| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Congestive heart failure (CHF) induces alterations in energy metabolism and mitochondrial function that span cardiac as well as skeletal muscles. Whether these defects originate from altered mitochondrial DNA copy number and/or mitochondrial gene transcription is not known at present, nor are the factors that control mitochondrial capacity in different muscle types completely understood. We used an experimental model of CHF induced by aortic banding in the rat and investigated mitochondrial respiration and enzyme activity of biochemical mitochondrial markers in cardiac, slow and fast skeletal muscles. We quantified mitochondrial DNA (mtDNA), expression of nuclear (COX IV) and mitochondrial (COX I) encoded cytochrome c oxidase subunits as well as nuclear factors involved in mitochondrial biogenesis and in the necessary coordinated interplay between nuclear and mitochondrial genomes in health and CHF. CHF induced a decrease in oxidative capacity and mitochondrial enzyme activities with a parallel decrease in the mRNA level of COX I and IV, but no change in mtDNA content. The expression of the peroxisome proliferator activated receptor gamma co-activator 1(PGC-1
This article has been cited by other articles:
|
|
 |
|
  F. Wu, E. Y. Zhang, J. Zhang, R. J. Bache, and D. A. Beard Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts J. Physiol., September 1, 2008; 586(17): 4193 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chicco, G. C. Sparagna, S. A. McCune, C. A. Johnson, R. C. Murphy, D. A. Bolden, M. L. Rees, R. T. Gardner, and R. L. Moore Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets Hypertension, September 1, 2008; 52(3): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Rennison, T. A. McElfresh, I. C. Okere, H. V. Patel, A. B. Foster, K. K. Patel, M. S. Stoll, P. E. Minkler, H. Fujioka, B. D. Hoit, et al. Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure Cardiovasc Res, July 15, 2008; 79(2): 331 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ventura-Clapier, A. Garnier, and V. Veksler Transcriptional control of mitochondrial biogenesis: the central role of PGC-1{alpha} Cardiovasc Res, July 15, 2008; 79(2): 208 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Lehman, S. Boudina, N. H. Banke, N. Sambandam, X. Han, D. M. Young, T. C. Leone, R. W. Gross, E. D. Lewandowski, E. D. Abel, et al. The transcriptional coactivator PGC-1{alpha} is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H185 - H196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Doenst, H. Bugger, M. Schwarzer, G. Faerber, M. A. Borger, and F. W. Mohr Three good reasons for heart surgeons to understand cardiac metabolism Eur. J. Cardiothorac. Surg., May 1, 2008; 33(5): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Rasbach and R. G. Schnellmann Isoflavones Promote Mitochondrial Biogenesis J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 536 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Arany, B. K. Wagner, Y. Ma, J. Chinsomboon, D. Laznik, and B. M. Spiegelman Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1{alpha} and oxidative phosphorylation PNAS, March 25, 2008; 105(12): 4721 - 4726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Remels, H. R. Gosker, P. Schrauwen, R. C. Langen, and A. M. Schols Peroxisome proliferator-activated receptors: a therapeutic target in COPD? Eur. Respir. J., March 1, 2008; 31(3): 502 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-a Kim, Y. Wei, and J. R. Sowers Role of Mitochondrial Dysfunction in Insulin Resistance Circ. Res., February 29, 2008; 102(4): 401 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bhashyam, P. Parikh, H. Bolukoglu, A. H. Shannon, J. H. Porter, Y.-T. Shen, and R. P. Shannon Aging is associated with myocardial insulin resistance and mitochondrial dysfunction Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3063 - H3071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, M. A. Hoydal, P. M. Haram, A. Garnier, D. Fortin, R. Ventura-Clapier, and O. Ellingsen Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan Cardiovasc Res, October 1, 2007; 76(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Sathyapala, P. Kemp, and M. I. Polkey Decreased muscle PPAR concentrations: a mechanism underlying skeletal muscle abnormalities in COPD? Eur. Respir. J., August 1, 2007; 30(2): 191 - 193. [Full Text] [PDF]
|
|
|
|
|
|
A. H. Remels, P. Schrauwen, R. Broekhuizen, J. Willems, S. Kersten, H. R. Gosker, and A. M. Schols Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD Eur. Respir. J., August 1, 2007; 30(2): 245 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ashrafian, M. P. Frenneaux, and L. H. Opie Metabolic Mechanisms in Heart Failure Circulation, July 24, 2007; 116(4): 434 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Sparagna, A. J. Chicco, R. C. Murphy, M. R. Bristow, C. A. Johnson, M. L. Rees, M. L. Maxey, S. A. McCune, and R. L. Moore Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure J. Lipid Res., July 1, 2007; 48(7): 1559 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Watson, J. E. B. Reusch, S. A. McCune, L. A. Leinwand, S. W. Luckey, J. P. Konhilas, D. A. Brown, A. J. Chicco, G. C. Sparagna, C. S. Long, et al. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H246 - H259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Finck and D. P. Kelly Peroxisome Proliferator-Activated Receptor {gamma} Coactivator-1 (PGC-1) Regulatory Cascade in Cardiac Physiology and Disease Circulation, May 15, 2007; 115(19): 2540 - 2548. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Neubauer The Failing Heart -- An Engine Out of Fuel N. Engl. J. Med., March 15, 2007; 356(11): 1140 - 1151. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Athea, B. Viollet, P. Mateo, D. Rousseau, M. Novotova, A. Garnier, S. Vaulont, J. R. Wilding, A. Grynberg, V. Veksler, et al. AMP-Activated Protein Kinase {alpha}2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function Diabetes, March 1, 2007; 56(3): 786 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Rennison, T. A. McElfresh, I. C. Okere, E. J. Vazquez, H. V. Patel, A. B. Foster, K. K. Patel, Q. Chen, B. D. Hoit, K.-Y. Tserng, et al. High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1498 - H1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Finck The PPAR regulatory system in cardiac physiology and disease Cardiovasc Res, January 15, 2007; 73(2): 269 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ventura-Clapier, B. Mettauer, and X. Bigard Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure Cardiovasc Res, January 1, 2007; 73(1): 10 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Javadov, D. M. Purdham, A. Zeidan, and M. Karmazyn NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1722 - H1730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zoll, L. Monassier, A. Garnier, B. N'Guessan, B. Mettauer, V. Veksler, F. Piquard, R. Ventura-Clapier, and B. Geny ACE inhibition prevents myocardial infarction-induced skeletal muscle mitochondrial dysfunction J Appl Physiol, August 1, 2006; 101(2): 385 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Arany, M. Novikov, S. Chin, Y. Ma, A. Rosenzweig, and B. M. Spiegelman Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-{gamma} coactivator 1{alpha} PNAS, June 27, 2006; 103(26): 10086 - 10091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Petermann, C. Mayer, J. Stypmann, M. L. Biniossek, D. J. Tobin, M. A. Engelen, T. Dandekar, T. Grune, L. Schild, C. Peters, et al. Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice FASEB J, June 1, 2006; 20(8): 1266 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Appleyard, G. W. Forsyth, L. M. Kiehlbauch, K. N. Sigfrid, H. L. J. Hanik, A. Quon, M. E. Loewen, and B. H. Grahn Differential Mitochondrial DNA and Gene Expression in Inherited Retinal Dysplasia in Miniature Schnauzer Dogs Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1810 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sugimoto, N. R. Qi, L. Kazdova, M. Pravenec, T. Ogihara, and T. W. Kurtz Telmisartan But Not Valsartan Increases Caloric Expenditure and Protects Against Weight Gain and Hepatic Steatosis Hypertension, May 1, 2006; 47(5): 1003 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ojaimi, W. Li, S. Kinugawa, H. Post, A. Csiszar, P. Pacher, G. Kaley, and T. H. Hintze Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1399 - H1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Supinski and L. A. Callahan Diaphragmatic free radical generation increases in an animal model of heart failure J Appl Physiol, September 1, 2005; 99(3): 1078 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ikeuchi, H. Matsusaka, D. Kang, S. Matsushima, T. Ide, T. Kubota, T. Fujiwara, N. Hamasaki, A. Takeshita, K. Sunagawa, et al. Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction Circulation, August 2, 2005; 112(5): 683 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk Myocardial Substrate Metabolism in the Normal and Failing Heart Physiol Rev, July 1, 2005; 85(3): 1093 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. J. Buermans, E. M. Redout, A. E. Schiel, R. J. P. Musters, M. Zuidwijk, P. P. Eijk, C. van Hardeveld, S. Kasanmoentalib, F. C. Visser, B. Ylstra, et al. Microarray analysis reveals pivotal divergent mRNA expression profiles early in the development of either compensated ventricular hypertrophy or heart failure Physiol Genomics, May 11, 2005; 21(3): 314 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Garnier, D. Fortin, J. Zoll, B. N'Guessan, B. Mettauer, E. Lampert, V. Veksler, and R. Ventura-Clapier Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle FASEB J, January 1, 2005; 19(1): 43 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goffart, J.-C. von Kleist-Retzow, and R. J. Wiesner Regulation of mitochondrial proliferation in the heart: power-plant failure contributes to cardiac failure in hypertrophy Cardiovasc Res, November 1, 2004; 64(2): 198 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sano and M. D. Schneider Cyclin-Dependent Kinase-9: An RNAPII Kinase at the Nexus of Cardiac Growth and Death Cascades Circ. Res., October 29, 2004; 95(9): 867 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Ingwall and R. G. Weiss Is the Failing Heart Energy Starved?: On Using Chemical Energy to Support Cardiac Function Circ. Res., July 23, 2004; 95(2): 135 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ventura-Clapier, A. Garnier, and V. Veksler Energy metabolism in heart failure J. Physiol., February 15, 2004; 555(1): 1 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Czubryt and E. N. Olson Balancing Contractility and Energy Production: The Role of Myocyte Enhancer Factor 2 (MEF2) in Cardiac Hypertrophy Recent Prog. Horm. Res., January 1, 2004; 59(1): 105 - 124. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
