HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 547/3/971    most recent 2002.037937v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosenmeier, J. B. Articles by Joyner, M. J. Search for Related Content PubMed PubMed Citation Articles by Rosenmeier, J. B. Articles by Joyner, M. J.

₁- and ₂-adrenergic vasoconstriction is blunted in contracting human muscle

Jaya B. Rosenmeier, Frank A. Dinenno, Sandy J. Fritzlar and Michael J. Joyner

Sympathetic vasoconstriction is blunted in the vascular beds of contracting skeletal muscles. We sought to determine whether this blunted vasoconstriction is specific for post-junctional ₁- or ₂-adrenergic receptors. We measured forearm blood flow (Doppler ultrasound) and calculated the vascular conductance (FVC) responses to brachial artery infusions of tyramine (which evokes endogenous noradrenaline release), phenylephrine (an ₁ agonist) and clonidine (an ₂ agonist) in 10 healthy men during rhythmic handgrip exercise (10-15 % of maximum) and during a control non-exercise vasodilator condition (intra-arterial adenosine). Steady-state FVC during exercise and adenosine was similar in all trials (range: 243-272 and 234-263 ml min^-1 (100 mmHg)^-1, respectively; P > 0.5). During exercise the percentage reductions in FVC in response to tyramine (-24 ± 7 vs. -55 ± 6 %), phenylephrine (-12 ± 8 vs. -37 ± 8 %) and clonidine (-17 ± 6 vs. -49 ± 4 %) were significantly less compared with adenosine (all P < 0.05). The magnitude of the blunted vasoconstrictor responses was similar for both receptor subtypes. These findings are in contrast to those from studies in animals demonstrating that ₂-adrenergic receptor-mediated vasoconstrictor responses are much more sensitive to contraction-induced inhibition than ₁-mediated responses. We conclude that vasoconstrictor responses mediated via both post-junctional ₁- and ₂-adrenergic receptors are blunted in contracting human skeletal muscles.

This article has been cited by other articles:

				B. S. Kirby, W. F. Voyles, R. E. Carlson, and F. A. Dinenno Graded sympatholytic effect of exogenous ATP on postjunctional {alpha}-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle J. Physiol., September 1, 2008; 586(17): 4305 - 4316. [Abstract] [Full Text] [PDF]

				D. W. Wray, S. K. Nishiyama, R. A. Harris, and R. S. Richardson Angiotensin II in the Elderly: Impact of Angiotensin II Type 1 Receptor Sensitivity on Peripheral Hemodynamics Hypertension, June 1, 2008; 51(6): 1611 - 1616. [Abstract] [Full Text] [PDF]

				S. Masuki, J. H. Eisenach, W. G. Schrage, C. P. Johnson, N. M. Dietz, B. W. Wilkins, P. Sandroni, P. A. Low, and M. J. Joyner Reduced stroke volume during exercise in postural tachycardia syndrome J Appl Physiol, October 1, 2007; 103(4): 1128 - 1135. [Abstract] [Full Text] [PDF]

				R. Moradkhan, P. McQuillan, C. Hogeman, A. Leuenberger, L. Linton-Frazier, and U. A. Leuenberger Metabolic forearm vasodilation is enhanced following Bier block with phentolamine Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2289 - H2295. [Abstract] [Full Text] [PDF]

				D. W. Wray, S. K. Nishiyama, A. J. Donato, M. Sander, P. D. Wagner, and R. S. Richardson Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2550 - H2556. [Abstract] [Full Text] [PDF]

				B. Saltin Exercise hyperaemia: magnitude and aspects on regulation in humans J. Physiol., September 15, 2007; 583(3): 819 - 823. [Abstract] [Full Text] [PDF]

				R. M. Brothers, M. L. Haslund, D. W. Wray, P. B. Raven, and M. Sander Exercise-induced inhibition of angiotensin II vasoconstriction in human thigh muscle J. Physiol., December 1, 2006; 577(2): 727 - 737. [Abstract] [Full Text] [PDF]

				B. W. Wilkins, W. G. Schrage, Z. Liu, K. C. Hancock, and M. J. Joyner Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle J Appl Physiol, November 1, 2006; 101(5): 1343 - 1350. [Abstract] [Full Text] [PDF]

				R. H. Rosa Jr., T. W. Hein, Z. Yuan, W. Xu, M. I. Pechal, R. L. Geraets, J. M. Newman, and L. Kuo Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H231 - H238. [Abstract] [Full Text] [PDF]

				D. S. DeLorey, J. J. Hamann, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter {alpha}-Adrenergic receptor-mediated restraint of skeletal muscle blood flow during prolonged exercise J Appl Physiol, May 1, 2006; 100(5): 1563 - 1568. [Abstract] [Full Text] [PDF]

				W. G. Schrage, N. M. Dietz, and M. J. Joyner Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise J Appl Physiol, May 1, 2006; 100(5): 1506 - 1512. [Abstract] [Full Text] [PDF]

				M. E. Tschakovsky, K. Shoemaker, and M. A. Babcock Comment on Point:Counterpoint "The muscle metaboreflex does/does not restore blood flow to contracting muscles" J Appl Physiol, March 1, 2006; 100(3): 1084 - 1085. [Full Text] [PDF]

				J. B. Buckwalter, J. J. Hamann, and P. S. Clifford Neuropeptide Y1 receptor vasoconstriction in exercising canine skeletal muscles J Appl Physiol, December 1, 2005; 99(6): 2115 - 2120. [Abstract] [Full Text] [PDF]

