| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
There is some evidence, mainly from rodent studies, that any factor which alters the final total number of nephrons formed, during nephrogenesis, will result in hypertension in adult life. Sheep, programmed to become hypertensive by exposure to synthetic glucocorticoid (dexamethasone, 0.48 mg h-1, for 48 h) early in development (~27 days of gestation), were killed at 7 years of age, and had nephron counting performed by unbiased stereology. Mean arterial pressure was 83 ± 4 mmHg in the dexamethasone (DEX) group (n = 5), and 73 ± 5 in the control (CON; n = 7; P < 0.05). The total nephron number, in the right kidney (249 070 ± 14 331; n = 5) was significantly lower (P < 0.01) than that of controls (402 787 ± 30 458; n = 7). Mean glomerular volume was larger in the DEX than the CON group (P < 0.01), but there was no significant difference in the sclerosis index between the two groups. Low nephron number was associated with grossly enlarged and dilated proximal tubules and greater accumulation of collagen type I and type III in the tubular interstitium and periadventitia of the renal cortical vessels. These data suggest that the hypertensive programming effect of glucocorticoid treatment, early in kidney development, results, at least in part, from impaired nephrogenesis.
This article has been cited by other articles:
|
|
 |
|
  K. M. Moritz, R. R. Singh, M. E. Probyn, and K. M. Denton Developmental programming of a reduced nephron endowment: more than just a baby's birth weight Am J Physiol Renal Physiol, January 1, 2009; 296(1): F1 - F9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Brandon, A. C. Boyce, E. R. Lumbers, and K. J. Gibson Maternal renal dysfunction in sheep is associated with salt insensitivity in female offspring J. Physiol., January 1, 2009; 587(1): 261 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kantorowicz, N. K. Valego, LiJun Tang, J. P. Figueroa, M. C. Chappell, L. C. Carey, and J. C. Rose Plasma and Renal Renin Concentrations in Adult Sheep After Prenatal Betamethasone Exposure Reproductive Sciences, October 1, 2008; 15(8): 831 - 838. [Abstract] [PDF]
|
|
|
|
 |
|
 A. E. Michael and A. T. Papageorghiou Potential significance of physiological and pharmacological glucocorticoids in early pregnancy Hum. Reprod. Update, September 1, 2008; 14(5): 497 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. McNamara, B. Diouf, M. D. Hughson, R. N. Douglas-Denton, W. E. Hoy, and J. F. Bertram Renal pathology, glomerular number and volume in a West African urban community Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2576 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Gray, K. Kenna, J. F. Bertram, W. E. Hoy, E. B. Yan, A. D. Bocking, J. F. Brien, D. W. Walker, R. Harding, and K. M. Moritz Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R568 - R574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wyrwoll, P. J. Mark, and B. J. Waddell Developmental Programming of Renal Glucocorticoid Sensitivity and the Renin-Angiotensin System Hypertension, September 1, 2007; 50(3): 579 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singh, K. M. Moritz, J. F. Bertram, and L. A. Cullen-McEwen Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies Am J Physiol Renal Physiol, August 1, 2007; 293(2): F548 - F554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baserga, M. A. Hale, Z. M. Wang, X. Yu, C. W. Callaway, R. A. McKnight, and R. H. Lane Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1943 - R1955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singh, L. A. Cullen-McEwen, M. M. Kett, W.-M. Boon, J. Dowling, J. F. Bertram, and K. M. Moritz Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring J. Physiol., March 1, 2007; 579(2): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dagan, J. Gattineni, V. Cook, and M. Baum Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1230 - R1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Maduwegedera, M. M. Kett, R. L. Flower, G. W. Lambert, J. F. Bertram, E. M. Wintour, and K. M. Denton Sex differences in postnatal growth and renal development in offspring of rabbit mothers with chronic secondary hypertension Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R706 - R714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dickinson, D. W. Walker, E. M. Wintour, and K. Moritz Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R453 - R461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stubbe, K. Madsen, F. T. Nielsen, O. Skott, and B. L. Jensen Glucocorticoid impairs growth of kidney outer medulla and accelerates loop of Henle differentiation and urinary concentrating capacity in rat kidney development Am J Physiol Renal Physiol, October 1, 2006; 291(4): F812 - F822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Segar, R. D. Roghair, E. M. Segar, M. C. Bailey, T. D. Scholz, and F. S. Lamb Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R481 - R488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baserga, M. A. Hale, X. Ke, Z. M. Wang, X. Yu, C. W. Callaway, R. A. McKnight, and R. H. Lane Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R412 - R418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Massmann, J. Zhang, J. C. Rose, and J. P. Figueroa Acute and Long-Term Effects of Clinical Doses of Antenatal Glucocorticoids in the Developing Fetal Sheep Kidney Reproductive Sciences, April 1, 2006; 13(3): 174 - 180. [Abstract] [PDF]
|
|
|
|
|
|
K. Zandi-Nejad, V. A. Luyckx, and B. M. Brenner Adult Hypertension and Kidney Disease: The Role of Fetal Programming Hypertension, March 1, 2006; 47(3): 502 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Alexander Fetal programming of hypertension Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R1 - R10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Vehaskari and L. L. Woods Prenatal Programming of Hypertension: Lessons from Experimental Models J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2545 - 2556. [Full Text] [PDF]
|
|
|
|
|
|
H. Dickinson, D. W. Walker, L. Cullen-McEwen, E. M. Wintour, and K. Moritz The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth Am J Physiol Renal Physiol, August 1, 2005; 289(2): F273 - F279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Armitage, L. Lakasing, P. D. Taylor, A. A. Balachandran, R. I. Jensen, V. Dekou, N. Ashton, J. R. Nyengaard, and L. Poston Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy J. Physiol., May 15, 2005; 565(1): 171 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Gilbert, A. L. Lang, A. R. Grant, and M. J. Nijland Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age J. Physiol., May 15, 2005; 565(1): 137 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Moritz, A. Jefferies, E. M. Wintour, and M. Dodic Fetal renal and blood pressure responses to steroid infusion after early prenatal treatment with dexamethasone Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R62 - R66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tendron-Franzin, J.-B. Gouyon, J.-P. Guignard, S. Decramer, E. Justrabo, T. Gilbert, and D. Salomon Semama Long-Term Effects of In Utero Exposure to Cyclosporin A on Renal Function in the Rabbit J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2687 - 2693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Gopalakrishnan, D. S. Gardner, S. M. Rhind, M. T. Rae, C. E. Kyle, A. N. Brooks, R. M. Walker, M. M. Ramsay, D. H. Keisler, T. Stephenson, et al. Programming of adult cardiovascular function after early maternal undernutrition in sheep Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R12 - R20. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
