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This Article Full Text Full Text (PDF) All Versions of this Article: 553/1/1    most recent jphysiol.2003.054197v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rennie, M. J. Articles by Wackerhage, H. Search for Related Content PubMed PubMed Citation Articles by Rennie, M. J. Articles by Wackerhage, H. Related Collections Perspectives

Connecting the dots for mechanochemical transduction in muscle

Michael J. Rennie and Henning Wackerhage

One of the most impressive adaptive physiological responses is that of muscle to high intensity exercise, as espoused by power athletes and body builders, which results in increases in muscle mass. Athletics and vanity aside, there are many reasons for wishing to know more about the mechanisms underlying this hypertrophy, not least being the possibility of pharmacologically enhancing it in sarcopenia. The work of Bolster and colleagues in this issue of The Journal of Physiology brings us nearer to a complete understanding of the relevant subcellular events occurring in response to resistance exercise by providing a time course of activities of signalling proteins involved in regulating the translational phase of muscle protein synthesis.

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