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Excitability of human muscle afferents studied using threshold tracking of the H reflex

Cindy S.-Y. Lin, Jane H. L. Chan, Emmanuel Pierrot-Deseilligny * and David Burke

In human peripheral nerves, physiological evidence has been presented for a number of biophysical differences between cutaneous afferents and motor axons. The differences in strength-duration properties for cutaneous afferents and motor axons in the median nerve have been attributed to greater expression of a persistent Na⁺ conductance (I_Na,P) on cutaneous afferents. However, it is unclear whether the biophysical properties of human group Ia afferents differ from those of cutaneous afferents. The present studies were undertaken to determine whether the properties of human group Ia afferents can be studied indirectly using 'threshold tracking' to measure the excitability changes in the H reflex, and to determine whether the excitability of group Ia afferents differs from that of cutaneous afferents. The strength-duration properties of the soleus H reflex and soleus motor axons were measured at rest and during sustained voluntary contractions. Similar experiments were performed on the median nerve at the wrist to study the strength-duration properties of cutaneous afferents, motor axons and H reflex of the thenar muscles. In addition, the technique of 'latent addition' was used to determine whether there was a difference in a low-threshold conductance on soleus Ia afferent and motor axons. The present findings indicate that the strength-duration time constant (_SD) for the H reflex is longer than that for motor axons, but similar to that for cutaneous afferents. There were no differences in _SD for the soleus H reflex at rest and during contractions, suggesting that _SD for the H reflex is largely unaffected by changes in synaptic or motoneurone properties. Finally, the difference in latent addition suggests that the longer _SD of the soleus H reflex may indeed be due to greater activity of a persistent Na⁺ conductance on Ia afferents than on soleus motor axons.

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