				W. G. Schrage, B. W. Wilkins, V. L. Dean, J. P. Scott, N. K. Henry, M. E. Wylam, and M. J. Joyner Exercise hyperemia and vasoconstrictor responses in humans with cystic fibrosis J Appl Physiol, November 1, 2005; 99(5): 1866 - 1871. [Abstract] [Full Text] [PDF]

				F. A Dinenno, S. Masuki, and M. J Joyner Impaired modulation of sympathetic {alpha}-adrenergic vasoconstriction in contracting forearm muscle of ageing men J. Physiol., August 15, 2005; 567(1): 311 - 321. [Abstract] [Full Text] [PDF]

				S. Masuki, F. A. Dinenno, M. J. Joyner, and J. H. Eisenach Selective {alpha}2-adrenergic properties of dexmedetomidine over clonidine in the human forearm J Appl Physiol, August 1, 2005; 99(2): 587 - 592. [Abstract] [Full Text] [PDF]

				S. C. Newcomer, U. A. Leuenberger, C. S. Hogeman, and D. N. Proctor Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H308 - H315. [Abstract] [Full Text] [PDF]

				D. G Lambert and G. D Thomas {alpha}-Adrenoceptor constrictor responses and their modulation in slow-twitch and fast-twitch mouse skeletal muscle J. Physiol., March 15, 2005; 563(3): 821 - 829. [Abstract] [Full Text] [PDF]

				S. Mannion, I. Hayes, F. Loughnane, D. B. Murphy, and G. D. Shorten Intravenous but Not Perineural Clonidine Prolongs Postoperative Analgesia After Psoas Compartment Block with 0.5% Levobupivacaine for Hip Fracture Surgery Anesth. Analg., March 1, 2005; 100(3): 873 - 878. [Abstract] [Full Text] [PDF]

				F. A. Dinenno and M. J. Joyner Combined NO and PG inhibition augments {alpha}-adrenergic vasoconstriction in contracting human skeletal muscle Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2576 - H2584. [Abstract] [Full Text] [PDF]

				D. M. Keller, P. J Fadel, S. Ogoh, R. M. Brothers, M. Hawkins, A. Olivencia-Yurvati, and P. B Raven Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans J. Physiol., November 15, 2004; 561(1): 283 - 293. [Abstract] [Full Text] [PDF]

				W. G. Schrage, J. H. Eisenach, F. A. Dinenno, S. K. Roberts, C. P. Johnson, P. Sandroni, P. A. Low, and M. J. Joyner Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure J Appl Physiol, November 1, 2004; 97(5): 1978 - 1984. [Abstract] [Full Text] [PDF]

				C. J Weisbrod, L. F Arnolda, D. J McKitrick, G. O'Driscoll, K. Potter, and D. J Green Vasomotor responses to decreased venous return: effects of cardiac deafferentation in humans J. Physiol., November 1, 2004; 560(3): 919 - 927. [Abstract] [Full Text] [PDF]

				D. W. Wray, P. J. Fadel, D. M. Keller, S. Ogoh, M. Sander, P. B. Raven, and M. L. Smith Dynamic carotid baroreflex control of the peripheral circulation during exercise in humans J. Physiol., September 1, 2004; 559(2): 675 - 684. [Abstract] [Full Text] [PDF]

				G. D. Thomas and S. S. Segal Neural control of muscle blood flow during exercise J Appl Physiol, August 1, 2004; 97(2): 731 - 738. [Abstract] [Full Text] [PDF]

				J. C. Frisbee Enhanced arteriolar {alpha}-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats J Appl Physiol, August 1, 2004; 97(2): 764 - 772. [Abstract] [Full Text] [PDF]

				C. J. Weisbrod, P. R. Eastwood, G. O'Driscoll, J. H. Walsh, M. Best, J. R. Halliwill, and D. J. Green Vasomotor Responses to Hypoxia in Type 2 Diabetes Diabetes, August 1, 2004; 53(8): 2073 - 2078. [Abstract] [Full Text] [PDF]

				J. B. Buckwalter, J. J. Hamann, H. A. Kluess, and P. S. Clifford Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y? Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H144 - H149. [Abstract] [Full Text] [PDF]

				J. B. Rosenmeier, J. Hansen, and J. Gonzalez-Alonso Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle J. Physiol., July 1, 2004; 558(1): 351 - 365. [Abstract] [Full Text] [PDF]

				W. G. Schrage, M. J. Joyner, and F. A. Dinenno Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans J. Physiol., June 1, 2004; 557(2): 599 - 611. [Abstract] [Full Text] [PDF]

				S. C. Newcomer, U. A. Leuenberger, C. S. Hogeman, B. D. Handly, and D. N. Proctor Different vasodilator responses of human arms and legs J. Physiol., May 1, 2004; 556(3): 1001 - 1011. [Abstract] [Full Text] [PDF]

				D. W. Wray, P. J. Fadel, M. L. Smith, P. Raven, and M. Sander Inhibition of {alpha}-adrenergic vasoconstriction in exercising human thigh muscles J. Physiol., March 1, 2004; 555(2): 545 - 563. [Abstract] [Full Text] [PDF]

				J. B. Rosenmeier, S. J. Fritzlar, F. A. Dinenno, and M. J. Joyner Exogenous NO administration and {alpha}-adrenergic vasoconstriction in human limbs J Appl Physiol, December 1, 2003; 95(6): 2370 - 2374. [Abstract] [Full Text]