HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnston, D. Articles by Migliore, M. Search for Related Content PubMed PubMed Citation Articles by Johnston, D. Articles by Migliore, M. Related Collections Review articles

Dendritic potassium channels in hippocampal pyramidal neurons

Daniel Johnston, Dax A. Hoffman, Jeffrey C. Magee, Nicholas P. Poolos, Shigeo Watanabe, Costa M. Colbert and Michele Migliore

Potassium channels located in the dendrites of hippocampal CA1 pyramidal neurons control the shape and amplitude of back-propagating action potentials, the amplitude of excitatory postsynaptic potentials and dendritic excitability. Non-uniform gradients in the distribution of potassium channels in the dendrites make the dendritic electrical properties markedly different from those found in the soma. For example, the influence of a fast, calcium-dependent potassium current on action potential repolarization is progressively reduced in the first 150 µm of the apical dendrites, so that action potentials recorded farther than 200 µm from the soma have no fast after-hyperpolarization and are wider than those in the soma. The peak amplitude of back-propagating action potentials is also progressively reduced in the dendrites because of the increasing density of a transient potassium channel with distance from the soma. The activation of this channel can be reduced by the activity of a number of protein kinases as well as by prior depolarization. The depolarization from excitatory postsynaptic potentials (EPSPs) can inactivate these A-type K⁺ channels and thus lead to an increase in the amplitude of dendritic action potentials, provided the EPSP and the action potentials occur within the appropriate time window. This time window could be in the order of 15 ms and may play a role in long-term potentiation induced by pairing EPSPs and back-propagating action potentials.

This article has been cited by other articles:

				N. Chen, X. Chen, and J.-H. Wang Homeostasis established by coordination of subcellular compartment plasticity improves spike encoding J. Cell Sci., September 1, 2008; 121(17): 2961 - 2971. [Abstract] [Full Text] [PDF]

				G. Gradwohl and Y. Grossman Analysis of the interaction between the dendritic conductance density and activated area in modulating alpha-motoneuron EPSP: statistical computer model. Neural Comput., June 1, 2008; 20(6): 1385 - 1410. [Abstract] [Full Text] [PDF]

				J. Kim and D. A. Hoffman Potassium Channels: Newly Found Players in Synaptic Plasticity Neuroscientist, June 1, 2008; 14(3): 276 - 286. [Abstract] [PDF]

				Y. Amarillo, J. A. De Santiago-Castillo, K. Dougherty, J. Maffie, E. Kwon, M. Covarrubias, and B. Rudy Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons J. Physiol., April 15, 2008; 586(8): 2093 - 2106. [Abstract] [Full Text] [PDF]

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				B. L. Bloodgood and B. L. Sabatini Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels J. Physiol., March 15, 2008; 586(6): 1475 - 1480. [Abstract] [Full Text] [PDF]

				Myoung Kyu Park, Yu Mi Choi, Yun Kyung Kang, and O. H. Petersen The Endoplasmic Reticulum as an Integrator of Multiple Dendritic Events Neuroscientist, February 1, 2008; 14(1): 68 - 77. [Abstract] [PDF]

				A. M. Hagenston, J. S. Fitzpatrick, and M. F. Yeckel MGluR-Mediated Calcium Waves that Invade the Soma Regulate Firing in Layer V Medial Prefrontal Cortical Pyramidal Neurons Cereb Cortex, February 1, 2008; 18(2): 407 - 423. [Abstract] [Full Text] [PDF]

				R. Yamamoto, Y. Ueta, and N. Kato Dopamine Induces a Slow Afterdepolarization in Lateral Amygdala Neurons J Neurophysiol, August 1, 2007; 98(2): 984 - 992. [Abstract] [Full Text] [PDF]

				D. Fernandez de Sevilla, M. Fuenzalida, A. B. Porto Pazos, and W. Buno Selective Shunting of the NMDA EPSP Component by the Slow Afterhyperpolarization in Rat CA1 Pyramidal Neurons J Neurophysiol, May 1, 2007; 97(5): 3242 - 3255. [Abstract] [Full Text] [PDF]

				N. Gu, K. Vervaeke, and J. F. Storm BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells J. Physiol., May 1, 2007; 580(3): 859 - 882. [Abstract] [Full Text] [PDF]

				L. J. Gentet and S. R. Williams Dopamine Gates Action Potential Backpropagation in Midbrain Dopaminergic Neurons J. Neurosci., February 21, 2007; 27(8): 1892 - 1901. [Abstract] [Full Text] [PDF]

				U. Gordon, A. Polsky, and J. Schiller Plasticity Compartments in Basal Dendrites of Neocortical Pyramidal Neurons J. Neurosci., December 6, 2006; 26(49): 12717 - 12726. [Abstract] [Full Text] [PDF]

