J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Volume 531, Number 1, 165-170, February 15, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vidruk, E. H.
Right arrow Articles by Mitchell, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vidruk, E. H.
Right arrow Articles by Mitchell, G. S.
The Journal of Physiology (2001), 531.1, pp. 165-170
© Copyright 2001 The Physiological Society

Responses of single-unit carotid body chemoreceptors in adult rats

Edward H. Vidruk, E. Burt Olson Jr, Liming Ling* and Gordon S. Mitchell†

John Rankin Laboratory of Pulmonary Medicine and †Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53705 and *Department of Medicine, Harvard Medical School, Boston, MA 02115, USA

  1. Our goal was to describe the in situ responses in rats of single-unit carotid body chemoreceptors to changes in arterial PO2 and PCO2. We identified single-unit carotid chemoreceptor activity in male, adult Sprague-Dawley rats by their rapid responses to i.v. NaCN (20 µg) and transient (10 s) asphyxia.

  2. Single-unit chemoreceptor responses to isocapnic changes in oxygenation within the arterial oxygen pressure range 34-114 mmHg were described by the power function: fdis = 74010(Pa,O2)-2·5; (r2 = 0·6), where fdis is the discharge frequency (spikes s-1), Pa,O2 is the arterial oxygen partial pressure (mmHg) and r2 is the correlation coefficient.

  3. The responses to iso-oxic changes in CO2, assumed to be linear, had a slope of 0·089 spikes s-1 (mmHg Pa,CO2)-1 (r2 = 0·7).

  4. We conclude that carotid body chemoreceptors in adult rats have responses to changes in Pa,O2 and Pa,CO2 similar to those of other species.



This article has been cited by other articles:


Home page
 J. Physiol.Home page
D. S. Ward, W. A. Voter, and S. Karan
The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans
J. Physiol., July 15, 2007; 582(2): 859 - 869.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. D. Kline, A. Ramirez-Navarro, and D. L. Kunze
Adaptive Depression in Synaptic Transmission in the Nucleus of the Solitary Tract after In Vivo Chronic Intermittent Hypoxia: Evidence for Homeostatic Plasticity
J. Neurosci., April 25, 2007; 27(17): 4663 - 4673.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead
Neonatal maternal separation induces sex-specific augmentation of the hypercapnic ventilatory response in awake rat
J Appl Physiol, April 1, 2007; 102(4): 1416 - 1421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Day and R. J. A. Wilson
Specific carotid body chemostimulation is sufficient to elicit phrenic poststimulus frequency decline in a novel in situ dual-perfused rat preparation
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R532 - R544.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. J Madden and S. F Morrison
Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats
J. Physiol., July 15, 2005; 566(2): 559 - 573.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. F. Donnelly, I. Kim, C. Carle, and J. L. Carroll
Perinatal hyperoxia for 14 days increases nerve conduction time and the acute unitary response to hypoxia of rat carotid body chemoreceptors
J Appl Physiol, July 1, 2005; 99(1): 114 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. J. Cummings and R. J. A. Wilson
Time-dependent modulation of carotid body afferent activity during and after intermittent hypoxia
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1571 - R1580.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. J. Golder, D. D. Fuller, P. W. Davenport, R. D. Johnson, P. J. Reier, and D. C. Bolser
Respiratory Motor Recovery after Unilateral Spinal Cord Injury: Eliminating Crossed Phrenic Activity Decreases Tidal Volume and Increases Contralateral Respiratory Motor Output
J. Neurosci., March 15, 2003; 23(6): 2494 - 2501.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
X. Wang, B.-R. Wang, X.-L. Duan, P. Zhang, Y.-Q. Ding, Y. Jia, X.-Y. Jiao, and G. Ju
Strong Expression of Interleukin-1 Receptor Type I in the Rat Carotid Body
J. Histochem. Cytochem., December 1, 2002; 50(12): 1677 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. D. Kline, K. N. Takacs, E. Ficker, and D. L. Kunze
Dopamine Modulates Synaptic Transmission in the Nucleus of the Solitary Tract
J Neurophysiol, November 1, 2002; 88(5): 2736 - 2744.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 The Physiological Society.