J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Volume 548, Number 2, 485-492, April 15, 2003 DOI: 10.1113/jphysiol.2002.037952
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
548/2/485    most recent
2002.037952v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perrier, J.-F.
Right arrow Articles by Hounsgaard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perrier, J.-F.
Right arrow Articles by Hounsgaard, J.
J Physiol (2003), 548.2, pp. 485-492
© Copyright 2003 D 2003 The Physiological Society
DOI: 10.1113/jphysiol.2002.037952

5-HT1A receptors increase excitability of spinal motoneurons by inhibiting a TASK-1-like K+ current in the adult turtle

Jean-François Perrier, Aidas Alaburda and Jørn Hounsgaard

Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark

The modulatory effects of serotonin mediated by 5-HT1A receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. In current-clamp mode, activation of 5-HT1A receptors by 8-OH-DPAT led to depolarization and an increase in input resistance in most motoneurons but caused hyperpolarization and a decrease in input resistance in the remaining smaller fraction of cells. When slices were preincubated in medium containing the 5-HT1A receptor antagonist WAY-100635, 8-OH-DPAT had no effect. In voltage-clamp mode, with 1 mM CsCl in the bathing medium, 8-OH-DPAT consistently inhibited a leak current that was sensitive to extracellular acidification and anandamide, a TASK-1 channel blocker. In medium with a low pH, as in the presence of anandamide, 8-OH-DPAT had no effect. Our results show that activation of 5-HT1A receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a TASK-1 potassium channel leading to depolarization and increased input resistance.



This article has been cited by other articles:


Home page
 J. Physiol.Home page
J.-F. Perrier and F. Cotel
Serotonin differentially modulates the intrinsic properties of spinal motoneurons from the adult turtle
J. Physiol., March 1, 2008; 586(5): 1233 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. C. Button, J. M. Kalmar, K. Gardiner, T. Marqueste, H. Zhong, R. R. Roy, V. R. Edgerton, and P. F. Gardiner
Does elimination of afferent input modify the changes in rat motoneurone properties that occur following chronic spinal cord transection?
J. Physiol., January 15, 2008; 586(2): 529 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P.-Y. Deng, S. K. S. Poudel, L. Rojanathammanee, J. E. Porter, and S. Lei
Serotonin Inhibits Neuronal Excitability by Activating Two-Pore Domain K+ Channels in the Entorhinal Cortex
Mol. Pharmacol., July 1, 2007; 72(1): 208 - 218.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. P. Shapiro and R. H. Lee
Synaptic Amplification Versus Bistability in Motoneuron Dendritic Processing: A Top-Down Modeling Approach
J Neurophysiol, June 1, 2007; 97(6): 3948 - 3960.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Mathie
Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors
J. Physiol., January 15, 2007; 578(2): 377 - 385.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. A. Rybak, N. A. Shevtsova, M. Lafreniere-Roula, and D. A. McCrea
Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion
J. Physiol., December 1, 2006; 577(2): 617 - 639.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. Zhong, M. Diaz-Rios, and R. M. Harris-Warrick
Serotonin Modulates the Properties of Ascending Commissural Interneurons in the Neonatal Mouse Spinal Cord
J Neurophysiol, March 1, 2006; 95(3): 1545 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. P. Carlin, Y. Dai, and L. M. Jordan
Cholinergic and Serotonergic Excitation of Ascending Commissural Neurons in the Thoraco-Lumbar Spinal Cord of the Neonatal Mouse
J Neurophysiol, February 1, 2006; 95(2): 1278 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. V. Bui, M. Ter-Mikaelian, D. Bedrossian, and P. K. Rose
Computational Estimation of the Distribution of L-type Ca2+ Channels in Motoneurons Based on Variable Threshold of Activation of Persistent Inward Currents
J Neurophysiol, January 1, 2006; 95(1): 225 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-F. Perrier and R. Delgado-Lezama
Synaptic Release of Serotonin Induced by Stimulation of the Raphe Nucleus Promotes Plateau Potentials in Spinal Motoneurons of the Adult Turtle
J. Neurosci., August 31, 2005; 25(35): 7993 - 7999.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. J. Schwartz, T. Gerachshenko, and S. Alford
5-HT Prolongs Ventral Root Bursting Via Presynaptic Inhibition of Synaptic Activity During Fictive Locomotion in Lamprey
J Neurophysiol, February 1, 2005; 93(2): 980 - 988.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 The Physiological Society.