				X. Chen, L.-L. Yuan, C. Zhao, S. G. Birnbaum, A. Frick, W. E. Jung, T. L. Schwarz, J. D. Sweatt, and D. Johnston Deletion of Kv4.2 Gene Eliminates Dendritic A-Type K+ Current and Enhances Induction of Long-Term Potentiation in Hippocampal CA1 Pyramidal Neurons. J. Neurosci., November 22, 2006; 26(47): 12143 - 12151. [Abstract] [Full Text] [PDF]

				C. M. Norris, E. M. Blalock, O. Thibault, L. D. Brewer, G. V. Clodfelter, N. M. Porter, and P. W. Landfield Electrophysiological Mechanisms of Delayed Excitotoxicity: Positive Feedback Loop Between NMDA Receptor Current and Depolarization-Mediated Glutamate Release J Neurophysiol, November 1, 2006; 96(5): 2488 - 2500. [Abstract] [Full Text] [PDF]

				W. Han, S. Nattel, T. Noguchi, and A. Shrier C-terminal Domain of Kv4.2 and Associated KChIP2 Interactions Regulate Functional Expression and Gating of Kv4.2 J. Biol. Chem., September 15, 2006; 281(37): 27134 - 27144. [Abstract] [Full Text] [PDF]

				C. Yue and Y. Yaari Axo-Somatic and Apical Dendritic Kv7/M Channels Differentially Regulate the Intrinsic Excitability of Adult Rat CA1 Pyramidal Cells J Neurophysiol, June 1, 2006; 95(6): 3480 - 3495. [Abstract] [Full Text] [PDF]

				K. A. Kleopa, L. B. Elman, B. Lang, A. Vincent, and S. S. Scherer Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations Brain, June 1, 2006; 129(6): 1570 - 1584. [Abstract] [Full Text] [PDF]

				H. H Jerng, K. Kunjilwar, and P. J Pfaffinger Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties J. Physiol., November 1, 2005; 568(3): 767 - 788. [Abstract] [Full Text] [PDF]

				E. Zagha, A. Ozaita, S. Y. Chang, M. S. Nadal, U. Lin, M. J. Saganich, T. McCormack, K. O. Akinsanya, S. Y. Qi, and B. Rudy DPP10 Modulates Kv4-mediated A-type Potassium Channels J. Biol. Chem., May 13, 2005; 280(19): 18853 - 18861. [Abstract] [Full Text] [PDF]

				H. H. Jerng, Y. Qian, and P. J. Pfaffinger Modulation of Kv4.2 Channel Expression and Gating by Dipeptidyl Peptidase 10 (DPP10) Biophys. J., October 1, 2004; 87(4): 2380 - 2396. [Abstract] [Full Text] [PDF]

				I. G. Davison, J. D. Boyd, and K. R. Delaney Dopamine Inhibits Mitral/Tufted-> Granule Cell Synapses in the Frog Olfactory Bulb J. Neurosci., September 15, 2004; 24(37): 8057 - 8067. [Abstract] [Full Text] [PDF]

				K. J. Rhodes, K. I. Carroll, M. A. Sung, L. C. Doliveira, M. M. Monaghan, S. L. Burke, B. W. Strassle, L. Buchwalder, M. Menegola, J. Cao, et al. KChIPs and Kv4 {alpha} Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain J. Neurosci., September 8, 2004; 24(36): 7903 - 7915. [Abstract] [Full Text] [PDF]

				C. Bernard, A. Anderson, A. Becker, N. P. Poolos, H. Beck, and D. Johnston Acquired Dendritic Channelopathy in Temporal Lobe Epilepsy Science, July 23, 2004; 305(5683): 532 - 535. [Abstract] [Full Text] [PDF]

				F. R. Fernandez, E. Morales, A. J. Rashid, R. J. Dunn, and R. W. Turner Inactivation of Kv3.3 Potassium Channels in Heterologous Expression Systems J. Biol. Chem., October 17, 2003; 278(42): 40890 - 40898. [Abstract] [Full Text] [PDF]

				C. Lilliehook, O. Bozdagi, J. Yao, M. Gomez-Ramirez, N. F. Zaidi, W. Wasco, S. Gandy, A. C. Santucci, V. Haroutunian, G. W. Huntley, et al. Altered A{beta} Formation and Long-Term Potentiation in a Calsenilin Knock-Out J. Neurosci., October 8, 2003; 23(27): 9097 - 9106. [Abstract] [Full Text] [PDF]

				M. M. Oh, A. G. Kuo, W. W. Wu, E. A. Sametsky, and J. F. Disterhoft Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons J Neurophysiol, October 1, 2003; 90(4): 2171 - 2179. [Abstract] [Full Text] [PDF]

				A. Jeromin, L.-L. Yuan, A. Frick, P. Pfaffinger, and D. Johnston A Modified Sindbis Vector for Prolonged Gene Expression in Neurons J Neurophysiol, October 1, 2003; 90(4): 2741 - 2745. [Abstract] [Full Text] [PDF]

