HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Auger, C. Articles by Marty, A. Search for Related Content PubMed PubMed Citation Articles by Auger, C. Articles by Marty, A. Related Collections Review articles

Quantal currents at single-site central synapses

C. Auger and A. Marty *

The mode of operation of synaptic transmission has been primarily worked out at the vertebrate neuromuscular junction, thus providing a framework for the interpretation of studies at central synapses. However, differences have been found between the two systems, and a coherent model is still lacking for central synapses. Research in this area revolves around several questions. (1) Is the variability of quantal amplitudes determined pre- or postsynaptically? (2) What is the occupancy of postsynaptic receptors following the release of a synaptic vesicle? And (3) does multivesicular release occur at single release sites following one presynaptic action potential? To answer these questions, it is essential to investigate synaptic processes at the level of single release sites. This is technically difficult because of the complex morphology and small dimensions of central synapses. Nevertheless significant advances have been made in the past few years.

This article has been cited by other articles:

				B. M. Stell, P. Rostaing, A. Triller, and A. Marty Activation of Presynaptic GABAA Receptors Induces Glutamate Release from Parallel Fiber Synapses J. Neurosci., August 22, 2007; 27(34): 9022 - 9031. [Abstract] [Full Text] [PDF]

				Y. Pankratov, U. Lalo, A. Verkhratsky, and R. A. North Quantal Release of ATP in Mouse Cortex J. Gen. Physiol., March 26, 2007; 129(3): 257 - 265. [Abstract] [Full Text] [PDF]

				T. Bessaih, L. Bourgeais, C. I. Badiu, D. A. Carter, T. I. Toth, D. Ruano, B. Lambolez, V. Crunelli, and N. Leresche Nucleus-Specific Abnormalities of GABAergic Synaptic Transmission in a Genetic Model of Absence Seizures J Neurophysiol, December 1, 2006; 96(6): 3074 - 3081. [Abstract] [Full Text] [PDF]

				A. A. Biro, N. B. Holderith, and Z. Nusser Release Probability-Dependent Scaling of the Postsynaptic Responses at Single Hippocampal GABAergic Synapses J. Neurosci., November 29, 2006; 26(48): 12487 - 12496. [Abstract] [Full Text] [PDF]

				F. Ricci-Tersenghi, F. Minneci, E. Sola, E. Cherubini, and L. Maggi Multivesicular Release at Developing Schaffer Collateral-CA1 Synapses: An Analytic Approach to Describe Experimental Data J Neurophysiol, July 1, 2006; 96(1): 15 - 26. [Abstract] [Full Text] [PDF]

				C. Cabezas and W. Buno Distinct Transmitter Release Properties Determine Differences in Short-Term Plasticity at Functional and Silent Synapses J Neurophysiol, May 1, 2006; 95(5): 3024 - 3034. [Abstract] [Full Text] [PDF]

				J. Masson, M. Darmon, A. Conjard, N. Chuhma, N. Ropert, M. Thoby-Brisson, A. S. Foutz, S. Parrot, G. M. Miller, R. Jorisch, et al. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J. Neurosci., April 26, 2006; 26(17): 4660 - 4671. [Abstract] [Full Text] [PDF]

				L. Cadetti, D. Tranchina, and W. B. Thoreson A comparison of release kinetics and glutamate receptor properties in shaping rod-cone differences in EPSC kinetics in the salamander retina J. Physiol., December 15, 2005; 569(3): 773 - 788. [Abstract] [Full Text] [PDF]

				G. R. J. Gordon and J. S. Bains Noradrenaline Triggers Multivesicular Release at Glutamatergic Synapses in the Hypothalamus J. Neurosci., December 7, 2005; 25(49): 11385 - 11395. [Abstract] [Full Text] [PDF]

				S. Schein and K. M. Ahmad A Clockwork Hypothesis: Synaptic Release by Rod Photoreceptors Must Be Regular Biophys. J., December 1, 2005; 89(6): 3931 - 3949. [Abstract] [Full Text] [PDF]

				N. R. Wilson, J. Kang, E. V. Hueske, T. Leung, H. Varoqui, J. G. Murnick, J. D. Erickson, and G. Liu Presynaptic Regulation of Quantal Size by the Vesicular Glutamate Transporter VGLUT1 J. Neurosci., June 29, 2005; 25(26): 6221 - 6234. [Abstract] [Full Text] [PDF]

