HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baekey, D. M. Articles by Shannon, R. Search for Related Content PubMed PubMed Citation Articles by Baekey, D. M. Articles by Shannon, R.

Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the cat

David M. Baekey *, Kendall F. Morris *†, Christian Gestreau *, Zhongzeng Li *, Bruce G. Lindsey *† and Roger Shannon *†

1. This study addressed the hypothesis that ventrolateral medullary respiratory neurones participate in the control of laryngeal motoneurones during both eupnoea and coughing.
2. Data were obtained from 28 mid-collicular decerebrated, artificially ventilated cats. Cough-like motor patterns (fictive cough) in phrenic, lumbar and recurrent laryngeal nerves were elicited by mechanical stimulation of the intrathoracic trachea. Microelectrode arrays were used to monitor simultaneously several neurones in the ventral respiratory group, including the Bötzinger and pre-Bötzinger complexes. Spike trains were evaluated for responses during fictive cough and evidence of functional connectivity with spike-triggered averages of efferent recurrent laryngeal nerve activity.
3. Primary features were observed in averages triggered by 94 of 332 (28 %) neurones. An offset biphasic wave with a positive time lag was present in the unrectified average for 10 inspiratory and 13 expiratory neurones. These trigger neurones were respectively identified as inspiratory laryngeal motoneurones with augmenting, decrementing, plateau and 'other' discharge patterns, and expiratory laryngeal motoneurones with decrementing firing patterns.
4. Rectified averages triggered by inspiratory neurones included 37 offset peaks, 11 central peaks and one offset trough. Averages triggered by expiratory neurones had 12 offset peaks, six central peaks and four offset troughs. Relationships inferred from these features included premotor actions of inspiratory neurones with augmenting, decrementing, plateau and 'other' patterns on inspiratory laryngeal motoneurones, and premotor actions of decrementing and 'other' expiratory neurones on expiratory laryngeal motoneurones. Corresponding changes in neuronal firing patterns during fictive cough supported these inferences.
5. The data confirm and extend previous results on the control of laryngeal motoneurones during eupnoea and support the hypothesis that the same premotor neurones help to shape motoneurone firing patterns during both eupnoea and coughing.

This article has been cited by other articles:

				S. B. Mazzone, L. McLennan, A. E. McGovern, G. F. Egan, and M. J. Farrell Representation of Capsaicin-evoked Urge-to-Cough in the Human Brain Using Functional Magnetic Resonance Imaging Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 327 - 332. [Abstract] [Full Text] [PDF]

				K. Shiba, K. Nakazawa, K. Ono, and T. Umezaki Multifunctional Laryngeal Premotor Neurons: Their Activities during Breathing, Coughing, Sneezing, and Swallowing J. Neurosci., May 9, 2007; 27(19): 5156 - 5162. [Abstract] [Full Text] [PDF]

				I. Poliacek, L. W.-C. Corrie, C. Wang, M. J. Rose, and D. C. Bolser Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism J Appl Physiol, March 1, 2007; 102(3): 1014 - 1021. [Abstract] [Full Text] [PDF]

				T. E. Dick, R. Shannon, B. G. Lindsey, S. C. Nuding, L. S. Segers, D. M. Baekey, and K. F. Morris Arterial pulse modulated activity is expressed in respiratory neural output J Appl Physiol, August 1, 2005; 99(2): 691 - 698. [Abstract] [Full Text] [PDF]

				D. M. Baekey, K. F. Morris, S. C. Nuding, L. S. Segers, B. G. Lindsey, and R. Shannon Ventrolateral medullary respiratory network participation in the expiration reflex in the cat J Appl Physiol, June 1, 2004; 96(6): 2057 - 2072. [Abstract] [Full Text] [PDF]

				T. E. Dick and K. F. Morris Quantitative analysis of cardiovascular modulation in respiratory neural activity J. Physiol., May 1, 2004; 556(3): 959 - 970. [Abstract] [Full Text] [PDF]

				K. F. Morris, D. M. Baekey, S. C. Nuding, T. E. Dick, R. Shannon, and B. G. Lindsey Plasticity in Respiratory Motor Control: Invited Review: Neural network plasticity in respiratory control J Appl Physiol, March 1, 2003; 94(3): 1242 - 1252. [Abstract] [Full Text] [PDF]

				D. M. Baekey, K. F. Morris, S. C. Nuding, L. S. Segers, B. G. Lindsey, and R. Shannon Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat J Appl Physiol, January 1, 2003; 94(1): 93 - 100. [Abstract] [Full Text] [PDF]

				F. Roda, C. Gestreau, and A. L. Bianchi Discharge Patterns of Hypoglossal Motoneurons During Fictive Breathing, Coughing, and Swallowing J Neurophysiol, April 1, 2002; 87(4): 1703 - 1711. [Abstract] [Full Text] [PDF]