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J Physiol Volume 546, Number 1, 5-18, January 1, 2003 DOI: 10.1113/jphysiol.2002.026468
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Journal of Physiology (2003), 546.1, pp. 5-18
© Copyright 2002 D 2003 The Physiological Society
DOI: 10.1113/jphysiol.2002.026468

Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito)

Rajan Sah, Rafael J. Ramirez, Gavin Y. Oudit, Dominica Gidrewicz, Maria G. Trivieri, Carsten Zobel * and Peter H. Backx

Departments of Physiology and Medicine, University of Toronto, Heart & Stroke/Richard Lewar Centre, University of Toronto, Room 68, Fitzgerald Building, 150 College Street, Toronto, Ontario, M5S 3E2, Canada and * Laboratory of Muscle Research and Molecular Cardiology, University of Cologne, Cologne, Germany

The cardiac action potential (AP) is critical for initiating and coordinating myocyte contraction. In particular, the early repolarization period of the AP (phase 1) strongly influences the time course and magnitude of the whole-cell intracellular Ca2+ transient by modulating trans-sarcolemmal Ca2+ influx through L-type Ca2+ channels (ICa,L) and Na-Ca exchangers (ICa,NCX). The transient outward potassium current (Ito) has kinetic properties that make it especially effective in modulating the trajectory of phase 1 repolarization and thereby cardiac excitation-contraction coupling (ECC). The magnitude of Ito varies greatly during cardiac development, between different regions of the heart, and is invariably reduced as a result of heart disease, leading to corresponding variations in ECC. In this article, we review evidence supporting a modulatory role of Ito in ECC through its influence on ICa,L, and possibly ICa,NCX. We also discuss differential effects of Ito on ECC between different species, between different regions of the heart and in heart disease.



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