J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Volume 536, Number 1, 3-19, October 1, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prakriya, M.
Right arrow Articles by Lewis, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prakriya, M.
Right arrow Articles by Lewis, R. S.
Journal of Physiology (2001), 536.1, pp. 3-19
© Copyright 2001 The Physiological Society

Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP3 receptors


Murali Prakriya and Richard S. Lewis


Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA

  1. The effects of the IP3-receptor antagonist 2-aminoethyldiphenyl borate (2-APB) on the Ca2+ release-activated Ca2+ current (ICRAC) in Jurkat human T cells, DT40 chicken B cells and rat basophilic leukaemia (RBL) cells were examined.
  2. 2-APB elicited both stimulatory and inhibitory effects on Ca2+ influx through CRAC channels. At concentrations of 1-5 µM, 2-APB enhanced Ca2+ entry in intact cells and increased ICRAC amplitude by up to fivefold. At levels >= 10 µM, 2-APB caused a transient enhancement of ICRAC followed by inhibition.
  3. 2-APB altered the kinetics of fast Ca2+-dependent inactivation of ICRAC. At concentrations of 1-5 µM, 2-APB increased the rate of fast inactivation. In contrast, 2-APB at higher concentrations (>= 10 µM) reduced or completely blocked inactivation.
  4. 2-APB inhibited Ca2+ efflux from mitochondria.
  5. 2-APB inhibited ICRAC more potently when applied extracellularly than intracellularly. Furthermore, increased protonation of 2-APB at low pH did not affect potentiation or inhibition. Thus, 2-APB may have an extracellular site of action.
  6. Neither ICRAC activation by passive store depletion nor the effects of 2-APB were altered by intracellular dialysis with 500 µg ml-1 heparin.
  7. ICRAC is present in wild-type as well as mutant DT40 B cells lacking all three IP3 receptor isoforms. 2-APB also potentiates and inhibits ICRAC in both cell types, indicating that 2-APB exerts its effects independently of IP3 receptors.
  8. Our results show that CRAC channel activation does not require physical interaction with IP3 receptors as proposed in the conformational coupling model. Potentiation of ICRAC by 2-APB may be a useful diagnostic feature for positive identification of putative CRAC channel genes, and provides a novel tool for exploring the physiological functions of store-operated channels.



This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
X.-C. Ru, L.-B. Qian, Q. Gao, Y.-F. Li, I. C. Bruce, and Q. Xia
Alcohol Induces Relaxation of Rat Thoracic Aorta and Mesenteric Arterial Bed
Alcohol Alcohol., September 1, 2008; 43(5): 537 - 543.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Schindl, J. Bergsmann, I. Frischauf, I. Derler, M. Fahrner, M. Muik, R. Fritsch, K. Groschner, and C. Romanin
2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size
J. Biol. Chem., July 18, 2008; 283(29): 20261 - 20267.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. I. DeHaven, J. T. Smyth, R. R. Boyles, G. S. Bird, and J. W. Putney Jr.
Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry
J. Biol. Chem., July 11, 2008; 283(28): 19265 - 19273.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Peinelt, A. Lis, A. Beck, A. Fleig, and R. Penner
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
J. Physiol., July 1, 2008; 586(13): 3061 - 3073.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. M. Bolotina
Orai, STIM1 and iPLA2{beta}: a view from a different perspective
J. Physiol., July 1, 2008; 586(13): 3035 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Zhang, J. A. Kozak, W. Jiang, A. V. Yeromin, J. Chen, Y. Yu, A. Penna, W. Shen, V. Chi, and M. D. Cahalan
Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3
J. Biol. Chem., June 20, 2008; 283(25): 17662 - 17671.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T. L. Lewis, K. M. Brundage, R. A. Brundage, and J. B. Barnett
3,4-Dichloropropionanilide (DCPA) Inhibits T-Cell Activation by Altering the Intracellular Calcium Concentration following Store Depletion
Toxicol. Sci., May 1, 2008; 103(1): 97 - 107.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Parvez, A. Beck, C. Peinelt, J. Soboloff, A. Lis, M. Monteilh-Zoller, Donald. L. Gill, A. Fleig, and R. Penner
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
FASEB J, March 1, 2008; 22(3): 752 - 761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Johnston, C. Carson, A. D. Lyons, R. A. Davidson, and K. D. McCloskey
Cholinergic-induced Ca2+ signaling in interstitial cells of Cajal from the guinea pig bladder
Am J Physiol Renal Physiol, March 1, 2008; 294(3): F645 - F655.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. L. Domeier, A. V. Zima, J. T. Maxwell, S. Huke, G. A. Mignery, and L. A. Blatter
IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H596 - H604.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Liu, K. T. Cheng, B. C. Bandyopadhyay, B. Pani, A. Dietrich, B. C. Paria, W. D. Swaim, D. Beech, E. Yildrim, B. B. Singh, et al.
