| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In many neurons, trains of action potentials show frequency-dependent broadening. This broadening results from the voltage-dependent inactivation of K+ currents that contribute to action potential repolarisation. In different neuronal cell types these K+ currents have been shown to be either slowly inactivating delayed rectifier type currents or rapidly inactivating A-type voltage-gated K+ currents. Recent findings show that inactivation of a Ca2+-dependent K+ current, mediated by large conductance BK-type channels, also contributes to spike broadening. Here, using whole-cell recordings in acute slices, we examine spike broadening in lateral amygdala projection neurons. Spike broadening is frequency dependent and is reversed by brief hyperpolarisations. This broadening is reduced by blockade of voltage-gated Ca2+ channels and BK channels. In contrast, broadening is not blocked by high concentrations of 4-aminopyridine (4-AP) or-dendrotoxin. We conclude that while inactivation of BK-type Ca2+-activated K+ channels contributes to spike broadening in lateral amygdala neurons, inactivation of another as yet unidentified outward current also plays a role.
This article has been cited by other articles:
|
|
 |
|
  Y. Fu and V. Neugebauer Differential Mechanisms of CRF1 and CRF2 Receptor Functions in the Amygdala in Pain-Related Synaptic Facilitation and Behavior J. Neurosci., April 9, 2008; 28(15): 3861 - 3876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Loane, P. A. Lima, and N. V. Marrion Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain J. Cell Sci., March 15, 2007; 120(6): 985 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Likhtik, J. G. Pelletier, A. T. Popescu, and D. Pare Identification of Basolateral Amygdala Projection Cells and Interneurons Using Extracellular Recordings J Neurophysiol, December 1, 2006; 96(6): 3257 - 3265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Oliver, A. M. Taberner, H. Thurm, M. Sausbier, C. Arntz, P. Ruth, B. Fakler, and M. C. Liberman The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J. Neurosci., June 7, 2006; 26(23): 6181 - 6189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Finnegan, S.-R. Chen, and H.-L. Pan {micro} Opioid Receptor Activation Inhibits GABAergic Inputs to Basolateral Amygdala Neurons Through Kv1.1/1.2 Channels J Neurophysiol, April 1, 2006; 95(4): 2032 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kim, D.-S. Wei, and D. A. Hoffman Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones J. Physiol., November 15, 2005; 569(1): 41 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Bahia, R. Suzuki, D. C. H. Benton, A. J. Jowett, M. X. Chen, Derek. J. Trezise, A. H. Dickenson, and G. W. J. Moss A Functional Role for Small-Conductance Calcium-Activated Potassium Channels in Sensory Pathways Including Nociceptive Processes J. Neurosci., April 6, 2005; 25(14): 3489 - 3498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ouyang and H. C. Hemmings Jr. Depression by Isoflurane of the Action Potential and Underlying Voltage-Gated Ion Currents in Isolated Rat Neurohypophysial Nerve Terminals J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 801 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-P. Sun, B. Yazejian, and A. D. Grinnell Electrophysiological properties of BK channels in Xenopus motor nerve terminals J. Physiol., May 15, 2004; 557(1): 207 - 228. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