				R. Shibata, H. Misonou, C. R. Campomanes, A. E. Anderson, L. A. Schrader, L. C. Doliveira, K. I. Carroll, J. D. Sweatt, K. J. Rhodes, and J. S. Trimmer A Fundamental Role for KChIPs in Determining the Molecular Properties and Trafficking of Kv4.2 Potassium Channels J. Biol. Chem., September 19, 2003; 278(38): 36445 - 36454. [Abstract] [Full Text] [PDF]

				C. Bernard and D. Johnston Distance-Dependent Modifiable Threshold for Action Potential Back-Propagation in Hippocampal Dendrites J Neurophysiol, September 1, 2003; 90(3): 1807 - 1816. [Abstract] [Full Text] [PDF]

				M. Martina, G. L. Yao, and B. P. Bean Properties and Functional Role of Voltage-Dependent Potassium Channels in Dendrites of Rat Cerebellar Purkinje Neurons J. Neurosci., July 2, 2003; 23(13): 5698 - 5707. [Abstract] [Full Text] [PDF]

				L. M. Boland, M. Jiang, S. Y. Lee, S. C. Fahrenkrug, M. T. Harnett, and S. M. O'Grady Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels Am J Physiol Cell Physiol, July 1, 2003; 285(1): C161 - C170. [Abstract] [Full Text] [PDF]

				D. Kerschensteiner, F. Monje, and M. Stocker Structural Determinants of the Regulation of the Voltage-gated Potassium Channel Kv2.1 by the Modulatory alpha -Subunit Kv9.3 J. Biol. Chem., May 9, 2003; 278(20): 18154 - 18161. [Abstract] [Full Text] [PDF]

				M. Womack and K. Khodakhah Active Contribution of Dendrites to the Tonic and Trimodal Patterns of Activity in Cerebellar Purkinje Neurons J. Neurosci., December 15, 2002; 22(24): 10603 - 10612. [Abstract] [Full Text] [PDF]

				Y. Schiller Inter-Ictal- and Ictal-Like Epileptic Discharges in the Dendritic Tree of Neocortical Pyramidal Neurons J Neurophysiol, December 1, 2002; 88(6): 2954 - 2962. [Abstract] [Full Text] [PDF]

				D. Tsay and R. Yuste Role of Dendritic Spines in Action Potential Backpropagation: A Numerical Simulation Study J Neurophysiol, November 1, 2002; 88(5): 2834 - 2845. [Abstract] [Full Text] [PDF]

				G. M. J. Ramakers and J. F. Storm A postsynaptic transient K+ current modulated by arachidonic acid regulates synaptic integration and threshold for LTP induction in hippocampal pyramidal cells PNAS, July 23, 2002; 99(15): 10144 - 10149. [Abstract] [Full Text] [PDF]

				L. Cangiano, P. Wallen, and S. Grillner Role of Apamin-Sensitive KCa Channels for Reticulospinal Synaptic Transmission to Motoneuron and for the Afterhyperpolarization J Neurophysiol, July 1, 2002; 88(1): 289 - 299. [Abstract] [Full Text] [PDF]

				S. Watanabe, D. A. Hoffman, M. Migliore, and D. Johnston Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons PNAS, June 11, 2002; 99(12): 8366 - 8371. [Abstract] [Full Text] [PDF]

				M. H. Holmqvist, J. Cao, R. Hernandez-Pineda, M. D. Jacobson, K. I. Carroll, M. A. Sung, M. Betty, P. Ge, K. J. Gilbride, M. E. Brown, et al. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain PNAS, January 22, 2002; 99(2): 1035 - 1040. [Abstract] [Full Text] [PDF]

				M. M. Monaghan, J. S. Trimmer, and K. J. Rhodes Experimental Localization of Kv1 Family Voltage-Gated K+ Channel {alpha} and {beta} Subunits in Rat Hippocampal Formation J. Neurosci., August 15, 2001; 21(16): 5973 - 5983. [Abstract] [Full Text] [PDF]

				M. H. Holmqvist, J. Cao, M. H. Knoppers, M. E. Jurman, P. S. Distefano, K. J. Rhodes, Y. Xie, and W. F. An Kinetic Modulation of Kv4-Mediated A-Current by Arachidonic Acid Is Dependent on Potassium Channel Interacting Proteins J. Neurosci., June 15, 2001; 21(12): 4154 - 4161. [Abstract] [Full Text] [PDF]

				M. A. Castro-Alamancos Origin of Synchronized Oscillations Induced by Neocortical Disinhibition In Vivo J. Neurosci., December 15, 2000; 20(24): 9195 - 9206. [Abstract] [Full Text] [PDF]

				V. Gauck, M. Thomann, D. Jaeger, and A. Borst Spatial Distribution of Low- and High-Voltage-Activated Calcium Currents in Neurons of the Deep Cerebellar Nuclei J. Neurosci., August 1, 2001; 21(15): RC158 - RC158. [Abstract] [Full Text] [PDF]

				M. S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera, and B. Rudy Evidence for the presence of a novel Kv4-mediated A-type K+ channel-modifying factor J. Physiol., December 12, 2001; 537(3): 801 - 809. [Abstract] [Full Text] [PDF]