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J Physiol Volume 551, Number 1, 67-78, August 15, 2003 DOI: 10.1113/jphysiol.2003.042598
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J Physiol (2003), 551.1, pp. 67-78
© Copyright 2003 The Physiological Society
DOI: 10.1113/jphysiol.2003.042598

Ca2+ imaging of mouse neocortical interneurone dendrites: Contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics

Jesse H. Goldberg, Rafael Yuste and Gabor Tamas*

Department of Biological Sciences, Columbia University, New York, NY 10027, USA and *Department of Comparative Physiology, University of Szeged, Szeged, Hungary H-6726

In this second study, we have combined two-photon calcium imaging with whole-cell recording and anatomic reconstructions to directly characterize synaptically evoked calcium signals in three types of mouse V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), calretinin-positive irregular spikers (IS), and adapting cells (AD). We observed that subthreshold synaptic activation evoked calcium signals locally restricted to individual dendritic compartments. These signals were mediated by NMDA receptors (NMDARs) in AD and IS cells, whereas in FS cells, calcium-permeable AMPA receptors (CP-AMPARs) provided an additional and kinetically distinct influx. Furthermore, even a single, subthreshold synaptic activation evoked a larger dendritic calcium influx than backpropagating action potentials. Our results demonstrate that NMDARs dominate subthreshold calcium dynamics in interneurones and reveal the functional contribution of CP-AMPARs to a specific subclass of cortical interneurone. These data highlight different strategies in dendritic signal processing by distinct classes of interneurones.



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