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Increased Ca²⁺ buffering enhances Ca²⁺-dependent process

Robert S. Zucker

The title for this Perspectives article must have a misprint - surely, it should say, 'Increased Ca²⁺ buffering diminishes Ca²⁺-dependent process'. In fact, the title is correct, as shown in the startling results reported in a remarkable study appearing in this issue of The Journal of Physiology (Rozov et al. 2001). The venerable Neher and Sakmann team has rejoined forces, combining the talents of the two Max-Planck-Institutes in Göttingen and Heidelberg to analyse totally counterintuitive results: perfusing presynaptic neurons with exogenous BAPTA can enhance synaptic facilitation.