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1( / ) mice
PNAS, October 30, 2007; 104(44): 17542 - 17547.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
M. Yamashita, L. Navarro-Borelly, B. A. McNally, and M. Prakriya
Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating
J. Gen. Physiol., October 29, 2007; 130(5): 525 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Hashitani and H. Suzuki
Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ
J. Physiol., September 1, 2007; 583(2): 505 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. A. Ene, A. Kalmbach, and K. Kandler
Metabotropic Glutamate Receptors in the Lateral Superior Olive Activate TRP-Like Channels: Age- and Experience-Dependent Regulation
J Neurophysiol, May 1, 2007; 97(5): 3365 - 3375.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. J. Leuenroth, D. Okuhara, J. D. Shotwell, G. S. Markowitz, Z. Yu, S. Somlo, and C. M. Crews
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
PNAS, March 13, 2007; 104(11): 4389 - 4394.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Y. Hung and N. S. Magoski
Activity-Dependent Initiation of a Prolonged Depolarization in Aplysia Bag Cell Neurons: Role for a Cation Channel
J Neurophysiol, March 1, 2007; 97(3): 2465 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. Tao and A. L. Harris
2-Aminoethoxydiphenyl Borate Directly Inhibits Channels Composed of Connexin26 and/or Connexin32
Mol. Pharmacol., February 1, 2007; 71(2): 570 - 579.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhao, N. Weisleder, X. Han, Z. Pan, J. Parness, M. Brotto, and J. Ma
Azumolene Inhibits a Component of Store-operated Calcium Entry Coupled to the Skeletal Muscle Ryanodine Receptor
J. Biol. Chem., November 3, 2006; 281(44): 33477 - 33486.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. A. Kachoei, R. J. Knox, D. Uthuza, S. Levy, L. K. Kaczmarek, and N. S. Magoski
A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia
J Neurophysiol, November 1, 2006; 96(5): 2688 - 2698.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Singaravelu, C. Lohr, and J. W. Deitmer
Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes.
J. Neurosci., September 13, 2006; 26(37): 9579 - 9592.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. M. Wu, J. Buchanan, R. M. Luik, and R. S. Lewis
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
J. Cell Biol., September 11, 2006; 174(6): 803 - 813.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
R. M. Luik, M. M. Wu, J. Buchanan, and R. S. Lewis
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions
J. Cell Biol., September 11, 2006; 174(6): 815 - 825.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
M. Prakriya and R. S. Lewis
Regulation of CRAC Channel Activity by Recruitment of Silent Channels to a High Open-probability Gating Mode
J. Gen. Physiol., August 28, 2006; 128(3): 373 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. C. Mercer, W. I. DeHaven, J. T. Smyth, B. Wedel, R. R. Boyles, G. S. Bird, and J. W. Putney Jr
Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1
J. Biol. Chem., August 25, 2006; 281(34): 24979 - 24990.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Soboloff, M. A. Spassova, X. D. Tang, T. Hewavitharana, W. Xu, and D. L. Gill
Orai1 and STIM Reconstitute Store-operated Calcium Channel Function
J. Biol. Chem., July 28, 2006; 281(30): 20661 - 20665.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
O. Dellis, S. G. Dedos, S. C. Tovey, Taufiq-Ur-Rahman, S. J. Dubel, and C. W. Taylor
Ca2+ entry through plasma membrane IP3 receptors.
