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Physiologie Institüt II, Heinrich-Heine-Universität, Düsseldorf, Germany. Stevensd@uni-duesseldorf.de

1. Intracellular recordings from histaminergic neurons of the tuberomammillary (TM) nucleus reveal subthreshold depolarizing potentials (DPs) which persist in the presence of tetrodotoxin. 2. Block of hyperpolarization-activated current by 1-4 mM Cs+ failed to reduce spontaneous activity or DPs. 3. In the presence of tetrodotoxin DPs are voltage dependent and are depressed by Cd2+ and Co2+. 4. Ba2+ (100 microM) treatment enhances DP amplitude and converts low-amplitude potentials to tetrodotoxin-insensitive action potentials. 5. In the presence of TTX, DPs are reduced by Ni2+. Spontaneous action potentials are also reduced by Ni2+ (100-300 microM). A low-threshold Ca2+ current is present which is sensitive to Ni2+. These results indicate the presence of calcium currents, perhaps of the low-threshold type, which contribute to activation of action potentials in TM neurons.

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