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The paracellular component of water flow in the rat submandibular salivary gland

Masataka Murakami, Bruria Shachar-Hill *, Martin C. Steward † and A. E. Hill *

1. The pathway of water flow during salivary secretion by the isolated, perfused rat submandibular gland was examined using a family of homologous radiodextran molecules as probes of paracellular fluid transfer.
2. The secretion/perfusate ratio (S/P) of the secreted probes versus molecular radius during fluid secretion evoked by ACh could be resolved into two components: one that fitted a free-diffusion (Stokes-Einstein) curve and indicated diffusion through large channels, and a convective component that was linearly related to radius.
3. The convective component had a cut-off point at 0.5 nm (5 Å) radius and an S/P intercept of near 1.0 at the radius of water, which indicates that most of the volume flow was paracellular.
4. The nature of such a paracellular flow is discussed together with the possible integration of this volume flow with the cellular transport of ions, resulting in an isotonic primary secretion from the gland.

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