Science, July 14, 2006; 313(5784): 229 - 233.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Sullivan, M. A. Grummer, F.-X. Yi, and I. M. Bird
Pregnancy-Enhanced Endothelial Nitric Oxide Synthase (eNOS) Activation in Uterine Artery Endothelial Cells Shows Altered Sensitivity to Ca2+, U0126, and Wortmannin But Not LY294002--Evidence that Pregnancy Adaptation of eNOS Activation Occurs at Multiple Levels of Cell Signaling
Endocrinology, May 1, 2006; 147(5): 2442 - 2457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B.-X. Zhang, X. Ma, W. Zhang, C.-K. Yeh, A. Lin, J. Luo, E. A. Sprague, R. H. Swerdlow, and M. S. Katz
Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria
Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1321 - C1333.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
M. Li, J. Jiang, and L. Yue
Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7
J. Gen. Physiol., April 24, 2006; 127(5): 525 - 537.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Gartner, D. G. Polnau, V. Staiger, C. Sciarretta, L. Minichiello, H. Thoenen, T. Bonhoeffer, and M. Korte
Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling.
J. Neurosci., March 29, 2006; 26(13): 3496 - 3504.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Spassova, J. Soboloff, L.-P. He, W. Xu, M. A. Dziadek, and D. L. Gill
STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels.
PNAS, March 14, 2006; 103(11): 4040 - 4045.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. R. Cima, J. M. Dubach, A. M. Wieland, B. M. Walsh, and D. I. Soybel
Intracellular Ca2+ and Zn2+ signals during monochloramine-induced oxidative stress in isolated rat colon crypts
Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G250 - G261.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Dobrydneva, C. J. Abelt, B. Dovel, C. M. Thadigiri, R. L. Williams, and P. F. Blackmore
2-Aminoethoxydiphenyl Borate as a Prototype Drug for a Group of Structurally Related Calcium Channel Blockers in Human Platelets
Mol. Pharmacol., January 1, 2006; 69(1): 247 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-P. Lievremont, T. Numaga, G. Vazquez, L. Lemonnier, Y. Hara, E. Mori, M. Trebak, S. E. Moss, G. S. Bird, Y. Mori, et al.
The Role of Canonical Transient Receptor Potential 7 in B-cell Receptor-activated Channels
J. Biol. Chem., October 21, 2005; 280(42): 35346 - 35351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Kotecha and M. A. Hill
Myogenic contraction in rat skeletal muscle arterioles: smooth muscle membrane potential and Ca2+ signaling
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1326 - H1334.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Feske, M. Prakriya, A. Rao, and R. S. Lewis
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients
J. Exp. Med., September 6, 2005; 202(5): 651 - 662.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J.-P. Lievremont, G. S. Bird, and J. W. Putney Jr.
Mechanism of Inhibition of TRPC Cation Channels by 2-Aminoethoxydiphenylborane
Mol. Pharmacol., September 1, 2005; 68(3): 758 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Li, A. C. Roberts, and D. L. Glanzman
Synaptic Facilitation and Behavioral Dishabituation in Aplysia: Dependence on Release of Ca2+ from Postsynaptic Intracellular Stores, Postsynaptic Exocytosis, and Modulation of Postsynaptic AMPA Receptor Efficacy
J. Neurosci., June 8, 2005; 25(23): 5623 - 5637.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Gu, R.-L. Lin, H.-Z. Hu, M. X. Zhu, and L.-Y. Lee
2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels
Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L932 - L941.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-K. Chung, A. D. Guler, and M. J. Caterina
Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3
J. Biol. Chem., April 22, 2005; 280(16): 15928 - 15941.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. B. Parekh and J. W. Putney Jr.
