HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Feldmeyer, D. Articles by Sakmann, B. Search for Related Content PubMed PubMed Citation Articles by Feldmeyer, D. Articles by Sakmann, B. Related Collections Review articles

Synaptic efficacy and reliability of excitatory connections between the principal neurones of the input (layer 4) and output layer (layer 5) of the neocortex

Dirk Feldmeyer and Bert Sakmann

A prerequisite for the understanding of how a cortical column functions is a description of small and defined neuronal circuits consisting of only a few identified neurones. Here we summarise, with particular reference to the barrel cortex, the morphological and physiological properties of two synaptic connections, namely those between pairs of spiny neurones in layer 4 and pairs of pyramidal cells in layer 5. While layer 4 spiny neurones are the cortical input neurones that amplify and relay incoming excitation from the periphery, layer 5 pyramidal cells integrate neuronal activity both within and across cortical columns and subsequently distribute it to both cortical and subcortical brain regions.

This article has been cited by other articles:

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				S. M. Sunkin and J. G. Hohmann Insights from spatially mapped gene expression in the mouse brain Hum. Mol. Genet., October 15, 2007; 16(R2): R209 - R219. [Abstract] [Full Text] [PDF]

				G. T. Einevoll, K. H. Pettersen, A. Devor, I. Ulbert, E. Halgren, and A. M. Dale Laminar Population Analysis: Estimating Firing Rates and Evoked Synaptic Activity From Multielectrode Recordings in Rat Barrel Cortex J Neurophysiol, March 1, 2007; 97(3): 2174 - 2190. [Abstract] [Full Text] [PDF]

				W. van Drongelen, H. Koch, F. P. Elsen, H. C. Lee, A. Mrejeru, E. Doren, C. J. Marcuccilli, M. Hereld, R. L. Stevens, and J.-M. Ramirez Role of Persistent Sodium Current in Bursting Activity of Mouse Neocortical Networks In Vitro J Neurophysiol, November 1, 2006; 96(5): 2564 - 2577. [Abstract] [Full Text] [PDF]

				D. Feldmeyer, J. Lubke, and B. Sakmann Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats J. Physiol., September 1, 2006; 575(2): 583 - 602. [Abstract] [Full Text] [PDF]

				J.-V. Le Be and H. Markram From the Cover: Spontaneous and evoked synaptic rewiring in the neonatal neocortex PNAS, August 29, 2006; 103(35): 13214 - 13219. [Abstract] [Full Text] [PDF]

				M. Morishima and Y. Kawaguchi Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex. J. Neurosci., April 19, 2006; 26(16): 4394 - 4405. [Abstract] [Full Text] [PDF]

				F. J Veredas, F. J Vico, and J.-M. Alonso Factors determining the precision of the correlated firing generated by a monosynaptic connection in the cat visual pathway J. Physiol., September 15, 2005; 567(3): 1057 - 1078. [Abstract] [Full Text] [PDF]

				E. E. Kwegyir-Afful, R. M. Bruno, D. J. Simons, and A. Keller The Role of Thalamic Inputs in Surround Receptive Fields of Barrel Neurons J. Neurosci., June 22, 2005; 25(25): 5926 - 5934. [Abstract] [Full Text] [PDF]

				R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232. [Abstract] [Full Text] [PDF]

				A. I. Cowan and C. Stricker Functional Connectivity in Layer IV Local Excitatory Circuits of Rat Somatosensory Cortex J Neurophysiol, October 1, 2004; 92(4): 2137 - 2150. [Abstract] [Full Text] [PDF]

				L. Venance, J. Glowinski, and C. Giaume Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slices J. Physiol., August 15, 2004; 559(1): 215 - 230. [Abstract] [Full Text] [PDF]

				J.-C. Beique, E. M. Chapin-Penick, L. Mladenovic, and R. Andrade Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex J. Physiol., May 1, 2004; 556(3): 739 - 754. [Abstract] [Full Text] [PDF]

				T. Nevian and B. Sakmann Single Spine Ca2+ Signals Evoked by Coincident EPSPs and Backpropagating Action Potentials in Spiny Stellate Cells of Layer 4 in the Juvenile Rat Somatosensory Barrel Cortex J. Neurosci., February 18, 2004; 24(7): 1689 - 1699. [Abstract] [Full Text] [PDF]

				D. Schubert, R. Kotter, K. Zilles, H. J. Luhmann, and J. F. Staiger Cell Type-Specific Circuits of Cortical Layer IV Spiny Neurons J. Neurosci., April 1, 2003; 23(7): 2961 - 2970. [Abstract] [Full Text] [PDF]

				J. A. Hirsch Synaptic Physiology and Receptive Field Structure in the Early Visual Pathway of the Cat Cereb Cortex, January 1, 2003; 13(1): 63 - 69. [Abstract] [Full Text] [PDF]

				Q. Li, S. Clark, D. V. Lewis, and W. A. Wilson NMDA Receptor Antagonists Disinhibit Rat Posterior Cingulate and Retrosplenial Cortices: A Potential Mechanism of Neurotoxicity J. Neurosci., April 15, 2002; 22(8): 3070 - 3080. [Abstract] [Full Text] [PDF]

				J. Qian and J. L. Noebels Presynaptic Ca2+ Channels and Neurotransmitter Release at the Terminal of a Mouse Cortical Neuron J. Neurosci., June 1, 2001; 21(11): 3721 - 3728. [Abstract] [Full Text] [PDF]