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This Article Full Text Full Text (PDF) Original Classic Paper All Versions of this Article: 548/2/336    most recent 2003.040394v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Roddie, I. C. Search for Related Content PubMed PubMed Citation Articles by Roddie, I. C. Related Collections Classical Perspectives

Sympathetic vasodilatation in human skin

Email: icroddie@mercuryin.es

In the decades preceding and following the Second World War, knowledge about the human peripheral circulation increased rapidly. A number of factors contributed. One was the increasing interest in the field and the analytical techniques used initially by Sir Thomas Lewis at the Department of Medicine, University College London, and spread by some of his colleagues, G. W. Pickering, R. T. Grant and R. S. B. Pearson. Another was the increased use of venous occlusion plethysmography for non-invasive measurements of blood flow in human limbs (Lewis & Grant, 1925; Grant & Pearson, 1938; Barcroft & Edholm, 1943; Greenfield, 1954). Subjects suffered little discomfort with this technique so it was relatively easy to recruit students and colleagues as volunteers for experiments. Before the advent of 'Research Ethical Committees' in the 1960s, there were fewer constraints on working with human subjects. Experimenters, most of whom had medical qualifications, conformed to their own (usually high) ethical standards. They were familiar with clinical procedures and the risks involved but controversy did arise from time to time (Roddie, 1977). Such work might be more difficult to do today because of ethical, medico-legal and bureaucratic considerations but it does continue despite these problems (Joyner & Halliwill, 2000). It is important that it does so if we are to understand how new molecular information might or might not operate in whole humans.

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