Store-Operated Calcium Channels
Physiol Rev, April 1, 2005; 85(2): 757 - 810.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. R Robbins, S. M. Lee, A. H Filipovich, P. Szigligeti, L. Neumeier, M. Petrovic, and L. Conforti
Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels
J. Physiol., April 1, 2005; 564(1): 131 - 143.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-P. He, T. Hewavitharana, J. Soboloff, M. A. Spassova, and D. L. Gill
A Functional Link between Store-operated and TRPC Channels Revealed by the 3,5-Bis(trifluoromethyl)pyrazole Derivative, BTP2
J. Biol. Chem., March 25, 2005; 280(12): 10997 - 11006.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Bollimuntha, B. B. Singh, S. Shavali, S. K. Sharma, and M. Ebadi
TRPC1-mediated Inhibition of 1-Methyl-4-phenylpyridinium Ion Neurotoxicity in Human SH-SY5Y Neuroblastoma Cells
J. Biol. Chem., January 21, 2005; 280(3): 2132 - 2140.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
R. Laporte, A. Hui, and I. Laher
Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle
Pharmacol. Rev., December 1, 2004; 56(4): 439 - 513.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Basset, F.-X. Boittin, O. M. Dorchies, J.-Y. Chatton, C. van Breemen, and U. T. Ruegg
Involvement of Inositol 1,4,5-Trisphosphate in Nicotinic Calcium Responses in Dystrophic Myotubes Assessed by Near-plasma Membrane Calcium Measurement
J. Biol. Chem., November 5, 2004; 279(45): 47092 - 47100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. D. Garcia, T. Shah, and J. Garcia
Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice
Am J Physiol Cell Physiol, October 1, 2004; 287(4): C1048 - C1057.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. I. Zakharov, T. Smani, Y. Dobrydneva, F. Monje, C. Fichandler, P. F. Blackmore, and V. M. Bolotina
Diethylstilbestrol Is a Potent Inhibitor of Store-Operated Channels and Capacitative Ca2+ Influx
Mol. Pharmacol., September 1, 2004; 66(3): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-Z. Hu, Q. Gu, C. Wang, C. K. Colton, J. Tang, M. Kinoshita-Kawada, L.-Y. Lee, J. D. Wood, and M. X. Zhu
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
J. Biol. Chem., August 20, 2004; 279(34): 35741 - 35748.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Isshiki, A. Mutoh, and T. Fujita
Subcortical Ca2+ Waves Sneaking Under the Plasma Membrane in Endothelial Cells
Circ. Res., August 6, 2004; 95(3): e11 - e21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Lamont and W. G. Wier
Different roles of ryanodine receptors and inositol (1,4,5)-trisphosphate receptors in adrenergically stimulated contractions of small arteries
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H617 - H625.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
V. M. Bolotina
Store-Operated Channels: Diversity and Activation Mechanisms
Sci. Signal., July 27, 2004; 2004(243): pe34 - pe34.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
D. L. Gill and R. L. Patterson
Toward a Consensus on the Operation of Receptor-Induced Calcium Entry Signals
Sci. Signal., July 27, 2004; 2004(243): pe39 - pe39.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina
2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3
J. Neurosci., June 2, 2004; 24(22): 5177 - 5182.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. H. Nam, J.-E. Woo, D.-Y. Uhm, and S. J. Kim
Membrane-delimited Regulation of Novel Background K+ Channels by MgATP in Murine Immature B Cells
J. Biol. Chem., May 14, 2004; 279(20): 20643 - 20654.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. M. Bautista and R. S. Lewis
Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells
J. Physiol., May 1, 2004; 556(3): 805 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Ay, Y. S. Prakash, C. M. Pabelick, and G. C. Sieck
Store-operated Ca2+ entry in porcine airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L909 - L917.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Zitt, B. Strauss, E. C. Schwarz, N. Spaeth, G. Rast, A. Hatzelmann, and M. Hoth
Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2
J. Biol. Chem., March 26, 2004; 279(13): 12427 - 12437.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Ducret, A.-M. Vacher, and P. Vacher
Effects of Prolactin on Ionic Membrane Conductances in the Human Malignant Astrocytoma Cell Line U87-MG
J Neurophysiol, March 1, 2004; 91(3): 1203 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
A. V. Yeromin, J. Roos, K. A. Stauderman, and M. D. Cahalan
A Store-operated Calcium Channel in Drosophila S2 Cells
J. Gen. Physiol., January 26, 2004; 123(2): 167 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Munsch, M. Freichel, V. Flockerzi, and H.-C. Pape
Contribution of transient receptor potential channels to the control of GABA release from dendrites
PNAS, December 23, 2003; 100(26): 16065 - 16070.
[Abstract] [Full Text] [PDF]

Home page