| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
7-containing nicotinic receptor on rat superior cervical ganglion neurons
-bungarotoxin (Bgt) were studied on isolated rat superior cervical ganglion (SCG) neurons using whole-cell patch clamp recording techniques.
Bgt (50 nM). The toxin-sensitive current constituted on average about half of the peak whole-cell response evoked by ACh.
Bgt-sensitive component of the ACh-evoked current as did intracellular dialysis with an anti-7 monoclonal antibody. The results indicate that the slowly reversible toxin-sensitive response elicited by ACh arises from activation of an unusual class of 7-containing receptor (7-nAChR) similar to that reported previously for rat intracardiac ganglion neurons.
7-nAChR was identified on some SCG neurons by using rapid application of choline to elicit responses. In these cases a biphasic response was obtained, which included a rapidly desensitizing component that was blocked by Bgt in a pseudo-irreversible manner. The pharmacology and kinetics of the responses resembled those previously attributed to 7-nAChRs in a number of other neuronal cell types.
Bgt from SCG neurons revealed two classes of toxin-binding site. The times for toxin dissociation were consistent with those required to reverse blockade of the two kinds of Bgt-sensitive response.
7-nAChR, differing in pharmacology, desensitization and reversibility of Bgt blockade.
This article has been cited by other articles:
|
|
 |
|
  B. Lendvai and E. S. Vizi Nonsynaptic Chemical Transmission Through Nicotinic Acetylcholine Receptors Physiol Rev, April 1, 2008; 88(2): 333 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Mathew, A. J. Law, B. K. Lipska, M. I. Davila-Garcia, E. D. Zamora, S. N. Mitkus, R. Vakkalanka, R. E. Straub, D. R. Weinberger, J. E. Kleinman, et al. {alpha}7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1 Hum. Mol. Genet., December 1, 2007; 16(23): 2921 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Guo, H. Chen, H. L. Puhl III, and S. R. Ikeda Fluorophore-assisted light inactivation produces both targeted and collateral effects on N-type calcium channel modulation in rat sympathetic neurons J. Physiol., October 15, 2006; 576(2): 477 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Beckel, A. Kanai, S.-J. Lee, W. C. de Groat, and L. A. Birder Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells Am J Physiol Renal Physiol, January 1, 2006; 290(1): F103 - F110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fayuk and J. L Yakel Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones J. Physiol., August 1, 2005; 566(3): 759 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Rau, R. D. Johnson, and B. Y. Cooper Nicotinic AChR in Subclassified Capsaicin-Sensitive and -Insensitive Nociceptors of the Rat DRG J Neurophysiol, March 1, 2005; 93(3): 1358 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fischer, A. Orr-Urtreger, L. W Role, and S. Huck Selective deletion of the {alpha}5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse J. Physiol., February 15, 2005; 563(1): 119 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Severance, H. Zhang, Y. Cruz, S. Pakhlevaniants, S. H. Hadley, J. Amin, L. Wecker, C. Reed, and J. Cuevas The {alpha}7 Nicotinic Acetylcholine Receptor Subunit Exists in Two Isoforms that Contribute to Functional Ligand-Gated Ion Channels Mol. Pharmacol., September 1, 2004; 66(3): 420 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. W. Fu, C. A. Nurse, S. M. Farragher, and E. Cutz Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1203 - L1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, A. Orr-Urtreger, J. Chapman, R. Rabinowitz, and A. D. Korczyn Deficiency of Nicotinic Acetylcholine Receptor beta 4 Subunit Causes Autonomic Cardiac and Intestinal Dysfunction Mol. Pharmacol., March 1, 2003; 63(3): 574 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang and J. Cuevas Sigma Receptors Inhibit High-Voltage-Activated Calcium Channels in Rat Sympathetic and Parasympathetic Neurons J Neurophysiol, June 1, 2002; 87(6): 2867 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fujino and D. Oertel Cholinergic Modulation of Stellate Cells in the Mammalian Ventral Cochlear Nucleus J. Neurosci., September 15, 2001; 21(18): 7372 - 7383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ferreira, S. N. Ebert, D. C. Perry, R. P. Yasuda, C. M. Baker, M. I. Dávila-García, K. J. Kellar, and R. A. Gillis Evidence of a Functional alpha 7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 260 - 269. [Abstract] [Full Text]
|
|
|
|
|
|
R. Klink, A. d. K. d'Exaerde, M. Zoli, and J.-P. Changeux Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei J. Neurosci., March 1, 2001; 21(5): 1452 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Khiroug, P. C. Harkness, P. W. Lamb, S. N. Sudweeks, L. Khiroug, N. S. Millar, and J. L. Yakel Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels J. Physiol., April 15, 2002; 540(2): 425 - 434. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
