| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1G subunit by 2
subunits
The modulatory action of the 2 subunit on various high-voltage-activated calcium channels has been demonstrated previously. However, very little is known about auxiliary subunit modulation of low-voltage-activated (LVA) calcium channels. We have examined the modulation of the 1G subunit corresponding to the neuronal T-type calcium channel by the ubiquitously expressed 2-1 and brain-specific 2-3 subunits.
The 1G subunit was expressed alone or in combination with either the 2-1 or 2-3 subunit in human embryonic kidney (HEK 293) cells and whole-cell barium currents were measured. The current density-voltage relationships for peak and sustained current, kinetics of current activation and inactivation, voltage dependence of current inactivation and time course of the recovery from inactivation were analysed for each type of expressed channel. No significant difference was found for any of the examined parameters.
These results suggest that the LVA 1G channel is not regulated by known auxiliary 2 subunits.
This article has been cited by other articles:
|
|
 |
|
  S. J. Dubel, C. Altier, S. Chaumont, P. Lory, E. Bourinet, and J. Nargeot Plasma Membrane Expression of T-type Calcium Channel {alpha}1 Subunits Is Modulated by High Voltage-activated Auxiliary Subunits J. Biol. Chem., July 9, 2004; 279(28): 29263 - 29269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, L. Stevens, N. Klugbauer, and D. Wray Roles of Molecular Regions in Determining Differences between Voltage Dependence of Activation of CaV3.1 and CaV1.2 Calcium Channels J. Biol. Chem., June 25, 2004; 279(26): 26858 - 26867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Finlin, S. M. Crump, J. Satin, and D. A. Andres Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases PNAS, November 25, 2003; 100(24): 14469 - 14474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Perez-Reyes Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels Physiol Rev, January 1, 2003; 83(1): 117 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Qin, S. Yagel, M.-L. Momplaisir, E. E. Codd, and M. R. D'Andrea Molecular Cloning and Characterization of the Human Voltage-Gated Calcium Channel alpha 2delta -4 Subunit Mol. Pharmacol., September 1, 2002; 62(3): 485 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Michels, J. Matthes, R. Handrock, U. Kuchinke, F. Groner, L. L. Cribbs, A. Pereverzev, T. Schneider, E. Perez-Reyes, and S. Herzig Single-Channel Pharmacology of Mibefradil in Human Native T-Type and Recombinant Cav3.2 Calcium Channels Mol. Pharmacol., March 1, 2002; 61(3): 682 - 694. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