				N. Hosoi, I. Arai, and M. Tachibana Group III Metabotropic Glutamate Receptors and Exocytosed Protons Inhibit L-Type Calcium Currents in Cones But Not in Rods J. Neurosci., April 20, 2005; 25(16): 4062 - 4072. [Abstract] [Full Text] [PDF]

				I. Colin-Le Brun, N. Ferrand, O. Caillard, P. Tosetti, Y. Ben-Ari, and J.-L. Gaiarsa Spontaneous synaptic activity is required for the formation of functional GABAergic synapses in the developing rat hippocampus J. Physiol., August 15, 2004; 559(1): 129 - 139. [Abstract] [Full Text] [PDF]

				P. Petersson, M. Granmo, and J. Schouenborg Properties of an Adult Spinal Sensorimotor Circuit Shaped Through Early Postnatal Experience J Neurophysiol, July 1, 2004; 92(1): 280 - 288. [Abstract] [Full Text] [PDF]

				E. Sola, F. Prestori, P. Rossi, V. Taglietti, and E. D'Angelo Increased neurotransmitter release during long-term potentiation at mossy fibre-granule cell synapses in rat cerebellum J. Physiol., June 15, 2004; 557(3): 843 - 861. [Abstract] [Full Text] [PDF]

				G. Chen, N. C. Harata, and R. W. Tsien From the Cover: Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses PNAS, January 27, 2004; 101(4): 1063 - 1068. [Abstract] [Full Text] [PDF]

				Y. V. Pankratov and O. A. Krishtal Distinct Quantal Features of AMPA and NMDA Synaptic Currents in Hippocampal Neurons: Implication of Glutamate Spillover and Receptor Saturation Biophys. J., November 1, 2003; 85(5): 3375 - 3387. [Abstract] [Full Text] [PDF]

				L.-W. Gong, I. Hafez, G. Alvarez de Toledo, and M. Lindau Secretory Vesicles Membrane Area Is Regulated in Tandem with Quantal Size in Chromaffin Cells J. Neurosci., August 27, 2003; 23(21): 7917 - 7921. [Abstract] [Full Text] [PDF]

				K. M. Franks, C. F. Stevens, and T. J. Sejnowski Independent Sources of Quantal Variability at Single Glutamatergic Synapses J. Neurosci., April 15, 2003; 23(8): 3186 - 3195. [Abstract] [Full Text] [PDF]

				R. Conti and J. Lisman The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release PNAS, April 15, 2003; 100(8): 4885 - 4890. [Abstract] [Full Text] [PDF]

				S. Karunanithi, L. Marin, K. Wong, and H. L. Atwood Quantal Size and Variation Determined by Vesicle Size in Normal and Mutant Drosophila Glutamatergic Synapses J. Neurosci., December 1, 2002; 22(23): 10267 - 10276. [Abstract] [Full Text] [PDF]

				J. F. Wesseling and D. C. Lo Limit on the Role of Activity in Controlling the Release-Ready Supply of Synaptic Vesicles J. Neurosci., November 15, 2002; 22(22): 9708 - 9720. [Abstract] [Full Text] [PDF]

				E. A. Schwartz Transport-Mediated Synapses in the Retina Physiol Rev, October 1, 2002; 82(4): 875 - 891. [Abstract] [Full Text] [PDF]

				E. Hanse and B. Gustafsson Release Dependence to a Paired Stimulus at a Synaptic Release Site with a Small Variable Pool of Immediately Releasable Vesicles J. Neurosci., June 1, 2002; 22(11): 4381 - 4387. [Abstract] [Full Text] [PDF]

				C. J. Meinrenken, J. G. G. Borst, and B. Sakmann Calcium Secretion Coupling at Calyx of Held Governed by Nonuniform Channel-Vesicle Topography J. Neurosci., March 1, 2002; 22(5): 1648 - 1667. [Abstract] [Full Text] [PDF]

				G. Fuhrmann, I. Segev, H. Markram, and M. Tsodyks Coding of Temporal Information by Activity-Dependent Synapses J Neurophysiol, January 1, 2002; 87(1): 140 - 148. [Abstract] [Full Text] [PDF]

				A. Barberis, E. Cherubini, and J. W. Mozrzymas Zinc Inhibits Miniature GABAergic Currents by Allosteric Modulation of GABAA Receptor Gating J. Neurosci., December 1, 2000; 20(23): 8618 - 8627. [Abstract] [Full Text] [PDF]