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Inhibition of effects of flow on potassium permeability in single perfused frog mesenteric capillaries

M. Kajimura and C. C. Michel

We have investigated the effects of various potential inhibitors on flow-dependent K⁺ permeability (P_K) of single perfused mesenteric microvessels in pithed frogs.

Neither superfusion with a nitric oxide synthase inhibitor, N^G-monomethyl-L-arginine (10 or 100 µmol l^-1), nor the addition of indomethacin (30 µmol l^-1) to both perfusate and superfusate reduced the positive correlation between P_K and flow velocity (U).

In the presence of agents known to raise intracellular levels of adenosine 3',5'-cyclic monophosphate (noradrenaline, 8-bromo-cAMP and a combination of forskolin and rolipram) the slope of the relation between P_K and U was no longer significant, so that P_K was no longer flow dependent.

These results confirm that the flow dependence of P_K is a biological process and not an artefact of measurement and suggest a role for intracellular cAMP rather than nitric oxide or prostacyclin in the flow-dependent modulation of P_K in frog mesenteric microvessels.

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