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Shedding new light on brain metabolism and glial function

Denis Burdakov and Frances M. Ashcroft

Without a continuous supply of nutrients, the brain dies within a few minutes. Blood flow and glucose uptake are so tightly coupled to neuronal function that techniques which image these processes (e.g. PET) are valuable monitors of neuronal activity. However, in order to understand brain metabolism completely, and to find specific molecular targets for therapeutic intervention, it is also essential to study the dynamics of metabolism in single living brain cells.

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