| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
There are only a few reports of the influence of imposed flow on an active lymph pump under conditions of controlled intraluminal pressure. Thus, the mechanisms are not clearly defined. Rat mesenteric lymphatics and thoracic ducts were isolated, cannulated and pressurized. Input and output pressures were adjusted to impose various flows. Lymphatic systolic and diastolic diameters were measured and used to determine contraction frequency and pump flow indices. Imposed flow inhibited the active lymph pump in both mesenteric lymphatics and in the thoracic duct. The active pump of the thoracic duct appeared more sensitive to flow than did the active pump of the mesenteric lymphatics. Imposed flow reduced the frequency and amplitude of the contractions and accordingly the active pump flow. Flow-induced inhibition of the active lymph pump followed two temporal patterns. The first pattern was a rapidly developing inhibition of contraction frequency. Upon imposition of flow, the contraction frequency immediately fell and then partially recovered over time during continued flow. This effect was dependent on the magnitude of imposed flow, but did not depend on the direction of flow. The effect also depended upon the rate of change in the direction of flow. The second pattern was a slowly developing reduction of the amplitude of the lymphatic contractions, which increased over time during continued flow. The inhibition of contraction amplitude was dependent on the direction of the imposed flow, but independent of the magnitude of flow. Nitric oxide was partly but not completely responsible for the influence of flow on the mesenteric lymph pump. Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N G-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow.
This article has been cited by other articles:
|
|
 |
|
  A. J. Macdonald, K. P. Arkill, G. R. Tabor, N. G. McHale, and C. P. Winlove Modeling flow in collecting lymphatic vessels: one-dimensional flow through a series of contractile elements Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H305 - H313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Dougherty, M. J. Davis, D. C. Zawieja, and M. Muthuchamy Calcium sensitivity and cooperativity of permeabilized rat mesenteric lymphatics Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1524 - R1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Quick, A. M. Venugopal, R. M. Dongaonkar, G. A. Laine, and R. H. Stewart First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2144 - H2149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Venugopal, R. H. Stewart, G. A. Laine, R. M. Dongaonkar, and C. M. Quick Lymphangion coordination minimally affects mean flow in lymphatic vessels Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1183 - H1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Meisner, R. H. Stewart, G. A. Laine, and C. M. Quick Lymphatic vessels transition to state of summation above a critical contraction frequency Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R200 - R208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Breslin, N. Gaudreault, K. D. Watson, R. Reynoso, S. Y. Yuan, and M. H. Wu Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H709 - H718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Quick, A. M. Venugopal, A. A. Gashev, D. C. Zawieja, and R. H. Stewart Intrinsic pump-conduit behavior of lymphangions Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1510 - R1518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Yu. Gasheva, D. C. Zawieja, and A. A. Gashev Contraction-initiated NO-dependent lymphatic relaxation: a self-regulatory mechanism in rat thoracic duct J. Physiol., September 15, 2006; 575(3): 821 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Negrini Lymph flow modulation: the tricks of a performant machinery J. Physiol., September 15, 2006; 575(3): 687 - 687. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Gashev, M. D. Delp, and D. C. Zawieja Inhibition of active lymph pump by simulated microgravity in rats Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2295 - H2308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hosaka, S. E. Rayner, P.-Y. von der Weid, J. Zhao, M. S. Imtiaz, and D. F. van Helden Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H813 - H822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kousai, R. Mizuno, F. Ikomi, and T. Ohhashi ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2585 - H2597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hagendoorn, T. P. Padera, S. Kashiwagi, N. Isaka, F. Noda, M. I. Lin, P. L. Huang, W. C. Sessa, D. Fukumura, and R. K. Jain Endothelial Nitric Oxide Synthase Regulates Microlymphatic Flow via Collecting Lymphatics Circ. Res., July 23, 2004; 95(2): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirasawa and J. N. Benoit Stretch-induced calcium sensitization of rat lymphatic smooth muscle Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2573 - H2577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hosaka, R. Mizuno, and T. Ohhashi Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2015 - H2025. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
