracellular and 25 studied in extracellular recordings). The present study focused on those sixty-eight neurones that were excited by such stimulation (51 intracellular recordings and 17 extracellular recordings). 4. Of the sixty-eight neurones that were excited by HDA stimulation, seven revealed no changes in membrane potential or evoked discharge (2 neurones) but the stimulus facilitated the excitatory effects of stimulating either (or both) the SN and SLN. An additional group of neurones showed powerful excitatory responses to HDA stimulation (15 studied with extracellular and 35 with intracellular recording). Evoked EPSPs had onset latencies in the range of 1-30 ms. Of those thirty-five neurones displaying EPSPs, twenty-six were shown to receive convergent inputs on nerve stimulation. In nine neurones the early EPSP in response to HDA stimulation was followed by an IPSP. 5. In a further group of neurones HDA stimulation elicited a long-lasting IPSP, but this was not analysed further because its features have been described in detail in earlier studies from this laboratory. 6. The patterns of response of several neurones excited by stimulation in the HDA are consistent with them forming a group of NTS interneurones that mediate the hypothalamically evoked cardiovascular responses, including modulation of reflex function, which is a major feature of cardiorespiratory control. This possibility is discussed in the light of the present physiological observations and descriptions of an intrinsic NTS group of GABA-containing neurones that have been suggested to fulfil such a role.
This article has been cited by other articles:
|
|
 |
|
  S.-i. Sekizawa and A. C. Bonham Group I Metabotropic Glutamate Receptors on Second-Order Baroreceptor Neurons Are Tonically Activated and Induce a Na+-Ca2+ Exchange Current J Neurophysiol, February 1, 2006; 95(2): 882 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Mousa, L. Gao, K. G. Cornish, and I. H. Zucker Effects of angiotensin II on autonomic components of nasopharyngeal stimulation in male conscious rabbits J Appl Physiol, May 1, 2005; 98(5): 1607 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, X.-F. Liu, K. G. Cornish, I. H. Zucker, and K. P. Patel Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H205 - H213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Mercer and J. G. Hildebrand Developmental Changes in the Density of Ionic Currents in Antennal-Lobe Neurons of the Sphinx Moth, Manduca sexta J Neurophysiol, June 1, 2002; 87(6): 2664 - 2675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Page and L. A. Blackshaw GABAB Receptors Inhibit Mechanosensitivity of Primary Afferent Endings J. Neurosci., October 1, 1999; 19(19): 8597 - 8602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Haibara, L. G. H. Bonagamba, and B. H. Machado Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R69 - R80. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
