HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 548/2/411    most recent 2002.037127v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martina, M. Articles by Bergeron, R. Search for Related Content PubMed PubMed Citation Articles by Martina, M. Articles by Bergeron, R.

D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons

Marzia Martina, Nicholas V. Krasteniakov and Richard Bergeron

The organization of the neuronal hippocampal network depends on the tightly regulated interaction between pyramidal cells (PCs) and interneurons (Ints). NMDA receptor (NMDAR) activation requires the binding of glutamate and co-activation of the 'glycine site'. It has been reported that D-serine is a more potent endogenous agonist than glycine for that site. While many studies have focused on NMDAR function in PCs, little is known regarding the modulation of NMDARs in Ints. We studied the modulatory effect of D-serine on NMDAR EPSCs in PCs and in stratum radiatum Ints using whole-cell patch-clamp recording in rat acute hippocampal slices. We found that D-serine enhances NMDAR function and differently modulates NMDAR currents in both cell types. The augmentation of NMDAR currents by D-serine was significantly larger in PCs compared with Ints. Moreover, we found differences in the kinetics of NMDAR currents in PCs and Ints. Our findings indicate that regulation of NMDAR through the 'glycine site' depends on the cell types. We speculate that the observed differences arise from assemblies of diverse NMDAR subunits. Overall, our data suggest that D-serine may be involved in regulation of the excitation-inhibition balance in the CA1 hippocampal region.

This article has been cited by other articles:

				K. L. Meur, M. Galante, M. C. Angulo, and E. Audinat Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus J. Physiol., April 15, 2007; 580(2): 373 - 383. [Abstract] [Full Text] [PDF]

				M. Martina, M.-E. B.-Turcotte, S. Halman, G. Tsai, M. Tiberi, J. T Coyle, and R. Bergeron Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice J. Physiol., March 15, 2005; 563(3): 777 - 793. [Abstract] [Full Text] [PDF]

				A. Bradaia, R. Schlichter, and J. Trouslard Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord J. Physiol., August 15, 2004; 559(1): 169 - 186. [Abstract] [Full Text] [PDF]

				G. Tsai, R. J. Ralph-Williams, M. Martina, R. Bergeron, J. Berger-Sweeney, K. S. Dunham, Z. Jiang, S. B. Caine, and J. T. Coyle Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype PNAS, June 1, 2004; 101(22): 8485 - 8490. [Abstract] [Full Text] [PDF]

				M. Martina, Y. Gorfinkel, S. Halman, J. A. Lowe, P. Periyalwar, C. J. Schmidt, and R. Bergeron Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels J. Physiol., June 1, 2004; 557(2): 489 - 500. [Abstract] [Full Text] [PDF]